Histopathologic Characteristics of Incidental Hepatocellular Carcinoma After Liver Transplantation
Abstract Introduction Liver transplantation for patients with hepatocellular carcinoma (HCC) is an accepted therapeutic modality, depending on the size and number of nodules. Since a high incidence of incidental HCC at transplantation has been reported, our aim was to evaluate the histopathologic ch...
Gespeichert in:
| Veröffentlicht in: | Transplantation proceedings 2010-03, Vol.42 (2), p.505-506 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 506 |
|---|---|
| container_issue | 2 |
| container_start_page | 505 |
| container_title | Transplantation proceedings |
| container_volume | 42 |
| creator | Raphe, R Felício, H.C.C Rocha, M.F Duca, W.J Arroyo, P.C D'Santi Neto, D da Silva, R.C.M.A da Silva, R.F |
| description | Abstract Introduction Liver transplantation for patients with hepatocellular carcinoma (HCC) is an accepted therapeutic modality, depending on the size and number of nodules. Since a high incidence of incidental HCC at transplantation has been reported, our aim was to evaluate the histopathologic characteristics of these patients. Patients and methods This retrospective analysis from March 1998 to June 2009 included liver transplantation patients without increased alpha-fetoprotein or nodules on imaging methods. We included patients with HCC on anatomopathologic exam, excluding those presenting with HCC on the presurgery evaluation through clinical, laboratory and imaging methods. Results Among the 277 transplanted subjects, 27 showed incidental HCC. The alpha-fetoprotein average level was 8.52 mg/dL (1.6–28.2). One patient presented with adenomatosis and focus of HCC. Histopathologic analyses showed: mean tumor size was 0.9 cm (range = 0.4–3.5); average number of tumors in each explanted liver 1.85 (range = 1–7) nodules; and three (11.1%), microvascular invasion (11.1%). The TNM staging showed 17 (63%) stage I and 6 (22%) stage II. The Edmondson and Steiner classification showed 19 (70%) subjects in degree II. Conclusion The histopathologic presentation of incidental HCC after liver transplantation showed tumors in early stage with microvascular invasion in some cases. |
| doi_str_mv | 10.1016/j.transproceed.2010.01.034 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733808569</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0041134510001259</els_id><sourcerecordid>733808569</sourcerecordid><originalsourceid>FETCH-LOGICAL-c464t-2ac65a0fa47254eec202098b97e2fc891c55eb240c25dd22a7b9ed4a119de2b53</originalsourceid><addsrcrecordid>eNqNkkuLFDEQgIMo7rj6F6QRxFOPefbDg7CMj1kY8OB6DtXpajdjpjMm3Qv77612ZlE8eUlI6qsHH8XYK8HXgovq7X49JRjzMUWH2K8lpwAXa670I7YSTa1KWUn1mK0416IUSpsL9iznPae31Oopu5BcUahuVqzb-jzFI0y3McTv3hWbW0jgJkz0710u4lBcj873OE4Qii0SSm1DmAOkYgPJ-TEeoLgaKKXY-Ts6b35PF4AyJh_H5-zJACHji_N9yb59-niz2Za7L5-vN1e70ulKT6UEVxngA-haGo3oJJe8bbq2Rjm4phXOGOyk5k6avpcS6q7FXoMQbY-yM-qSvTnVJTE_Z8yTPfi8jAojxjnbWqmGN6ZqiXx3Il2KOScc7DH5A6R7K7hdFNu9_VuxXRRbLiwppuSX5zZzd6DYQ-qDUwJenwHIDsJAhZzPfzhZa90YRdyHE4ck5c5jstl5HB32PqGbbB_9_83z_p8yLvjRU-cfeI95H-c0knYrbJaW26_LUiw7IWgdhDSt-gUiArfL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733808569</pqid></control><display><type>article</type><title>Histopathologic Characteristics of Incidental Hepatocellular Carcinoma After Liver Transplantation</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Raphe, R ; Felício, H.C.C ; Rocha, M.F ; Duca, W.J ; Arroyo, P.C ; D'Santi Neto, D ; da Silva, R.C.M.A ; da Silva, R.F</creator><creatorcontrib>Raphe, R ; Felício, H.C.C ; Rocha, M.F ; Duca, W.J ; Arroyo, P.C ; D'Santi Neto, D ; da Silva, R.C.M.A ; da Silva, R.F</creatorcontrib><description>Abstract Introduction Liver transplantation for patients with hepatocellular carcinoma (HCC) is an accepted therapeutic modality, depending on the size and number of nodules. Since a high incidence of incidental HCC at transplantation has been reported, our aim was to evaluate the histopathologic characteristics of these patients. Patients and methods This retrospective analysis from March 1998 to June 2009 included liver transplantation patients without increased alpha-fetoprotein or nodules on imaging methods. We included patients with HCC on anatomopathologic exam, excluding those presenting with HCC on the presurgery evaluation through clinical, laboratory and imaging methods. Results Among the 277 transplanted subjects, 27 showed incidental HCC. The alpha-fetoprotein average level was 8.52 mg/dL (1.6–28.2). One patient presented with adenomatosis and focus of HCC. Histopathologic analyses showed: mean tumor size was 0.9 cm (range = 0.4–3.5); average number of tumors in each explanted liver 1.85 (range = 1–7) nodules; and three (11.1%), microvascular invasion (11.1%). The TNM staging showed 17 (63%) stage I and 6 (22%) stage II. The Edmondson and Steiner classification showed 19 (70%) subjects in degree II. Conclusion The histopathologic presentation of incidental HCC after liver transplantation showed tumors in early stage with microvascular invasion in some cases.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2010.01.034</identifier><identifier>PMID: 20304178</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>alpha-Fetoproteins - metabolism ; Biological and medical sciences ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Incidence ; Liver Neoplasms - epidemiology ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Liver Transplantation - adverse effects ; Liver, biliary tract, pancreas, portal circulation, spleen ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Neoplasm Invasiveness ; Neoplasm Staging ; Postoperative Complications - epidemiology ; Retrospective Studies ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Tissue, organ and graft immunology ; Tumors</subject><ispartof>Transplantation proceedings, 2010-03, Vol.42 (2), p.505-506</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-2ac65a0fa47254eec202098b97e2fc891c55eb240c25dd22a7b9ed4a119de2b53</citedby><cites>FETCH-LOGICAL-c464t-2ac65a0fa47254eec202098b97e2fc891c55eb240c25dd22a7b9ed4a119de2b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2010.01.034$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22744853$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20304178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raphe, R</creatorcontrib><creatorcontrib>Felício, H.C.C</creatorcontrib><creatorcontrib>Rocha, M.F</creatorcontrib><creatorcontrib>Duca, W.J</creatorcontrib><creatorcontrib>Arroyo, P.C</creatorcontrib><creatorcontrib>D'Santi Neto, D</creatorcontrib><creatorcontrib>da Silva, R.C.M.A</creatorcontrib><creatorcontrib>da Silva, R.F</creatorcontrib><title>Histopathologic Characteristics of Incidental Hepatocellular Carcinoma After Liver Transplantation</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Introduction Liver transplantation for patients with hepatocellular carcinoma (HCC) is an accepted therapeutic modality, depending on the size and number of nodules. Since a high incidence of incidental HCC at transplantation has been reported, our aim was to evaluate the histopathologic characteristics of these patients. Patients and methods This retrospective analysis from March 1998 to June 2009 included liver transplantation patients without increased alpha-fetoprotein or nodules on imaging methods. We included patients with HCC on anatomopathologic exam, excluding those presenting with HCC on the presurgery evaluation through clinical, laboratory and imaging methods. Results Among the 277 transplanted subjects, 27 showed incidental HCC. The alpha-fetoprotein average level was 8.52 mg/dL (1.6–28.2). One patient presented with adenomatosis and focus of HCC. Histopathologic analyses showed: mean tumor size was 0.9 cm (range = 0.4–3.5); average number of tumors in each explanted liver 1.85 (range = 1–7) nodules; and three (11.1%), microvascular invasion (11.1%). The TNM staging showed 17 (63%) stage I and 6 (22%) stage II. The Edmondson and Steiner classification showed 19 (70%) subjects in degree II. Conclusion The histopathologic presentation of incidental HCC after liver transplantation showed tumors in early stage with microvascular invasion in some cases.</description><subject>alpha-Fetoproteins - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Incidence</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Transplantation - adverse effects</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Postoperative Complications - epidemiology</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Tissue, organ and graft immunology</subject><subject>Tumors</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkuLFDEQgIMo7rj6F6QRxFOPefbDg7CMj1kY8OB6DtXpajdjpjMm3Qv77612ZlE8eUlI6qsHH8XYK8HXgovq7X49JRjzMUWH2K8lpwAXa670I7YSTa1KWUn1mK0416IUSpsL9iznPae31Oopu5BcUahuVqzb-jzFI0y3McTv3hWbW0jgJkz0710u4lBcj873OE4Qii0SSm1DmAOkYgPJ-TEeoLgaKKXY-Ts6b35PF4AyJh_H5-zJACHji_N9yb59-niz2Za7L5-vN1e70ulKT6UEVxngA-haGo3oJJe8bbq2Rjm4phXOGOyk5k6avpcS6q7FXoMQbY-yM-qSvTnVJTE_Z8yTPfi8jAojxjnbWqmGN6ZqiXx3Il2KOScc7DH5A6R7K7hdFNu9_VuxXRRbLiwppuSX5zZzd6DYQ-qDUwJenwHIDsJAhZzPfzhZa90YRdyHE4ck5c5jstl5HB32PqGbbB_9_83z_p8yLvjRU-cfeI95H-c0knYrbJaW26_LUiw7IWgdhDSt-gUiArfL</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Raphe, R</creator><creator>Felício, H.C.C</creator><creator>Rocha, M.F</creator><creator>Duca, W.J</creator><creator>Arroyo, P.C</creator><creator>D'Santi Neto, D</creator><creator>da Silva, R.C.M.A</creator><creator>da Silva, R.F</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>Histopathologic Characteristics of Incidental Hepatocellular Carcinoma After Liver Transplantation</title><author>Raphe, R ; Felício, H.C.C ; Rocha, M.F ; Duca, W.J ; Arroyo, P.C ; D'Santi Neto, D ; da Silva, R.C.M.A ; da Silva, R.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-2ac65a0fa47254eec202098b97e2fc891c55eb240c25dd22a7b9ed4a119de2b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>alpha-Fetoproteins - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Incidence</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver Transplantation - adverse effects</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Postoperative Complications - epidemiology</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Tissue, organ and graft immunology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raphe, R</creatorcontrib><creatorcontrib>Felício, H.C.C</creatorcontrib><creatorcontrib>Rocha, M.F</creatorcontrib><creatorcontrib>Duca, W.J</creatorcontrib><creatorcontrib>Arroyo, P.C</creatorcontrib><creatorcontrib>D'Santi Neto, D</creatorcontrib><creatorcontrib>da Silva, R.C.M.A</creatorcontrib><creatorcontrib>da Silva, R.F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raphe, R</au><au>Felício, H.C.C</au><au>Rocha, M.F</au><au>Duca, W.J</au><au>Arroyo, P.C</au><au>D'Santi Neto, D</au><au>da Silva, R.C.M.A</au><au>da Silva, R.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathologic Characteristics of Incidental Hepatocellular Carcinoma After Liver Transplantation</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>42</volume><issue>2</issue><spage>505</spage><epage>506</epage><pages>505-506</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Introduction Liver transplantation for patients with hepatocellular carcinoma (HCC) is an accepted therapeutic modality, depending on the size and number of nodules. Since a high incidence of incidental HCC at transplantation has been reported, our aim was to evaluate the histopathologic characteristics of these patients. Patients and methods This retrospective analysis from March 1998 to June 2009 included liver transplantation patients without increased alpha-fetoprotein or nodules on imaging methods. We included patients with HCC on anatomopathologic exam, excluding those presenting with HCC on the presurgery evaluation through clinical, laboratory and imaging methods. Results Among the 277 transplanted subjects, 27 showed incidental HCC. The alpha-fetoprotein average level was 8.52 mg/dL (1.6–28.2). One patient presented with adenomatosis and focus of HCC. Histopathologic analyses showed: mean tumor size was 0.9 cm (range = 0.4–3.5); average number of tumors in each explanted liver 1.85 (range = 1–7) nodules; and three (11.1%), microvascular invasion (11.1%). The TNM staging showed 17 (63%) stage I and 6 (22%) stage II. The Edmondson and Steiner classification showed 19 (70%) subjects in degree II. Conclusion The histopathologic presentation of incidental HCC after liver transplantation showed tumors in early stage with microvascular invasion in some cases.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20304178</pmid><doi>10.1016/j.transproceed.2010.01.034</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1345 |
| ispartof | Transplantation proceedings, 2010-03, Vol.42 (2), p.505-506 |
| issn | 0041-1345 1873-2623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733808569 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | alpha-Fetoproteins - metabolism Biological and medical sciences Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Fundamental and applied biological sciences. Psychology Fundamental immunology Gastroenterology. Liver. Pancreas. Abdomen Humans Incidence Liver Neoplasms - epidemiology Liver Neoplasms - pathology Liver Neoplasms - surgery Liver Transplantation - adverse effects Liver, biliary tract, pancreas, portal circulation, spleen Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Neoplasm Invasiveness Neoplasm Staging Postoperative Complications - epidemiology Retrospective Studies Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tissue, organ and graft immunology Tumors |
| title | Histopathologic Characteristics of Incidental Hepatocellular Carcinoma After Liver Transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T22%3A53%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Histopathologic%20Characteristics%20of%20Incidental%20Hepatocellular%20Carcinoma%20After%20Liver%20Transplantation&rft.jtitle=Transplantation%20proceedings&rft.au=Raphe,%20R&rft.date=2010-03-01&rft.volume=42&rft.issue=2&rft.spage=505&rft.epage=506&rft.pages=505-506&rft.issn=0041-1345&rft.eissn=1873-2623&rft.coden=TRPPA8&rft_id=info:doi/10.1016/j.transproceed.2010.01.034&rft_dat=%3Cproquest_cross%3E733808569%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733808569&rft_id=info:pmid/20304178&rft_els_id=S0041134510001259&rfr_iscdi=true |