Intestinal Ischemia-Reperfusion Is Attenuated by Treatment With Atenolol in Rabbits
Abstract To study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rabbits were treated with AT (1 mg · kg−1 , introvenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the sup...
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| Veröffentlicht in: | Transplantation proceedings 2010-03, Vol.42 (2), p.451-453 |
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| creator | Taha, M.O Miranda-Ferreira, R Simões, R.S Oliveira, I Modaelli-Filho, M.L Magalhães-Junior, W.F Souza, E.S Lemos, J.A.S Simões, M.C Caricati-Neto, A |
| description | Abstract To study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rabbits were treated with AT (1 mg · kg−1 , introvenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the superior mesenteric artery, and/or R (120 minutes). After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained hematoxylin and eosin for analysis by optical microscopy. Compared to the sham group, the jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R. |
| doi_str_mv | 10.1016/j.transproceed.2010.01.020 |
| format | Article |
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After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained hematoxylin and eosin for analysis by optical microscopy. Compared to the sham group, the jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2010.01.020</identifier><identifier>PMID: 20304162</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Atenolol - therapeutic use ; Biological and medical sciences ; Blood Circulation ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gastroenterology. Liver. Pancreas. Abdomen ; Intestinal Diseases - drug therapy ; Intestinal Diseases - etiology ; Intestines - blood supply ; Jejunum - blood supply ; Jejunum - drug effects ; Jejunum - physiology ; Male ; Medical sciences ; Mesenteric Artery, Superior - physiology ; Muscle Contraction - drug effects ; Muscle Contraction - physiology ; Other diseases. Semiology ; Potassium Chloride - pharmacology ; Rabbits ; Reperfusion Injury - drug therapy ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology</subject><ispartof>Transplantation proceedings, 2010-03, Vol.42 (2), p.451-453</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-4e57af9ed14114a261a2b19787eaf8afba0e9315ffbfeab5b813aeb8ddf37e433</citedby><cites>FETCH-LOGICAL-c464t-4e57af9ed14114a261a2b19787eaf8afba0e9315ffbfeab5b813aeb8ddf37e433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134510001107$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22744837$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20304162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taha, M.O</creatorcontrib><creatorcontrib>Miranda-Ferreira, R</creatorcontrib><creatorcontrib>Simões, R.S</creatorcontrib><creatorcontrib>Oliveira, I</creatorcontrib><creatorcontrib>Modaelli-Filho, M.L</creatorcontrib><creatorcontrib>Magalhães-Junior, W.F</creatorcontrib><creatorcontrib>Souza, E.S</creatorcontrib><creatorcontrib>Lemos, J.A.S</creatorcontrib><creatorcontrib>Simões, M.C</creatorcontrib><creatorcontrib>Caricati-Neto, A</creatorcontrib><title>Intestinal Ischemia-Reperfusion Is Attenuated by Treatment With Atenolol in Rabbits</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract To study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rabbits were treated with AT (1 mg · kg−1 , introvenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the superior mesenteric artery, and/or R (120 minutes). After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained hematoxylin and eosin for analysis by optical microscopy. Compared to the sham group, the jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R.</description><subject>Animals</subject><subject>Atenolol - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Circulation</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Intestinal Diseases - drug therapy</subject><subject>Intestinal Diseases - etiology</subject><subject>Intestines - blood supply</subject><subject>Jejunum - blood supply</subject><subject>Jejunum - drug effects</subject><subject>Jejunum - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenteric Artery, Superior - physiology</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Contraction - physiology</subject><subject>Other diseases. Semiology</subject><subject>Potassium Chloride - pharmacology</subject><subject>Rabbits</subject><subject>Reperfusion Injury - drug therapy</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Intestinal Diseases - drug therapy</topic><topic>Intestinal Diseases - etiology</topic><topic>Intestines - blood supply</topic><topic>Jejunum - blood supply</topic><topic>Jejunum - drug effects</topic><topic>Jejunum - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesenteric Artery, Superior - physiology</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle Contraction - physiology</topic><topic>Other diseases. Semiology</topic><topic>Potassium Chloride - pharmacology</topic><topic>Rabbits</topic><topic>Reperfusion Injury - drug therapy</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. 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After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained hematoxylin and eosin for analysis by optical microscopy. Compared to the sham group, the jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20304162</pmid><doi>10.1016/j.transproceed.2010.01.020</doi><tpages>3</tpages></addata></record> |
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| subjects | Animals Atenolol - therapeutic use Biological and medical sciences Blood Circulation Electric Stimulation Fundamental and applied biological sciences. Psychology Fundamental immunology Gastroenterology. Liver. Pancreas. Abdomen Intestinal Diseases - drug therapy Intestinal Diseases - etiology Intestines - blood supply Jejunum - blood supply Jejunum - drug effects Jejunum - physiology Male Medical sciences Mesenteric Artery, Superior - physiology Muscle Contraction - drug effects Muscle Contraction - physiology Other diseases. Semiology Potassium Chloride - pharmacology Rabbits Reperfusion Injury - drug therapy Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology |
| title | Intestinal Ischemia-Reperfusion Is Attenuated by Treatment With Atenolol in Rabbits |
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