Efficacy of Oral Sucrose in Infants of Methadone-Maintained Mothers
Background: One report indicated that taste-induced analgesia was sub-optimal in methadone-exposed (ME) infants. Objectives: The purpose of this work was to compare the effects of oral sucrose in infants born to methadone-maintained mothers with control infants. Methods: The aim was to compare the e...
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| Veröffentlicht in: | Neonatology (Basel, Switzerland) Switzerland), 2010-01, Vol.97 (1), p.67-70 |
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| creator | Marceau, James R. Murray, Henry Nanan, Ralph K.H. |
| description | Background: One report indicated that taste-induced analgesia was sub-optimal in methadone-exposed (ME) infants. Objectives: The purpose of this work was to compare the effects of oral sucrose in infants born to methadone-maintained mothers with control infants. Methods: The aim was to compare the effects of an oral sucrose solution in infants scheduled to have a heel lance procedure for routine newborn screening. Infants received 0.05 ml (one drop) of a 24% sucrose solution by mouth 2 min before a heel lance procedure, then a further 0.05 ml of sucrose at the time of the heel lance; this was repeated every 1–2 min until 30 s after the completion of the procedure. The primary outcome measure was pain. We assessed pain using the Premature Infant Pain Profile (PIPP), which is a validated composite pain assessment tool. Results: PIPP scores were similar in both infant groups. Median PIPP scores of the ME infant group versus the control infant group were 2.0 (interquartile range (IQR) 0–7) versus 2.0 (IQR 0–9) at the time of the heel lance (p = 0.99) and 2.0 (IQR 0–4) versus 1.0 (IQR 0–4) 30 s after the completion of the heel lance procedure (p = 0.28). Conclusions: This study found no differences in the pain responses of ME infants and non-exposed infants when given sucrose during heel lance procedures. |
| doi_str_mv | 10.1159/000231519 |
| format | Article |
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Objectives: The purpose of this work was to compare the effects of oral sucrose in infants born to methadone-maintained mothers with control infants. Methods: The aim was to compare the effects of an oral sucrose solution in infants scheduled to have a heel lance procedure for routine newborn screening. Infants received 0.05 ml (one drop) of a 24% sucrose solution by mouth 2 min before a heel lance procedure, then a further 0.05 ml of sucrose at the time of the heel lance; this was repeated every 1–2 min until 30 s after the completion of the procedure. The primary outcome measure was pain. We assessed pain using the Premature Infant Pain Profile (PIPP), which is a validated composite pain assessment tool. Results: PIPP scores were similar in both infant groups. Median PIPP scores of the ME infant group versus the control infant group were 2.0 (interquartile range (IQR) 0–7) versus 2.0 (IQR 0–9) at the time of the heel lance (p = 0.99) and 2.0 (IQR 0–4) versus 1.0 (IQR 0–4) 30 s after the completion of the heel lance procedure (p = 0.28). Conclusions: This study found no differences in the pain responses of ME infants and non-exposed infants when given sucrose during heel lance procedures.</description><identifier>ISSN: 1661-7800</identifier><identifier>EISSN: 1661-7819</identifier><identifier>DOI: 10.1159/000231519</identifier><identifier>PMID: 19648774</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Administration, Oral ; Adult ; Analgesia - methods ; Analgesics - therapeutic use ; Blood Specimen Collection - adverse effects ; Female ; Gestational Age ; Heel - blood supply ; Heroin Dependence - drug therapy ; Humans ; Maternal-Fetal Exchange ; Methadone - adverse effects ; Narcotics - adverse effects ; Original Paper ; Pain - etiology ; Pain - physiopathology ; Pain - prevention & control ; Pain Measurement ; Pregnancy ; Prospective Studies ; Sucrose - therapeutic use ; Sweetening Agents - therapeutic use</subject><ispartof>Neonatology (Basel, Switzerland), 2010-01, Vol.97 (1), p.67-70</ispartof><rights>2009 S. Karger AG, Basel</rights><rights>Copyright 2009 S. Karger AG, Basel.</rights><rights>Copyright (c) 2009 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-56f02248dcc0ee66e2552ab68b202fab5d0e7eba62ff174818cbe340063126e53</citedby><cites>FETCH-LOGICAL-c332t-56f02248dcc0ee66e2552ab68b202fab5d0e7eba62ff174818cbe340063126e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19648774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marceau, James R.</creatorcontrib><creatorcontrib>Murray, Henry</creatorcontrib><creatorcontrib>Nanan, Ralph K.H.</creatorcontrib><title>Efficacy of Oral Sucrose in Infants of Methadone-Maintained Mothers</title><title>Neonatology (Basel, Switzerland)</title><addtitle>Neonatology</addtitle><description>Background: One report indicated that taste-induced analgesia was sub-optimal in methadone-exposed (ME) infants. Objectives: The purpose of this work was to compare the effects of oral sucrose in infants born to methadone-maintained mothers with control infants. Methods: The aim was to compare the effects of an oral sucrose solution in infants scheduled to have a heel lance procedure for routine newborn screening. Infants received 0.05 ml (one drop) of a 24% sucrose solution by mouth 2 min before a heel lance procedure, then a further 0.05 ml of sucrose at the time of the heel lance; this was repeated every 1–2 min until 30 s after the completion of the procedure. The primary outcome measure was pain. We assessed pain using the Premature Infant Pain Profile (PIPP), which is a validated composite pain assessment tool. Results: PIPP scores were similar in both infant groups. Median PIPP scores of the ME infant group versus the control infant group were 2.0 (interquartile range (IQR) 0–7) versus 2.0 (IQR 0–9) at the time of the heel lance (p = 0.99) and 2.0 (IQR 0–4) versus 1.0 (IQR 0–4) 30 s after the completion of the heel lance procedure (p = 0.28). Conclusions: This study found no differences in the pain responses of ME infants and non-exposed infants when given sucrose during heel lance procedures.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Analgesia - methods</subject><subject>Analgesics - therapeutic use</subject><subject>Blood Specimen Collection - adverse effects</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Heel - blood supply</subject><subject>Heroin Dependence - drug therapy</subject><subject>Humans</subject><subject>Maternal-Fetal Exchange</subject><subject>Methadone - adverse effects</subject><subject>Narcotics - adverse effects</subject><subject>Original Paper</subject><subject>Pain - etiology</subject><subject>Pain - physiopathology</subject><subject>Pain - prevention & control</subject><subject>Pain Measurement</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Sucrose - therapeutic use</subject><subject>Sweetening Agents - therapeutic use</subject><issn>1661-7800</issn><issn>1661-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0M9LwzAUB_AgipvTg3eR4kU8VF-S5kePMqYONnZQzyVNX1xn186kPey_t2NjgoeQQD7v8d6XkGsKj5SK9AkAGKeCpidkSKWksdI0PT2-AQbkIoQVgBBCsnMyoKlMtFLJkIwnzpXW2G3UuGjhTRW9d9Y3AaOyjqa1M3Ubdl9zbJemaGqM56as2_5gEc2bdok-XJIzZ6qAV4d7RD5fJh_jt3i2eJ2On2ex5Zy1sZAOGEt0YS0gSolMCGZyqXMGzJlcFIAKcyOZc1QlmmqbI08AJKdMouAjcr_vu_HNT4ehzdZlsFhVpsamC5niXIMCLXt590-ums7X_XAZY0wJljLVo4c92u0bPLps48u18duMQrbLNTvm2tvbQ8MuX2PxJw9B9uBmD76N_0J_BIf6X2kWeSc</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Marceau, James R.</creator><creator>Murray, Henry</creator><creator>Nanan, Ralph K.H.</creator><general>S. 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Murray, Henry ; Nanan, Ralph K.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-56f02248dcc0ee66e2552ab68b202fab5d0e7eba62ff174818cbe340063126e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Analgesia - methods</topic><topic>Analgesics - therapeutic use</topic><topic>Blood Specimen Collection - adverse effects</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Heel - blood supply</topic><topic>Heroin Dependence - drug therapy</topic><topic>Humans</topic><topic>Maternal-Fetal Exchange</topic><topic>Methadone - adverse effects</topic><topic>Narcotics - adverse effects</topic><topic>Original Paper</topic><topic>Pain - etiology</topic><topic>Pain - physiopathology</topic><topic>Pain - prevention & control</topic><topic>Pain Measurement</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Sucrose - therapeutic use</topic><topic>Sweetening Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marceau, James R.</creatorcontrib><creatorcontrib>Murray, Henry</creatorcontrib><creatorcontrib>Nanan, Ralph K.H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neonatology (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marceau, James R.</au><au>Murray, Henry</au><au>Nanan, Ralph K.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Oral Sucrose in Infants of Methadone-Maintained Mothers</atitle><jtitle>Neonatology (Basel, Switzerland)</jtitle><addtitle>Neonatology</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>97</volume><issue>1</issue><spage>67</spage><epage>70</epage><pages>67-70</pages><issn>1661-7800</issn><eissn>1661-7819</eissn><abstract>Background: One report indicated that taste-induced analgesia was sub-optimal in methadone-exposed (ME) infants. Objectives: The purpose of this work was to compare the effects of oral sucrose in infants born to methadone-maintained mothers with control infants. Methods: The aim was to compare the effects of an oral sucrose solution in infants scheduled to have a heel lance procedure for routine newborn screening. Infants received 0.05 ml (one drop) of a 24% sucrose solution by mouth 2 min before a heel lance procedure, then a further 0.05 ml of sucrose at the time of the heel lance; this was repeated every 1–2 min until 30 s after the completion of the procedure. The primary outcome measure was pain. We assessed pain using the Premature Infant Pain Profile (PIPP), which is a validated composite pain assessment tool. Results: PIPP scores were similar in both infant groups. Median PIPP scores of the ME infant group versus the control infant group were 2.0 (interquartile range (IQR) 0–7) versus 2.0 (IQR 0–9) at the time of the heel lance (p = 0.99) and 2.0 (IQR 0–4) versus 1.0 (IQR 0–4) 30 s after the completion of the heel lance procedure (p = 0.28). Conclusions: This study found no differences in the pain responses of ME infants and non-exposed infants when given sucrose during heel lance procedures.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>19648774</pmid><doi>10.1159/000231519</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neonatology (Basel, Switzerland), 2010-01, Vol.97 (1), p.67-70 |
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| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Administration, Oral Adult Analgesia - methods Analgesics - therapeutic use Blood Specimen Collection - adverse effects Female Gestational Age Heel - blood supply Heroin Dependence - drug therapy Humans Maternal-Fetal Exchange Methadone - adverse effects Narcotics - adverse effects Original Paper Pain - etiology Pain - physiopathology Pain - prevention & control Pain Measurement Pregnancy Prospective Studies Sucrose - therapeutic use Sweetening Agents - therapeutic use |
| title | Efficacy of Oral Sucrose in Infants of Methadone-Maintained Mothers |
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