Plasma B-Type Natriuretic Peptide Level and Cardiovascular Events in Chronic Kidney Disease in a Community-Based Population
Background: Plasma B-type natriuretic peptide (BNP) levels are confounded by renal dysfunction, so this study examined whether plasma BNP might be a reliable biomarker of the onset of cardiovascular (CV) events in a population-based cohort with impaired renal function. Methods and Results: Baseline...
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| Veröffentlicht in: | Circulation Journal 2010, Vol.74(4), pp.792-797 |
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| creator | Sakuma, Masafumi Nakamura, Motoyuki Tanaka, Fumitaka Onoda, Toshiyuki Itai, Kazuyoshi Tanno, Kozo Ohsawa, Masaki Sakata, Kiyomi Yoshida, Yuki Kawamura, Kazuko Makita, Shinji Okayama, Akira |
| description | Background: Plasma B-type natriuretic peptide (BNP) levels are confounded by renal dysfunction, so this study examined whether plasma BNP might be a reliable biomarker of the onset of cardiovascular (CV) events in a population-based cohort with impaired renal function. Methods and Results: Baseline data, including plasma BNP, serum creatinine, and urinary protein levels, were determined in participants from a community-based population. Estimated glomerular filtration rate (eGFR) was calculated, and chronic kidney disease (CKD) was defined as either: eGFR |
| doi_str_mv | 10.1253/circj.CJ-09-0834 |
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Methods and Results: Baseline data, including plasma BNP, serum creatinine, and urinary protein levels, were determined in participants from a community-based population. Estimated glomerular filtration rate (eGFR) was calculated, and chronic kidney disease (CKD) was defined as either: eGFR <60 ml·min-1·1.73 m-2 and/or proteinuria (CKD definition-1) or GFR <60 ml·min-1·1.73 m-2 (CKD definition-2). The CV endpoint was surveyed prospectively. The cohorts were followed for 5,275 person-years for CKD definition-1, and for 4,350 person-years for CKD definition-2. The CV event-free survival rate in the highest BNP quartile in either CKD definition was the lowest among the quartile groups (P<0.001). In multivariate Cox regression models adjusted by traditional CV risk factors and atrial fibrillation, relative risk (RR) for CV events was significantly higher in the highest BNP quartile compared with the lowest BNP quartile (CKD definition-1, RR 3.51, P<0.01: CKD definition-2, RR 4.67, both P<0.01). Conclusions: Plasma BNP level provides strong predictive information about the future onset of CV events in CKD subjects selected from the general population. (Circ J 2010; 74: 792-797)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-09-0834</identifier><identifier>PMID: 20160392</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Biomarkers - blood ; Cardiovascular Diseases - epidemiology ; Chronic Disease ; Cohort Studies ; Creatinine - blood ; Female ; General population ; Glomerular Filtration Rate - physiology ; Heart failure ; Humans ; Kidney Diseases - blood ; Kidney Diseases - physiopathology ; Male ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Prospective Studies ; Renal failure ; Risk Factors ; Stroke</subject><ispartof>Circulation Journal, 2010, Vol.74(4), pp.792-797</ispartof><rights>2010 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-3c240f3d487dd119137f5e46a839b4a623cd23dcbcf5f2b3b7ff85584f09f23a3</citedby><cites>FETCH-LOGICAL-c594t-3c240f3d487dd119137f5e46a839b4a623cd23dcbcf5f2b3b7ff85584f09f23a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20160392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakuma, Masafumi</creatorcontrib><creatorcontrib>Nakamura, Motoyuki</creatorcontrib><creatorcontrib>Tanaka, Fumitaka</creatorcontrib><creatorcontrib>Onoda, Toshiyuki</creatorcontrib><creatorcontrib>Itai, Kazuyoshi</creatorcontrib><creatorcontrib>Tanno, Kozo</creatorcontrib><creatorcontrib>Ohsawa, Masaki</creatorcontrib><creatorcontrib>Sakata, Kiyomi</creatorcontrib><creatorcontrib>Yoshida, Yuki</creatorcontrib><creatorcontrib>Kawamura, Kazuko</creatorcontrib><creatorcontrib>Makita, Shinji</creatorcontrib><creatorcontrib>Okayama, Akira</creatorcontrib><title>Plasma B-Type Natriuretic Peptide Level and Cardiovascular Events in Chronic Kidney Disease in a Community-Based Population</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background: Plasma B-type natriuretic peptide (BNP) levels are confounded by renal dysfunction, so this study examined whether plasma BNP might be a reliable biomarker of the onset of cardiovascular (CV) events in a population-based cohort with impaired renal function. Methods and Results: Baseline data, including plasma BNP, serum creatinine, and urinary protein levels, were determined in participants from a community-based population. Estimated glomerular filtration rate (eGFR) was calculated, and chronic kidney disease (CKD) was defined as either: eGFR <60 ml·min-1·1.73 m-2 and/or proteinuria (CKD definition-1) or GFR <60 ml·min-1·1.73 m-2 (CKD definition-2). The CV endpoint was surveyed prospectively. The cohorts were followed for 5,275 person-years for CKD definition-1, and for 4,350 person-years for CKD definition-2. The CV event-free survival rate in the highest BNP quartile in either CKD definition was the lowest among the quartile groups (P<0.001). In multivariate Cox regression models adjusted by traditional CV risk factors and atrial fibrillation, relative risk (RR) for CV events was significantly higher in the highest BNP quartile compared with the lowest BNP quartile (CKD definition-1, RR 3.51, P<0.01: CKD definition-2, RR 4.67, both P<0.01). Conclusions: Plasma BNP level provides strong predictive information about the future onset of CV events in CKD subjects selected from the general population. (Circ J 2010; 74: 792-797)</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Chronic Disease</subject><subject>Cohort Studies</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>General population</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Kidney Diseases - blood</subject><subject>Kidney Diseases - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Prospective Studies</subject><subject>Renal failure</subject><subject>Risk Factors</subject><subject>Stroke</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1vFDEQhi0EIiHQUyF3VA5e23u7LskmAcIJrgi1NWuPiU_7he096cSfZy93JM14NH7et3gIeV_wy0KU8pMN0W4vmzvGNeO1VC_IeSFVxVQt-MvHfcV0reQZeZPSlnOhealfkzPBixWXWpyTv5sOUg_0it3vJ6Q_IMcwR8zB0g1OOTika9xhR2FwtIHowriDZOcOIr3Z4ZATDQNtHuI4LJHvwQ24p9chISQ8_ABtxr6fh5D37Gq5OboZpyWdwzi8Ja88dAnfnd4L8uv25r75ytY_v3xrPq-ZLbXKTFqhuJdO1ZVzRaELWfkS1QpqqVsFKyGtE9LZ1vrSi1a2lfd1WdbKc-2FBHlBPh57pzj-mTFl04dksetgwHFOppKyXlSVaiH5kbRxTCmiN1MMPcS9Kbg5GDePxk1zZ7g2B-NL5MOpfG57dE-B_4oX4PYIbFOG3_gEQFwkd3hqrJRRh_Hc_Aw8QDQ4yH-kCpfx</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Sakuma, Masafumi</creator><creator>Nakamura, Motoyuki</creator><creator>Tanaka, Fumitaka</creator><creator>Onoda, Toshiyuki</creator><creator>Itai, Kazuyoshi</creator><creator>Tanno, Kozo</creator><creator>Ohsawa, Masaki</creator><creator>Sakata, Kiyomi</creator><creator>Yoshida, Yuki</creator><creator>Kawamura, Kazuko</creator><creator>Makita, Shinji</creator><creator>Okayama, Akira</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Plasma B-Type Natriuretic Peptide Level and Cardiovascular Events in Chronic Kidney Disease in a Community-Based Population</title><author>Sakuma, Masafumi ; Nakamura, Motoyuki ; Tanaka, Fumitaka ; Onoda, Toshiyuki ; Itai, Kazuyoshi ; Tanno, Kozo ; Ohsawa, Masaki ; Sakata, Kiyomi ; Yoshida, Yuki ; Kawamura, Kazuko ; Makita, Shinji ; Okayama, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-3c240f3d487dd119137f5e46a839b4a623cd23dcbcf5f2b3b7ff85584f09f23a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Chronic Disease</topic><topic>Cohort Studies</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>General population</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Kidney Diseases - blood</topic><topic>Kidney Diseases - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Prospective Studies</topic><topic>Renal failure</topic><topic>Risk Factors</topic><topic>Stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakuma, Masafumi</creatorcontrib><creatorcontrib>Nakamura, Motoyuki</creatorcontrib><creatorcontrib>Tanaka, Fumitaka</creatorcontrib><creatorcontrib>Onoda, Toshiyuki</creatorcontrib><creatorcontrib>Itai, Kazuyoshi</creatorcontrib><creatorcontrib>Tanno, Kozo</creatorcontrib><creatorcontrib>Ohsawa, Masaki</creatorcontrib><creatorcontrib>Sakata, Kiyomi</creatorcontrib><creatorcontrib>Yoshida, Yuki</creatorcontrib><creatorcontrib>Kawamura, Kazuko</creatorcontrib><creatorcontrib>Makita, Shinji</creatorcontrib><creatorcontrib>Okayama, Akira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakuma, Masafumi</au><au>Nakamura, Motoyuki</au><au>Tanaka, Fumitaka</au><au>Onoda, Toshiyuki</au><au>Itai, Kazuyoshi</au><au>Tanno, Kozo</au><au>Ohsawa, Masaki</au><au>Sakata, Kiyomi</au><au>Yoshida, Yuki</au><au>Kawamura, Kazuko</au><au>Makita, Shinji</au><au>Okayama, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma B-Type Natriuretic Peptide Level and Cardiovascular Events in Chronic Kidney Disease in a Community-Based Population</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2010</date><risdate>2010</risdate><volume>74</volume><issue>4</issue><spage>792</spage><epage>797</epage><pages>792-797</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background: Plasma B-type natriuretic peptide (BNP) levels are confounded by renal dysfunction, so this study examined whether plasma BNP might be a reliable biomarker of the onset of cardiovascular (CV) events in a population-based cohort with impaired renal function. Methods and Results: Baseline data, including plasma BNP, serum creatinine, and urinary protein levels, were determined in participants from a community-based population. Estimated glomerular filtration rate (eGFR) was calculated, and chronic kidney disease (CKD) was defined as either: eGFR <60 ml·min-1·1.73 m-2 and/or proteinuria (CKD definition-1) or GFR <60 ml·min-1·1.73 m-2 (CKD definition-2). The CV endpoint was surveyed prospectively. The cohorts were followed for 5,275 person-years for CKD definition-1, and for 4,350 person-years for CKD definition-2. The CV event-free survival rate in the highest BNP quartile in either CKD definition was the lowest among the quartile groups (P<0.001). In multivariate Cox regression models adjusted by traditional CV risk factors and atrial fibrillation, relative risk (RR) for CV events was significantly higher in the highest BNP quartile compared with the lowest BNP quartile (CKD definition-1, RR 3.51, P<0.01: CKD definition-2, RR 4.67, both P<0.01). Conclusions: Plasma BNP level provides strong predictive information about the future onset of CV events in CKD subjects selected from the general population. (Circ J 2010; 74: 792-797)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>20160392</pmid><doi>10.1253/circj.CJ-09-0834</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biomarkers - blood Cardiovascular Diseases - epidemiology Chronic Disease Cohort Studies Creatinine - blood Female General population Glomerular Filtration Rate - physiology Heart failure Humans Kidney Diseases - blood Kidney Diseases - physiopathology Male Middle Aged Natriuretic Peptide, Brain - blood Prospective Studies Renal failure Risk Factors Stroke |
| title | Plasma B-Type Natriuretic Peptide Level and Cardiovascular Events in Chronic Kidney Disease in a Community-Based Population |
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