Anti-influenza virus principles from Muehlenbeckia hastulata
Extracts of Chilean medicinal plants were evaluated in vitro for their activities against influenza virus proliferation in MDCK cells. The most potent extract obtained was from Muehlenbeckia hastulata (Polygonaceae), known as Quilo in Chile, from which three active principles were isolated and ident...
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| Veröffentlicht in: | Journal of natural medicines 2010-04, Vol.64 (2), p.206-211 |
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| container_title | Journal of natural medicines |
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| creator | Yasuda, Takaaki Yamaki, Mitsuo Iimura, Akiko Shimotai, Yoshitaka Shimizu, Kazufumi Noshita, Toshiro Funayama, Shinji |
| description | Extracts of Chilean medicinal plants were evaluated in vitro for their activities against influenza virus proliferation in MDCK cells. The most potent extract obtained was from
Muehlenbeckia hastulata
(Polygonaceae), known as Quilo in Chile, from which three active principles were isolated and identified as pheophorbide a (
1
), hypericin (
2
) and protohypericin (
3
). Minimum inhibitory concentration (MIC) values of 42 ng/ml for compound
1
, 2.1 ng/ml for compound
2
and 1.5 ng/ml for the authentic hypericin were determined by using an endpoint assay which comprises pre-incubation of serially diluted specimens with a given amount of the influenza virus, incubation of the pre-incubated virus/specimen with MDCK cells and determination of the hemagglutination (HA) titer of the culture supernatant. Compound
3
was easily converted to
2
on exposure to visible light and, in due course, showed an anti-influenza virus activity (3.1 ng/ml) similar to
2
. Although compounds
1
–
3
were previously isolated from other plants, this is the first report of their isolation from
M. hastulata
. The high content of
1
(0.06% dry weight of whole plant) is noteworthy. In addition, this is the first report on the isolation of compounds
2
and
3
from a plant other than the genus
Hypericum
. |
| doi_str_mv | 10.1007/s11418-009-0386-9 |
| format | Article |
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Muehlenbeckia hastulata
(Polygonaceae), known as Quilo in Chile, from which three active principles were isolated and identified as pheophorbide a (
1
), hypericin (
2
) and protohypericin (
3
). Minimum inhibitory concentration (MIC) values of 42 ng/ml for compound
1
, 2.1 ng/ml for compound
2
and 1.5 ng/ml for the authentic hypericin were determined by using an endpoint assay which comprises pre-incubation of serially diluted specimens with a given amount of the influenza virus, incubation of the pre-incubated virus/specimen with MDCK cells and determination of the hemagglutination (HA) titer of the culture supernatant. Compound
3
was easily converted to
2
on exposure to visible light and, in due course, showed an anti-influenza virus activity (3.1 ng/ml) similar to
2
. Although compounds
1
–
3
were previously isolated from other plants, this is the first report of their isolation from
M. hastulata
. The high content of
1
(0.06% dry weight of whole plant) is noteworthy. In addition, this is the first report on the isolation of compounds
2
and
3
from a plant other than the genus
Hypericum
.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-009-0386-9</identifier><identifier>PMID: 20082146</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Animals ; Antiviral Agents - isolation & purification ; Antiviral Agents - pharmacology ; Biomedical and Life Sciences ; Biomedicine ; Cell Line ; Chickens ; Chile ; Complementary & Alternative Medicine ; Dogs ; Humans ; Medicinal Chemistry ; Microbial Sensitivity Tests ; Orthomyxoviridae - drug effects ; Orthomyxoviridae - growth & development ; Pharmacology/Toxicology ; Pharmacy ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Sciences ; Plants, Medicinal ; Polygonaceae</subject><ispartof>Journal of natural medicines, 2010-04, Vol.64 (2), p.206-211</ispartof><rights>The Japanese Society of Pharmacognosy and Springer 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-e01c1b165883992eb36fe83e664638aa3f3647d37e44c3c909d59cb88819457d3</citedby><cites>FETCH-LOGICAL-c367t-e01c1b165883992eb36fe83e664638aa3f3647d37e44c3c909d59cb88819457d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-009-0386-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-009-0386-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20082146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yasuda, Takaaki</creatorcontrib><creatorcontrib>Yamaki, Mitsuo</creatorcontrib><creatorcontrib>Iimura, Akiko</creatorcontrib><creatorcontrib>Shimotai, Yoshitaka</creatorcontrib><creatorcontrib>Shimizu, Kazufumi</creatorcontrib><creatorcontrib>Noshita, Toshiro</creatorcontrib><creatorcontrib>Funayama, Shinji</creatorcontrib><title>Anti-influenza virus principles from Muehlenbeckia hastulata</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>Extracts of Chilean medicinal plants were evaluated in vitro for their activities against influenza virus proliferation in MDCK cells. The most potent extract obtained was from
Muehlenbeckia hastulata
(Polygonaceae), known as Quilo in Chile, from which three active principles were isolated and identified as pheophorbide a (
1
), hypericin (
2
) and protohypericin (
3
). Minimum inhibitory concentration (MIC) values of 42 ng/ml for compound
1
, 2.1 ng/ml for compound
2
and 1.5 ng/ml for the authentic hypericin were determined by using an endpoint assay which comprises pre-incubation of serially diluted specimens with a given amount of the influenza virus, incubation of the pre-incubated virus/specimen with MDCK cells and determination of the hemagglutination (HA) titer of the culture supernatant. Compound
3
was easily converted to
2
on exposure to visible light and, in due course, showed an anti-influenza virus activity (3.1 ng/ml) similar to
2
. Although compounds
1
–
3
were previously isolated from other plants, this is the first report of their isolation from
M. hastulata
. The high content of
1
(0.06% dry weight of whole plant) is noteworthy. In addition, this is the first report on the isolation of compounds
2
and
3
from a plant other than the genus
Hypericum
.</description><subject>Animals</subject><subject>Antiviral Agents - isolation & purification</subject><subject>Antiviral Agents - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Line</subject><subject>Chickens</subject><subject>Chile</subject><subject>Complementary & Alternative Medicine</subject><subject>Dogs</subject><subject>Humans</subject><subject>Medicinal Chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Orthomyxoviridae - drug effects</subject><subject>Orthomyxoviridae - growth & development</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Sciences</subject><subject>Plants, Medicinal</subject><subject>Polygonaceae</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAWxQdqwMdsZxbIlNVfGSitjA2nLcCU3Jo9gxEnw9qVJYspqR5twrzSHknLMrzlh-HTgXXFHGNGWgJNUHZMqV5JSlGg6HHQSjIARMyEkIG8ZECsCPySRlTKVcyCm5mbd9Rau2rCO23zb5rHwMydZXrau2NYak9F2TPEVc19gW6N4rm6xt6GNte3tKjkpbBzzbzxl5vbt9WTzQ5fP942K-pA5k3lNk3PGCy0wp0DrFAmSJClBKIUFZCyVIka8gRyEcOM30KtOuUEpxLbLhMCOXY-_Wdx8RQ2-aKjisa9tiF4PJARRTUmUDyUfS-S4Ej6UZXmms_zKcmZ0zMzozgzOzc2b0kLnYt8eiwdVf4lfSAKQjEHZe3tCbTRd9O3z8T-sP8Ld2Dw</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Yasuda, Takaaki</creator><creator>Yamaki, Mitsuo</creator><creator>Iimura, Akiko</creator><creator>Shimotai, Yoshitaka</creator><creator>Shimizu, Kazufumi</creator><creator>Noshita, Toshiro</creator><creator>Funayama, Shinji</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100401</creationdate><title>Anti-influenza virus principles from Muehlenbeckia hastulata</title><author>Yasuda, Takaaki ; Yamaki, Mitsuo ; Iimura, Akiko ; Shimotai, Yoshitaka ; Shimizu, Kazufumi ; Noshita, Toshiro ; Funayama, Shinji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-e01c1b165883992eb36fe83e664638aa3f3647d37e44c3c909d59cb88819457d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antiviral Agents - isolation & purification</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Line</topic><topic>Chickens</topic><topic>Chile</topic><topic>Complementary & Alternative Medicine</topic><topic>Dogs</topic><topic>Humans</topic><topic>Medicinal Chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Orthomyxoviridae - drug effects</topic><topic>Orthomyxoviridae - growth & development</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Sciences</topic><topic>Plants, Medicinal</topic><topic>Polygonaceae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yasuda, Takaaki</creatorcontrib><creatorcontrib>Yamaki, Mitsuo</creatorcontrib><creatorcontrib>Iimura, Akiko</creatorcontrib><creatorcontrib>Shimotai, Yoshitaka</creatorcontrib><creatorcontrib>Shimizu, Kazufumi</creatorcontrib><creatorcontrib>Noshita, Toshiro</creatorcontrib><creatorcontrib>Funayama, Shinji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yasuda, Takaaki</au><au>Yamaki, Mitsuo</au><au>Iimura, Akiko</au><au>Shimotai, Yoshitaka</au><au>Shimizu, Kazufumi</au><au>Noshita, Toshiro</au><au>Funayama, Shinji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-influenza virus principles from Muehlenbeckia hastulata</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>64</volume><issue>2</issue><spage>206</spage><epage>211</epage><pages>206-211</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>Extracts of Chilean medicinal plants were evaluated in vitro for their activities against influenza virus proliferation in MDCK cells. The most potent extract obtained was from
Muehlenbeckia hastulata
(Polygonaceae), known as Quilo in Chile, from which three active principles were isolated and identified as pheophorbide a (
1
), hypericin (
2
) and protohypericin (
3
). Minimum inhibitory concentration (MIC) values of 42 ng/ml for compound
1
, 2.1 ng/ml for compound
2
and 1.5 ng/ml for the authentic hypericin were determined by using an endpoint assay which comprises pre-incubation of serially diluted specimens with a given amount of the influenza virus, incubation of the pre-incubated virus/specimen with MDCK cells and determination of the hemagglutination (HA) titer of the culture supernatant. Compound
3
was easily converted to
2
on exposure to visible light and, in due course, showed an anti-influenza virus activity (3.1 ng/ml) similar to
2
. Although compounds
1
–
3
were previously isolated from other plants, this is the first report of their isolation from
M. hastulata
. The high content of
1
(0.06% dry weight of whole plant) is noteworthy. In addition, this is the first report on the isolation of compounds
2
and
3
from a plant other than the genus
Hypericum
.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>20082146</pmid><doi>10.1007/s11418-009-0386-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Biomedical and Life Sciences Biomedicine Cell Line Chickens Chile Complementary & Alternative Medicine Dogs Humans Medicinal Chemistry Microbial Sensitivity Tests Orthomyxoviridae - drug effects Orthomyxoviridae - growth & development Pharmacology/Toxicology Pharmacy Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Sciences Plants, Medicinal Polygonaceae |
| title | Anti-influenza virus principles from Muehlenbeckia hastulata |
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