Tamoxifen stimulates human papillomavirus type 16 gene expression and cell proliferation in a cervical cancer cell line

The widely adopted use of tamoxifen as a chemotherapeutic agent is primarily based on its inhibition of cancer cell growth. However, we report that tamoxifen at low concentrations (10(-9) and 10(-11) M) causes stimulation of cell proliferation in a cervical cancer cell line, SFR. The facts that SFR...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1992-12, Vol.52 (24), p.6848-6852
Hauptverfasser:	JIN-YUN HWANG, BI-YU LIN, FEN-MEI TANG, YU, W. C. Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Division - drug effects Drug toxicity and drugs side effects treatment Female Gene Expression - drug effects Humans Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Oncogene Proteins, Viral - biosynthesis Papillomaviridae - genetics Papillomavirus E7 Proteins Pharmacology. Drug treatments Receptors, Drug Receptors, Estrogen - analysis RNA, Messenger - analysis Tamoxifen - pharmacology Tumor Cells, Cultured Uterine Cervical Neoplasms - microbiology Uterine Cervical Neoplasms - pathology
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