Impact of ivermectin drug combinations on Pediculus humanus capitis infestation in primary schoolchildren of south Indian rural villages
Background Antifilarial drug combinations including ivermectin provide antifilarial activity with ancillary benefits on intestinal helminths and ectoparasites, such as chiggers and lice. The impact of single oral dose of antifilarial drugs, viz; (1) diethylcarbamazine (DEC) alone, (ii) DEC + albend...
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| Veröffentlicht in: | International journal of dermatology 2009-11, Vol.48 (11), p.1201-1205 |
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| creator | Munirathinam, Arumugam Sunish, Ittoop Pulikkottil Rajendran, Rathinasamy Tyagi, Brij Kishore |
| description | Background Antifilarial drug combinations including ivermectin provide antifilarial activity with ancillary benefits on intestinal helminths and ectoparasites, such as chiggers and lice. The impact of single oral dose of antifilarial drugs, viz; (1) diethylcarbamazine (DEC) alone, (ii) DEC + albendazole (ALB), (iii) ivermectin (IVR) + DEC and (iv) IVR + ALB, was determined, on the head louse (Pediculus humanus capitis) in primary school children in a rural community in south India.
Methods Primary school children (n = 534) of age 6–10 years from four villages of South India were examined for the presence of head lice before and after single dose of DEC + ivermectin drug combination. The effectiveness and the duration of cure sustained by these drugs were quantified. The head louse was examined by “combing method” during post‐treatment periods at 15, 45, 60 and 75 days interval.
Results The antifilarial drug consumption rate was similar (96–98%) in all treatment arms. In pre‐treatment survey the prevalence of head lice in children administered with DEC, DEC + ALB, IVR + DEC and IVR + ALB arm was 86%, 80%, 87% and 80%, respectively, with the latter two arms demonstrating significant reduction in louse infestation (P |
| doi_str_mv | 10.1111/j.1365-4632.2008.04059.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733806042</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733806042</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4679-8a129fc61b86b95f2dbd84335afd484e3878d43ed34eeb202aa44e70b2c83afb3</originalsourceid><addsrcrecordid>eNqNkc9y0zAQxjUMDE0Lr8DoApxs9M-ycuBAAzRhCvQAAzeNLMmNgi0FyW7TN-CxkZsQbgy67Gr29-3u7AcAxKjE-b3alJjyqmCckpIgJErEUDUvdw_A7Fh4CGYIYVzMc-UEnKa0yV9KMHsMTrKGM1zzGfi16rdKDzC00N3Y2Fs9OA9NHK-hDn3jvBpc8AkGD6-scXrsxgTXY698jlpt3eASdL61abgncw630fUq3sGk1yF0eu06E62fRqQwDmu48sYpD-MYVQdvXNepa5uegEet6pJ9eohn4Ov7d18Wy-Ly88Vq8eay0IzX80IoTOat5rgRvJlXLTGNEYzSSrWGCWapqIVh1BrKrG0IIkoxZmvUEC2oaht6Bl7u-25j-DnmtWXvkrZ5CW_DmGRNqUAcMZLJF_8kCSYME0wzKPagjiGlaFt5uIDESE5-yY2cbJGTLXLyS977JXdZ-uwwY2x6a47CPwZl4PkBUEmrro3Ka5f-cgTls1Qic6_33K3r7N1_LyBXH95OWdYXe71Lg90d9Sr-kLymdSW_fbqQS_69-ri4OpdL-hsuQMMN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21241213</pqid></control><display><type>article</type><title>Impact of ivermectin drug combinations on Pediculus humanus capitis infestation in primary schoolchildren of south Indian rural villages</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Munirathinam, Arumugam ; Sunish, Ittoop Pulikkottil ; Rajendran, Rathinasamy ; Tyagi, Brij Kishore</creator><creatorcontrib>Munirathinam, Arumugam ; Sunish, Ittoop Pulikkottil ; Rajendran, Rathinasamy ; Tyagi, Brij Kishore</creatorcontrib><description>Background Antifilarial drug combinations including ivermectin provide antifilarial activity with ancillary benefits on intestinal helminths and ectoparasites, such as chiggers and lice. The impact of single oral dose of antifilarial drugs, viz; (1) diethylcarbamazine (DEC) alone, (ii) DEC + albendazole (ALB), (iii) ivermectin (IVR) + DEC and (iv) IVR + ALB, was determined, on the head louse (Pediculus humanus capitis) in primary school children in a rural community in south India.
Methods Primary school children (n = 534) of age 6–10 years from four villages of South India were examined for the presence of head lice before and after single dose of DEC + ivermectin drug combination. The effectiveness and the duration of cure sustained by these drugs were quantified. The head louse was examined by “combing method” during post‐treatment periods at 15, 45, 60 and 75 days interval.
Results The antifilarial drug consumption rate was similar (96–98%) in all treatment arms. In pre‐treatment survey the prevalence of head lice in children administered with DEC, DEC + ALB, IVR + DEC and IVR + ALB arm was 86%, 80%, 87% and 80%, respectively, with the latter two arms demonstrating significant reduction in louse infestation (P < 0.05) for 60 days.
Conclusion Single dose with IVR combination demonstrates a greater impact in reducing head louse infestation in the endemic rural communities for nearly 60 days. Therefore, in regions such as Africa where ivermectin is part of the antifilariasis campaign, this drug will have an additional benefit in reducing head lice infestation.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/j.1365-4632.2008.04059.x</identifier><identifier>PMID: 20064176</identifier><identifier>CODEN: IJDEBB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Oral ; Albendazole - therapeutic use ; Animals ; Anthelmintics - therapeutic use ; Antiparasitic Agents - therapeutic use ; Biological and medical sciences ; Child ; Dermatology ; Diethylcarbamazine - therapeutic use ; Drug Therapy, Combination ; Endemic Diseases - statistics & numerical data ; Filaricides - therapeutic use ; General aspects ; Humans ; India ; Ivermectin - therapeutic use ; Lice Infestations - drug therapy ; Lice Infestations - epidemiology ; Lice Infestations - prevention & control ; Medical sciences ; Pediculus ; Pediculus humanus capitis ; Prevalence ; Rural Population - statistics & numerical data</subject><ispartof>International journal of dermatology, 2009-11, Vol.48 (11), p.1201-1205</ispartof><rights>2009 The International Society of Dermatology</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4679-8a129fc61b86b95f2dbd84335afd484e3878d43ed34eeb202aa44e70b2c83afb3</citedby><cites>FETCH-LOGICAL-c4679-8a129fc61b86b95f2dbd84335afd484e3878d43ed34eeb202aa44e70b2c83afb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-4632.2008.04059.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-4632.2008.04059.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22046758$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20064176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Munirathinam, Arumugam</creatorcontrib><creatorcontrib>Sunish, Ittoop Pulikkottil</creatorcontrib><creatorcontrib>Rajendran, Rathinasamy</creatorcontrib><creatorcontrib>Tyagi, Brij Kishore</creatorcontrib><title>Impact of ivermectin drug combinations on Pediculus humanus capitis infestation in primary schoolchildren of south Indian rural villages</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background Antifilarial drug combinations including ivermectin provide antifilarial activity with ancillary benefits on intestinal helminths and ectoparasites, such as chiggers and lice. The impact of single oral dose of antifilarial drugs, viz; (1) diethylcarbamazine (DEC) alone, (ii) DEC + albendazole (ALB), (iii) ivermectin (IVR) + DEC and (iv) IVR + ALB, was determined, on the head louse (Pediculus humanus capitis) in primary school children in a rural community in south India.
Methods Primary school children (n = 534) of age 6–10 years from four villages of South India were examined for the presence of head lice before and after single dose of DEC + ivermectin drug combination. The effectiveness and the duration of cure sustained by these drugs were quantified. The head louse was examined by “combing method” during post‐treatment periods at 15, 45, 60 and 75 days interval.
Results The antifilarial drug consumption rate was similar (96–98%) in all treatment arms. In pre‐treatment survey the prevalence of head lice in children administered with DEC, DEC + ALB, IVR + DEC and IVR + ALB arm was 86%, 80%, 87% and 80%, respectively, with the latter two arms demonstrating significant reduction in louse infestation (P < 0.05) for 60 days.
Conclusion Single dose with IVR combination demonstrates a greater impact in reducing head louse infestation in the endemic rural communities for nearly 60 days. Therefore, in regions such as Africa where ivermectin is part of the antifilariasis campaign, this drug will have an additional benefit in reducing head lice infestation.</description><subject>Administration, Oral</subject><subject>Albendazole - therapeutic use</subject><subject>Animals</subject><subject>Anthelmintics - therapeutic use</subject><subject>Antiparasitic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Dermatology</subject><subject>Diethylcarbamazine - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Endemic Diseases - statistics & numerical data</subject><subject>Filaricides - therapeutic use</subject><subject>General aspects</subject><subject>Humans</subject><subject>India</subject><subject>Ivermectin - therapeutic use</subject><subject>Lice Infestations - drug therapy</subject><subject>Lice Infestations - epidemiology</subject><subject>Lice Infestations - prevention & control</subject><subject>Medical sciences</subject><subject>Pediculus</subject><subject>Pediculus humanus capitis</subject><subject>Prevalence</subject><subject>Rural Population - statistics & numerical data</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9y0zAQxjUMDE0Lr8DoApxs9M-ycuBAAzRhCvQAAzeNLMmNgi0FyW7TN-CxkZsQbgy67Gr29-3u7AcAxKjE-b3alJjyqmCckpIgJErEUDUvdw_A7Fh4CGYIYVzMc-UEnKa0yV9KMHsMTrKGM1zzGfi16rdKDzC00N3Y2Fs9OA9NHK-hDn3jvBpc8AkGD6-scXrsxgTXY698jlpt3eASdL61abgncw630fUq3sGk1yF0eu06E62fRqQwDmu48sYpD-MYVQdvXNepa5uegEet6pJ9eohn4Ov7d18Wy-Ly88Vq8eay0IzX80IoTOat5rgRvJlXLTGNEYzSSrWGCWapqIVh1BrKrG0IIkoxZmvUEC2oaht6Bl7u-25j-DnmtWXvkrZ5CW_DmGRNqUAcMZLJF_8kCSYME0wzKPagjiGlaFt5uIDESE5-yY2cbJGTLXLyS977JXdZ-uwwY2x6a47CPwZl4PkBUEmrro3Ka5f-cgTls1Qic6_33K3r7N1_LyBXH95OWdYXe71Lg90d9Sr-kLymdSW_fbqQS_69-ri4OpdL-hsuQMMN</recordid><startdate>200911</startdate><enddate>200911</enddate><creator>Munirathinam, Arumugam</creator><creator>Sunish, Ittoop Pulikkottil</creator><creator>Rajendran, Rathinasamy</creator><creator>Tyagi, Brij Kishore</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>200911</creationdate><title>Impact of ivermectin drug combinations on Pediculus humanus capitis infestation in primary schoolchildren of south Indian rural villages</title><author>Munirathinam, Arumugam ; Sunish, Ittoop Pulikkottil ; Rajendran, Rathinasamy ; Tyagi, Brij Kishore</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4679-8a129fc61b86b95f2dbd84335afd484e3878d43ed34eeb202aa44e70b2c83afb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Administration, Oral</topic><topic>Albendazole - therapeutic use</topic><topic>Animals</topic><topic>Anthelmintics - therapeutic use</topic><topic>Antiparasitic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Dermatology</topic><topic>Diethylcarbamazine - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Endemic Diseases - statistics & numerical data</topic><topic>Filaricides - therapeutic use</topic><topic>General aspects</topic><topic>Humans</topic><topic>India</topic><topic>Ivermectin - therapeutic use</topic><topic>Lice Infestations - drug therapy</topic><topic>Lice Infestations - epidemiology</topic><topic>Lice Infestations - prevention & control</topic><topic>Medical sciences</topic><topic>Pediculus</topic><topic>Pediculus humanus capitis</topic><topic>Prevalence</topic><topic>Rural Population - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Munirathinam, Arumugam</creatorcontrib><creatorcontrib>Sunish, Ittoop Pulikkottil</creatorcontrib><creatorcontrib>Rajendran, Rathinasamy</creatorcontrib><creatorcontrib>Tyagi, Brij Kishore</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Munirathinam, Arumugam</au><au>Sunish, Ittoop Pulikkottil</au><au>Rajendran, Rathinasamy</au><au>Tyagi, Brij Kishore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of ivermectin drug combinations on Pediculus humanus capitis infestation in primary schoolchildren of south Indian rural villages</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2009-11</date><risdate>2009</risdate><volume>48</volume><issue>11</issue><spage>1201</spage><epage>1205</epage><pages>1201-1205</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><coden>IJDEBB</coden><abstract>Background Antifilarial drug combinations including ivermectin provide antifilarial activity with ancillary benefits on intestinal helminths and ectoparasites, such as chiggers and lice. The impact of single oral dose of antifilarial drugs, viz; (1) diethylcarbamazine (DEC) alone, (ii) DEC + albendazole (ALB), (iii) ivermectin (IVR) + DEC and (iv) IVR + ALB, was determined, on the head louse (Pediculus humanus capitis) in primary school children in a rural community in south India.
Methods Primary school children (n = 534) of age 6–10 years from four villages of South India were examined for the presence of head lice before and after single dose of DEC + ivermectin drug combination. The effectiveness and the duration of cure sustained by these drugs were quantified. The head louse was examined by “combing method” during post‐treatment periods at 15, 45, 60 and 75 days interval.
Results The antifilarial drug consumption rate was similar (96–98%) in all treatment arms. In pre‐treatment survey the prevalence of head lice in children administered with DEC, DEC + ALB, IVR + DEC and IVR + ALB arm was 86%, 80%, 87% and 80%, respectively, with the latter two arms demonstrating significant reduction in louse infestation (P < 0.05) for 60 days.
Conclusion Single dose with IVR combination demonstrates a greater impact in reducing head louse infestation in the endemic rural communities for nearly 60 days. Therefore, in regions such as Africa where ivermectin is part of the antifilariasis campaign, this drug will have an additional benefit in reducing head lice infestation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20064176</pmid><doi>10.1111/j.1365-4632.2008.04059.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | International journal of dermatology, 2009-11, Vol.48 (11), p.1201-1205 |
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| subjects | Administration, Oral Albendazole - therapeutic use Animals Anthelmintics - therapeutic use Antiparasitic Agents - therapeutic use Biological and medical sciences Child Dermatology Diethylcarbamazine - therapeutic use Drug Therapy, Combination Endemic Diseases - statistics & numerical data Filaricides - therapeutic use General aspects Humans India Ivermectin - therapeutic use Lice Infestations - drug therapy Lice Infestations - epidemiology Lice Infestations - prevention & control Medical sciences Pediculus Pediculus humanus capitis Prevalence Rural Population - statistics & numerical data |
| title | Impact of ivermectin drug combinations on Pediculus humanus capitis infestation in primary schoolchildren of south Indian rural villages |
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