Suppression of Experimental Autoimmune Uveoretinitis by Inducing Differentiation of Regulatory T Cells via Activation of Aryl Hydrocarbon Receptor

Purpose. Aryl hydrocarbon receptor (AHR) has been identified as a regulator of CD25(+)CD4(+) regulatory T-cell (T(reg)) and Th17 cell differentiation in mice, and activation of AHR by its ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces functional T(reg) cells. In this study, the authors ex...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2010-04, Vol.51 (4), p.2109-2117
Hauptverfasser:	Zhang, Lina, Ma, Juan, Takeuchi, Masaru, Usui, Yoshihiko, Hattori, Takaaki, Okunuki, Yoko, Yamakawa, Naoyuki, Kezuka, Takeshi, Kuroda, Masahiko, Goto, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune Diseases - immunology Autoimmune Diseases - prevention & control Cell Differentiation - drug effects Cytokines - metabolism Eye Proteins Female Flow Cytometry Forkhead Transcription Factors - metabolism Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Polychlorinated Dibenzodioxins - pharmacology Receptors, Aryl Hydrocarbon - metabolism Retinitis - immunology Retinitis - prevention & control Retinol-Binding Proteins T-Lymphocytes - immunology T-Lymphocytes, Regulatory - immunology Uveitis - immunology Uveitis - prevention & control
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