How Activity of Inflammatory Bowel Disease Influences Bone Loss
Abstract Bone loss is a common problem for individuals with inflammatory bowel disease (IBD). The aim of our study was to assess bone mineral density (BMD) in patients with IBD and to investigate the role of corticosteroid (CS) use and duration and activity of disease on BMD. Ninety-two patients (56...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical densitometry 2010, Vol.13 (1), p.36-42 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 42 |
|---|---|
| container_issue | 1 |
| container_start_page | 36 |
| container_title | Journal of clinical densitometry |
| container_volume | 13 |
| creator | Orlic, Zeljka Crncevic Turk, Tamara Sincic, Brankica Mijandrusic Stimac, Davor Cvijanovic, Olga Maric, Ivana Tomas, Maja Ilic Jurisic-Erzen, Dubravka Licul, Vanja Bobinac, Dragica |
| description | Abstract Bone loss is a common problem for individuals with inflammatory bowel disease (IBD). The aim of our study was to assess bone mineral density (BMD) in patients with IBD and to investigate the role of corticosteroid (CS) use and duration and activity of disease on BMD. Ninety-two patients (56 men and 36 women) with IBD, of whom 32 had ulcerative colitis (UC) and 60 had Crohn's disease (CD), underwent clinical assessment. Lumbar and femoral neck BMDs were measured by dual-energy X-ray absorptiometry. Osteopenia was observed in 14 patients (43%) with UC and in 24 patients (40%) with CD ( p = 0.187). Four patients (12%) with UC and 7 patients (11%) with CD had osteoporosis ( p = 0.308). Femoral BMD decreased in patients with long duration of CS use and correlated inversely with disease activity. Multiple regression analysis of BMD showed that statistically significant risk factors were duration of active disease and body mass index as well. Based on our results, it is necessary to take into account the risk of decreased BMD in patients with IBD. It is most important to achieve disease remission as soon as possible in addition to nutritional support. |
| doi_str_mv | 10.1016/j.jocd.2009.12.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733808191</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1094695009002716</els_id><sourcerecordid>733808191</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-d7057b08f1128ea35fe69781d145c85fdf06f481bb591c2d1c0672f18ad2915f3</originalsourceid><addsrcrecordid>eNp9kcFu1TAQRS0EoqXwAyxQdqySepw4tiUEagullZ7EAlhbfvZYckjiYiet3t_j8AoLFqxsac69ss8Q8hpoAxT686EZonUNo1Q1wBpK2RNyCpyrmopOPC13qrq6V5yekBc5DwUAkOI5OWEUBPBenJIPN_GhurBLuA_LoYq-up39aKbJLDEdqsv4gGP1MWQ0GX-PVpwt5jKYsdrFnF-SZ96MGV89nmfk-_Wnb1c39e7L59uri11tO6BL7QTlYk-lB2ASTcs99kpIcNBxK7l3nva-k7DfcwWWObC0F8yDNI4p4L49I2-PvXcp_lwxL3oK2eI4mhnjmrVoW0klKCgkO5I2lfcl9PouhcmkgwaqN2960Js3vXnTwHTRUkJvHuvX_YTub-SPqAK8OwJYPnkfMOlsw-bChYR20S6G__e__yduxzAHa8YfeMA8xDXNRZ8GnUtAf902ty2OqpIW0Le_AHpbkcA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733808191</pqid></control><display><type>article</type><title>How Activity of Inflammatory Bowel Disease Influences Bone Loss</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Orlic, Zeljka Crncevic ; Turk, Tamara ; Sincic, Brankica Mijandrusic ; Stimac, Davor ; Cvijanovic, Olga ; Maric, Ivana ; Tomas, Maja Ilic ; Jurisic-Erzen, Dubravka ; Licul, Vanja ; Bobinac, Dragica</creator><creatorcontrib>Orlic, Zeljka Crncevic ; Turk, Tamara ; Sincic, Brankica Mijandrusic ; Stimac, Davor ; Cvijanovic, Olga ; Maric, Ivana ; Tomas, Maja Ilic ; Jurisic-Erzen, Dubravka ; Licul, Vanja ; Bobinac, Dragica</creatorcontrib><description>Abstract Bone loss is a common problem for individuals with inflammatory bowel disease (IBD). The aim of our study was to assess bone mineral density (BMD) in patients with IBD and to investigate the role of corticosteroid (CS) use and duration and activity of disease on BMD. Ninety-two patients (56 men and 36 women) with IBD, of whom 32 had ulcerative colitis (UC) and 60 had Crohn's disease (CD), underwent clinical assessment. Lumbar and femoral neck BMDs were measured by dual-energy X-ray absorptiometry. Osteopenia was observed in 14 patients (43%) with UC and in 24 patients (40%) with CD ( p = 0.187). Four patients (12%) with UC and 7 patients (11%) with CD had osteoporosis ( p = 0.308). Femoral BMD decreased in patients with long duration of CS use and correlated inversely with disease activity. Multiple regression analysis of BMD showed that statistically significant risk factors were duration of active disease and body mass index as well. Based on our results, it is necessary to take into account the risk of decreased BMD in patients with IBD. It is most important to achieve disease remission as soon as possible in addition to nutritional support.</description><identifier>ISSN: 1094-6950</identifier><identifier>EISSN: 1559-0747</identifier><identifier>DOI: 10.1016/j.jocd.2009.12.002</identifier><identifier>PMID: 20171567</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Absorptiometry, Photon - methods ; Adult ; Aged ; Bone Density ; Bone Resorption - diagnostic imaging ; Bone Resorption - etiology ; Bone Resorption - metabolism ; Corticosteroids ; Disease Progression ; duration and activity of disease ; Endocrinology & Metabolism ; Female ; Femur - diagnostic imaging ; Femur - metabolism ; Follow-Up Studies ; Humans ; IBD ; Inflammatory Bowel Diseases - complications ; Inflammatory Bowel Diseases - metabolism ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - metabolism ; Male ; Middle Aged ; osteoporosis ; Osteoporosis - diagnostic imaging ; Osteoporosis - etiology ; Osteoporosis - metabolism ; Prognosis ; Retrospective Studies ; Time Factors ; Young Adult</subject><ispartof>Journal of clinical densitometry, 2010, Vol.13 (1), p.36-42</ispartof><rights>The International Society for Clinical Densitometry</rights><rights>2010 The International Society for Clinical Densitometry</rights><rights>Copyright (c) 2010 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-d7057b08f1128ea35fe69781d145c85fdf06f481bb591c2d1c0672f18ad2915f3</citedby><cites>FETCH-LOGICAL-c410t-d7057b08f1128ea35fe69781d145c85fdf06f481bb591c2d1c0672f18ad2915f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jocd.2009.12.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,4023,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20171567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orlic, Zeljka Crncevic</creatorcontrib><creatorcontrib>Turk, Tamara</creatorcontrib><creatorcontrib>Sincic, Brankica Mijandrusic</creatorcontrib><creatorcontrib>Stimac, Davor</creatorcontrib><creatorcontrib>Cvijanovic, Olga</creatorcontrib><creatorcontrib>Maric, Ivana</creatorcontrib><creatorcontrib>Tomas, Maja Ilic</creatorcontrib><creatorcontrib>Jurisic-Erzen, Dubravka</creatorcontrib><creatorcontrib>Licul, Vanja</creatorcontrib><creatorcontrib>Bobinac, Dragica</creatorcontrib><title>How Activity of Inflammatory Bowel Disease Influences Bone Loss</title><title>Journal of clinical densitometry</title><addtitle>J Clin Densitom</addtitle><description>Abstract Bone loss is a common problem for individuals with inflammatory bowel disease (IBD). The aim of our study was to assess bone mineral density (BMD) in patients with IBD and to investigate the role of corticosteroid (CS) use and duration and activity of disease on BMD. Ninety-two patients (56 men and 36 women) with IBD, of whom 32 had ulcerative colitis (UC) and 60 had Crohn's disease (CD), underwent clinical assessment. Lumbar and femoral neck BMDs were measured by dual-energy X-ray absorptiometry. Osteopenia was observed in 14 patients (43%) with UC and in 24 patients (40%) with CD ( p = 0.187). Four patients (12%) with UC and 7 patients (11%) with CD had osteoporosis ( p = 0.308). Femoral BMD decreased in patients with long duration of CS use and correlated inversely with disease activity. Multiple regression analysis of BMD showed that statistically significant risk factors were duration of active disease and body mass index as well. Based on our results, it is necessary to take into account the risk of decreased BMD in patients with IBD. It is most important to achieve disease remission as soon as possible in addition to nutritional support.</description><subject>Absorptiometry, Photon - methods</subject><subject>Adult</subject><subject>Aged</subject><subject>Bone Density</subject><subject>Bone Resorption - diagnostic imaging</subject><subject>Bone Resorption - etiology</subject><subject>Bone Resorption - metabolism</subject><subject>Corticosteroids</subject><subject>Disease Progression</subject><subject>duration and activity of disease</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Femur - diagnostic imaging</subject><subject>Femur - metabolism</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>IBD</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Inflammatory Bowel Diseases - metabolism</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>osteoporosis</subject><subject>Osteoporosis - diagnostic imaging</subject><subject>Osteoporosis - etiology</subject><subject>Osteoporosis - metabolism</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>1094-6950</issn><issn>1559-0747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1TAQRS0EoqXwAyxQdqySepw4tiUEagullZ7EAlhbfvZYckjiYiet3t_j8AoLFqxsac69ss8Q8hpoAxT686EZonUNo1Q1wBpK2RNyCpyrmopOPC13qrq6V5yekBc5DwUAkOI5OWEUBPBenJIPN_GhurBLuA_LoYq-up39aKbJLDEdqsv4gGP1MWQ0GX-PVpwt5jKYsdrFnF-SZ96MGV89nmfk-_Wnb1c39e7L59uri11tO6BL7QTlYk-lB2ASTcs99kpIcNBxK7l3nva-k7DfcwWWObC0F8yDNI4p4L49I2-PvXcp_lwxL3oK2eI4mhnjmrVoW0klKCgkO5I2lfcl9PouhcmkgwaqN2960Js3vXnTwHTRUkJvHuvX_YTub-SPqAK8OwJYPnkfMOlsw-bChYR20S6G__e__yduxzAHa8YfeMA8xDXNRZ8GnUtAf902ty2OqpIW0Le_AHpbkcA</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Orlic, Zeljka Crncevic</creator><creator>Turk, Tamara</creator><creator>Sincic, Brankica Mijandrusic</creator><creator>Stimac, Davor</creator><creator>Cvijanovic, Olga</creator><creator>Maric, Ivana</creator><creator>Tomas, Maja Ilic</creator><creator>Jurisic-Erzen, Dubravka</creator><creator>Licul, Vanja</creator><creator>Bobinac, Dragica</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>How Activity of Inflammatory Bowel Disease Influences Bone Loss</title><author>Orlic, Zeljka Crncevic ; Turk, Tamara ; Sincic, Brankica Mijandrusic ; Stimac, Davor ; Cvijanovic, Olga ; Maric, Ivana ; Tomas, Maja Ilic ; Jurisic-Erzen, Dubravka ; Licul, Vanja ; Bobinac, Dragica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-d7057b08f1128ea35fe69781d145c85fdf06f481bb591c2d1c0672f18ad2915f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Absorptiometry, Photon - methods</topic><topic>Adult</topic><topic>Aged</topic><topic>Bone Density</topic><topic>Bone Resorption - diagnostic imaging</topic><topic>Bone Resorption - etiology</topic><topic>Bone Resorption - metabolism</topic><topic>Corticosteroids</topic><topic>Disease Progression</topic><topic>duration and activity of disease</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Femur - diagnostic imaging</topic><topic>Femur - metabolism</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>IBD</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Inflammatory Bowel Diseases - metabolism</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>osteoporosis</topic><topic>Osteoporosis - diagnostic imaging</topic><topic>Osteoporosis - etiology</topic><topic>Osteoporosis - metabolism</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orlic, Zeljka Crncevic</creatorcontrib><creatorcontrib>Turk, Tamara</creatorcontrib><creatorcontrib>Sincic, Brankica Mijandrusic</creatorcontrib><creatorcontrib>Stimac, Davor</creatorcontrib><creatorcontrib>Cvijanovic, Olga</creatorcontrib><creatorcontrib>Maric, Ivana</creatorcontrib><creatorcontrib>Tomas, Maja Ilic</creatorcontrib><creatorcontrib>Jurisic-Erzen, Dubravka</creatorcontrib><creatorcontrib>Licul, Vanja</creatorcontrib><creatorcontrib>Bobinac, Dragica</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical densitometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orlic, Zeljka Crncevic</au><au>Turk, Tamara</au><au>Sincic, Brankica Mijandrusic</au><au>Stimac, Davor</au><au>Cvijanovic, Olga</au><au>Maric, Ivana</au><au>Tomas, Maja Ilic</au><au>Jurisic-Erzen, Dubravka</au><au>Licul, Vanja</au><au>Bobinac, Dragica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How Activity of Inflammatory Bowel Disease Influences Bone Loss</atitle><jtitle>Journal of clinical densitometry</jtitle><addtitle>J Clin Densitom</addtitle><date>2010</date><risdate>2010</risdate><volume>13</volume><issue>1</issue><spage>36</spage><epage>42</epage><pages>36-42</pages><issn>1094-6950</issn><eissn>1559-0747</eissn><abstract>Abstract Bone loss is a common problem for individuals with inflammatory bowel disease (IBD). The aim of our study was to assess bone mineral density (BMD) in patients with IBD and to investigate the role of corticosteroid (CS) use and duration and activity of disease on BMD. Ninety-two patients (56 men and 36 women) with IBD, of whom 32 had ulcerative colitis (UC) and 60 had Crohn's disease (CD), underwent clinical assessment. Lumbar and femoral neck BMDs were measured by dual-energy X-ray absorptiometry. Osteopenia was observed in 14 patients (43%) with UC and in 24 patients (40%) with CD ( p = 0.187). Four patients (12%) with UC and 7 patients (11%) with CD had osteoporosis ( p = 0.308). Femoral BMD decreased in patients with long duration of CS use and correlated inversely with disease activity. Multiple regression analysis of BMD showed that statistically significant risk factors were duration of active disease and body mass index as well. Based on our results, it is necessary to take into account the risk of decreased BMD in patients with IBD. It is most important to achieve disease remission as soon as possible in addition to nutritional support.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20171567</pmid><doi>10.1016/j.jocd.2009.12.002</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1094-6950 |
| ispartof | Journal of clinical densitometry, 2010, Vol.13 (1), p.36-42 |
| issn | 1094-6950 1559-0747 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733808191 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Absorptiometry, Photon - methods Adult Aged Bone Density Bone Resorption - diagnostic imaging Bone Resorption - etiology Bone Resorption - metabolism Corticosteroids Disease Progression duration and activity of disease Endocrinology & Metabolism Female Femur - diagnostic imaging Femur - metabolism Follow-Up Studies Humans IBD Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - metabolism Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - metabolism Male Middle Aged osteoporosis Osteoporosis - diagnostic imaging Osteoporosis - etiology Osteoporosis - metabolism Prognosis Retrospective Studies Time Factors Young Adult |
| title | How Activity of Inflammatory Bowel Disease Influences Bone Loss |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T16%3A46%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=How%20Activity%20of%20Inflammatory%20Bowel%20Disease%20Influences%20Bone%20Loss&rft.jtitle=Journal%20of%20clinical%20densitometry&rft.au=Orlic,%20Zeljka%20Crncevic&rft.date=2010&rft.volume=13&rft.issue=1&rft.spage=36&rft.epage=42&rft.pages=36-42&rft.issn=1094-6950&rft.eissn=1559-0747&rft_id=info:doi/10.1016/j.jocd.2009.12.002&rft_dat=%3Cproquest_cross%3E733808191%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733808191&rft_id=info:pmid/20171567&rft_els_id=S1094695009002716&rfr_iscdi=true |