Effects of 5′-Adenosine Triphosphate on Intestinal Ischemia-Reperfusion in Rabbits
Abstract To study whether treatment with 5′-adenosine triphosphate (ATP), an agonist of P2 purine receptors, attenuated intestinal dysfunction caused by ischemia (I) and/or reperfusion (R), rabbits were treated with ATP (15 mg · kg−1 , intravenously) or saline solution (SS) 60 minutes before I by oc...
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| Veröffentlicht in: | Transplantation proceedings 2010-03, Vol.42 (2), p.461-464 |
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| creator | Taha, M.O Miranda-Ferreira, R Fagundes, D.J Simões, R.S Monteiro, H.P Oliveira, I.S Soares, K.R.M Martins, M.C.L Balbino, A.T Rodrigues, F.F Arruda, T.B Abrão, M.S Jurkiewicz, A Caricati-Neto, A |
| description | Abstract To study whether treatment with 5′-adenosine triphosphate (ATP), an agonist of P2 purine receptors, attenuated intestinal dysfunction caused by ischemia (I) and/or reperfusion (R), rabbits were treated with ATP (15 mg · kg−1 , intravenously) or saline solution (SS) 60 minutes before I by occlusion of the superior mesenteric artery and/or R (120 minutes). After I or I/R isolated 2-cm jejunal segments were mounted in an organ bath to study nerve-mediated contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained (hematoxylin and eosin) for optical microscopy. Compared to a sham group, the jejunal contractions were similar to sham hosts among I + ATP, but reduced in I + SS, I/R + SS, and I/R + ATP groups. The jejunal-enteric nerves were damaged in I + SS, I/R + SS, and I/R + ATP, but not the I + ATP group. These results suggested that ATP attenuated intestinal dysfunction produced by I, but not that caused by R. |
| doi_str_mv | 10.1016/j.transproceed.2010.01.036 |
| format | Article |
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After I or I/R isolated 2-cm jejunal segments were mounted in an organ bath to study nerve-mediated contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained (hematoxylin and eosin) for optical microscopy. Compared to a sham group, the jejunal contractions were similar to sham hosts among I + ATP, but reduced in I + SS, I/R + SS, and I/R + ATP groups. The jejunal-enteric nerves were damaged in I + SS, I/R + SS, and I/R + ATP, but not the I + ATP group. These results suggested that ATP attenuated intestinal dysfunction produced by I, but not that caused by R.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2010.01.036</identifier><identifier>PMID: 20304165</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adenosine Triphosphate - pharmacology ; Animals ; Biological and medical sciences ; Blood Circulation - drug effects ; Blood Circulation - physiology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gastroenterology. Liver. Pancreas. Abdomen ; Intestines - blood supply ; Ischemia - drug therapy ; Ischemia - physiopathology ; Jejunum - blood supply ; Jejunum - drug effects ; Jejunum - innervation ; Male ; Medical sciences ; Mesenteric Artery, Superior - drug effects ; Mesenteric Artery, Superior - physiopathology ; Other diseases. Semiology ; Rabbits ; Reperfusion Injury - physiopathology ; Sodium Chloride - pharmacology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology</subject><ispartof>Transplantation proceedings, 2010-03, Vol.42 (2), p.461-464</ispartof><rights>2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-f930ffe2758436656ace8062d8f6376347aace508c5cf5691122a5fef64a20e13</citedby><cites>FETCH-LOGICAL-c464t-f930ffe2758436656ace8062d8f6376347aace508c5cf5691122a5fef64a20e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134510001272$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22744840$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20304165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taha, M.O</creatorcontrib><creatorcontrib>Miranda-Ferreira, R</creatorcontrib><creatorcontrib>Fagundes, D.J</creatorcontrib><creatorcontrib>Simões, R.S</creatorcontrib><creatorcontrib>Monteiro, H.P</creatorcontrib><creatorcontrib>Oliveira, I.S</creatorcontrib><creatorcontrib>Soares, K.R.M</creatorcontrib><creatorcontrib>Martins, M.C.L</creatorcontrib><creatorcontrib>Balbino, A.T</creatorcontrib><creatorcontrib>Rodrigues, F.F</creatorcontrib><creatorcontrib>Arruda, T.B</creatorcontrib><creatorcontrib>Abrão, M.S</creatorcontrib><creatorcontrib>Jurkiewicz, A</creatorcontrib><creatorcontrib>Caricati-Neto, A</creatorcontrib><title>Effects of 5′-Adenosine Triphosphate on Intestinal Ischemia-Reperfusion in Rabbits</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract To study whether treatment with 5′-adenosine triphosphate (ATP), an agonist of P2 purine receptors, attenuated intestinal dysfunction caused by ischemia (I) and/or reperfusion (R), rabbits were treated with ATP (15 mg · kg−1 , intravenously) or saline solution (SS) 60 minutes before I by occlusion of the superior mesenteric artery and/or R (120 minutes). After I or I/R isolated 2-cm jejunal segments were mounted in an organ bath to study nerve-mediated contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained (hematoxylin and eosin) for optical microscopy. Compared to a sham group, the jejunal contractions were similar to sham hosts among I + ATP, but reduced in I + SS, I/R + SS, and I/R + ATP groups. The jejunal-enteric nerves were damaged in I + SS, I/R + SS, and I/R + ATP, but not the I + ATP group. These results suggested that ATP attenuated intestinal dysfunction produced by I, but not that caused by R.</description><subject>Adenosine Triphosphate - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Circulation - drug effects</subject><subject>Blood Circulation - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Intestines - blood supply</subject><subject>Ischemia - drug therapy</subject><subject>Ischemia - physiopathology</subject><subject>Jejunum - blood supply</subject><subject>Jejunum - drug effects</subject><subject>Jejunum - innervation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenteric Artery, Superior - drug effects</subject><subject>Mesenteric Artery, Superior - physiopathology</subject><subject>Other diseases. Semiology</subject><subject>Rabbits</subject><subject>Reperfusion Injury - physiopathology</subject><subject>Sodium Chloride - pharmacology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Intestines - blood supply</topic><topic>Ischemia - drug therapy</topic><topic>Ischemia - physiopathology</topic><topic>Jejunum - blood supply</topic><topic>Jejunum - drug effects</topic><topic>Jejunum - innervation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesenteric Artery, Superior - drug effects</topic><topic>Mesenteric Artery, Superior - physiopathology</topic><topic>Other diseases. Semiology</topic><topic>Rabbits</topic><topic>Reperfusion Injury - physiopathology</topic><topic>Sodium Chloride - pharmacology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. 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After I or I/R isolated 2-cm jejunal segments were mounted in an organ bath to study nerve-mediated contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained (hematoxylin and eosin) for optical microscopy. Compared to a sham group, the jejunal contractions were similar to sham hosts among I + ATP, but reduced in I + SS, I/R + SS, and I/R + ATP groups. The jejunal-enteric nerves were damaged in I + SS, I/R + SS, and I/R + ATP, but not the I + ATP group. These results suggested that ATP attenuated intestinal dysfunction produced by I, but not that caused by R.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20304165</pmid><doi>10.1016/j.transproceed.2010.01.036</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenosine Triphosphate - pharmacology Animals Biological and medical sciences Blood Circulation - drug effects Blood Circulation - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Gastroenterology. Liver. Pancreas. Abdomen Intestines - blood supply Ischemia - drug therapy Ischemia - physiopathology Jejunum - blood supply Jejunum - drug effects Jejunum - innervation Male Medical sciences Mesenteric Artery, Superior - drug effects Mesenteric Artery, Superior - physiopathology Other diseases. Semiology Rabbits Reperfusion Injury - physiopathology Sodium Chloride - pharmacology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology |
| title | Effects of 5′-Adenosine Triphosphate on Intestinal Ischemia-Reperfusion in Rabbits |
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