Evidence for distinct alterations in the FGF axis in prostate cancer progression to an aggressive clinical phenotype

Multiple fibroblast growth factor (FGF) axis alterations are known to occur in prostate cancer. Here we simultaneously profiled key components of this axis to determine their relevance in disease progression. An optimized immunohistochemistry protocol was used in expression analysis of FGF2, FGF8, F...

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Veröffentlicht in:	The Journal of pathology 2010-03, Vol.220 (4), p.452-460
Hauptverfasser:	Murphy, Tania, Darby, Steve, Mathers, Marie E, Gnanapragasam, Vincent J
Format:	Artikel
Sprache:	eng
Schlagworte:	Benign Biological and medical sciences Biomarkers, Tumor - metabolism Bone Neoplasms - secondary Disease Progression FGF ligand FGF receptor Fibroblast growth factor Fibroblast growth factor 2 Fibroblast growth factor 8 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 4 Fibroblast growth factor receptors Fibroblast Growth Factors - metabolism Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Ligands Male Male genital diseases Medical sciences Metastases Neoplasm Invasiveness Neoplasm Proteins - metabolism Nephrology. Urinary tract diseases Oligonucleotide Array Sequence Analysis - methods Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phenotype Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Fibroblast Growth Factor - antagonists & inhibitors Receptors, Fibroblast Growth Factor - metabolism Receptors, Interleukin - metabolism Similar expression to FGF Survival Analysis Tumor Cells, Cultured Tumors Tumors of the urinary system Urinary tract. Prostate gland
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