Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat
The effects of moderate hypothermia on blood-brain barrier (BBB) permeability and the acute hypertensive response after moderate traumatic brain injury (TBI) in rats were examined. TBI produced increased vascular permeability to endogenous serum albumin (IgG) in normothermic rats (37.5 degrees C) th...
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Veröffentlicht in: | Acta neuropathologica 1992-10, Vol.84 (5), p.495-500 |
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description | The effects of moderate hypothermia on blood-brain barrier (BBB) permeability and the acute hypertensive response after moderate traumatic brain injury (TBI) in rats were examined. TBI produced increased vascular permeability to endogenous serum albumin (IgG) in normothermic rats (37.5 degrees C) throughout the dorsal cortical gray and white matter as well as in the underlying hippocampi as visualized by immunocytochemical techniques. Vascular permeability was greatly reduced in hypothermic rats cooled to 30 degrees C (brain temperature) prior to injury. In hypothermic rats, albumin immunoreactivity was confined to the gray-white interface between cortex and hippocampi with no involvement of the overlying cortices and greatly reduced involvement of the underlying hippocampi. The acute hypertensive response in normothermic rats peaked at 10 s after TBI (187.3 mm Hg) and returned to baseline within 50 s. In contrast, the peak acute hypertensive response was significantly (P < 0.05) reduced in hypothermic rats (154.8 mm Hg, 10 s after TBI) and returned to baseline at 30 s after injury. These results demonstrate that moderate hypothermia greatly reduces endogenous vascular protein-tracer passage into and perhaps through the brain. This reduction may, in part, be related to hypothermia-induced modulation of the systemic blood pressure response to TBI. |
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Y ; LYETH, B. G ; KAPASI, M. Z ; JENKINS, L. W ; POVLISHOCK, J. T</creator><creatorcontrib>JIANG, J. Y ; LYETH, B. G ; KAPASI, M. Z ; JENKINS, L. W ; POVLISHOCK, J. T</creatorcontrib><description>The effects of moderate hypothermia on blood-brain barrier (BBB) permeability and the acute hypertensive response after moderate traumatic brain injury (TBI) in rats were examined. TBI produced increased vascular permeability to endogenous serum albumin (IgG) in normothermic rats (37.5 degrees C) throughout the dorsal cortical gray and white matter as well as in the underlying hippocampi as visualized by immunocytochemical techniques. Vascular permeability was greatly reduced in hypothermic rats cooled to 30 degrees C (brain temperature) prior to injury. In hypothermic rats, albumin immunoreactivity was confined to the gray-white interface between cortex and hippocampi with no involvement of the overlying cortices and greatly reduced involvement of the underlying hippocampi. The acute hypertensive response in normothermic rats peaked at 10 s after TBI (187.3 mm Hg) and returned to baseline within 50 s. In contrast, the peak acute hypertensive response was significantly (P < 0.05) reduced in hypothermic rats (154.8 mm Hg, 10 s after TBI) and returned to baseline at 30 s after injury. These results demonstrate that moderate hypothermia greatly reduces endogenous vascular protein-tracer passage into and perhaps through the brain. This reduction may, in part, be related to hypothermia-induced modulation of the systemic blood pressure response to TBI.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/BF00304468</identifier><identifier>PMID: 1462764</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Blood Gas Analysis ; Blood Pressure - physiology ; Blood-Brain Barrier - physiology ; Body Temperature ; Brain Injuries - blood ; Brain Injuries - pathology ; Brain Injuries - physiopathology ; Capillary Permeability - physiology ; Cerebrovascular Circulation - physiology ; Hypothermia, Induced ; Medical sciences ; Nervous system involvement in other diseases. 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Y</creatorcontrib><creatorcontrib>LYETH, B. G</creatorcontrib><creatorcontrib>KAPASI, M. Z</creatorcontrib><creatorcontrib>JENKINS, L. W</creatorcontrib><creatorcontrib>POVLISHOCK, J. T</creatorcontrib><title>Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>The effects of moderate hypothermia on blood-brain barrier (BBB) permeability and the acute hypertensive response after moderate traumatic brain injury (TBI) in rats were examined. TBI produced increased vascular permeability to endogenous serum albumin (IgG) in normothermic rats (37.5 degrees C) throughout the dorsal cortical gray and white matter as well as in the underlying hippocampi as visualized by immunocytochemical techniques. Vascular permeability was greatly reduced in hypothermic rats cooled to 30 degrees C (brain temperature) prior to injury. In hypothermic rats, albumin immunoreactivity was confined to the gray-white interface between cortex and hippocampi with no involvement of the overlying cortices and greatly reduced involvement of the underlying hippocampi. The acute hypertensive response in normothermic rats peaked at 10 s after TBI (187.3 mm Hg) and returned to baseline within 50 s. In contrast, the peak acute hypertensive response was significantly (P < 0.05) reduced in hypothermic rats (154.8 mm Hg, 10 s after TBI) and returned to baseline at 30 s after injury. These results demonstrate that moderate hypothermia greatly reduces endogenous vascular protein-tracer passage into and perhaps through the brain. This reduction may, in part, be related to hypothermia-induced modulation of the systemic blood pressure response to TBI.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Gas Analysis</subject><subject>Blood Pressure - physiology</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Body Temperature</subject><subject>Brain Injuries - blood</subject><subject>Brain Injuries - pathology</subject><subject>Brain Injuries - physiopathology</subject><subject>Capillary Permeability - physiology</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Hypothermia, Induced</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. 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Miscellaneous</topic><topic>Neurology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JIANG, J. Y</creatorcontrib><creatorcontrib>LYETH, B. G</creatorcontrib><creatorcontrib>KAPASI, M. Z</creatorcontrib><creatorcontrib>JENKINS, L. W</creatorcontrib><creatorcontrib>POVLISHOCK, J. T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JIANG, J. Y</au><au>LYETH, B. G</au><au>KAPASI, M. Z</au><au>JENKINS, L. W</au><au>POVLISHOCK, J. T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1992-10-01</date><risdate>1992</risdate><volume>84</volume><issue>5</issue><spage>495</spage><epage>500</epage><pages>495-500</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>The effects of moderate hypothermia on blood-brain barrier (BBB) permeability and the acute hypertensive response after moderate traumatic brain injury (TBI) in rats were examined. TBI produced increased vascular permeability to endogenous serum albumin (IgG) in normothermic rats (37.5 degrees C) throughout the dorsal cortical gray and white matter as well as in the underlying hippocampi as visualized by immunocytochemical techniques. Vascular permeability was greatly reduced in hypothermic rats cooled to 30 degrees C (brain temperature) prior to injury. In hypothermic rats, albumin immunoreactivity was confined to the gray-white interface between cortex and hippocampi with no involvement of the overlying cortices and greatly reduced involvement of the underlying hippocampi. The acute hypertensive response in normothermic rats peaked at 10 s after TBI (187.3 mm Hg) and returned to baseline within 50 s. In contrast, the peak acute hypertensive response was significantly (P < 0.05) reduced in hypothermic rats (154.8 mm Hg, 10 s after TBI) and returned to baseline at 30 s after injury. These results demonstrate that moderate hypothermia greatly reduces endogenous vascular protein-tracer passage into and perhaps through the brain. This reduction may, in part, be related to hypothermia-induced modulation of the systemic blood pressure response to TBI.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>1462764</pmid><doi>10.1007/BF00304468</doi><tpages>6</tpages></addata></record> |
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subjects | Animals Biological and medical sciences Blood Gas Analysis Blood Pressure - physiology Blood-Brain Barrier - physiology Body Temperature Brain Injuries - blood Brain Injuries - pathology Brain Injuries - physiopathology Capillary Permeability - physiology Cerebrovascular Circulation - physiology Hypothermia, Induced Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Rats |
title | Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat |
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