Empirical models for dosage optimization of four β-lactams in critically ill septic patients based on therapeutic drug monitoring of amikacin

The study aims to develop empirical models able to predict the pharmacokinetics (PK) of four β-lactams using the amikacin (AMK) therapeutic drug monitoring (TDM), in order to optimize their dosage regimens. 69 critically ill septic patients were included. All received a first dose of AMK combined wi...

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Veröffentlicht in:	Clinical biochemistry 2010-04, Vol.43 (6), p.589-598
Hauptverfasser:	Delattre, Isabelle K., Musuamba, Flora T., Verbeeck, Roger K., Dugernier, Thierry, Spapen, Herbert, Laterre, Pierre-François, Wittebole, Xavier, Cumps, Jean, Taccone, Fabio S, Vincent, Jean-Louis, Jacobs, Frédérique, Wallemacq, Pierre E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amikacin Amikacin - administration & dosage Amikacin - pharmacokinetics Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases Bacterial sepsis beta-Lactams - administration & dosage Biological and medical sciences Calibration Critical Illness - therapy Drug Dosage Calculations Drug Monitoring - methods Drug Synergism Drug Therapy, Combination Empirical Research Female Human bacterial diseases Humans Infectious diseases Male Medical sciences Middle Aged Models, Theoretical Multivariate analysis Pharmacokinetics Pharmacology. Drug treatments Sepsis Sepsis - blood Sepsis - drug therapy Therapeutic drug monitoring Young Adult β-lactams
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