Impact of the Enfuvirtide Resistance Mutation N43D and the Associated Baseline Polymorphism E137K on Peptide Sensitivity and Six-Helix Bundle Structure

Enfuvirtide (ENF), the first human immunodeficiency virus type 1 (HIV-1) fusion inhibitor approved for clinical use, acts by binding to gp41 heptad repeat 1 (HR1) and preventing its interaction with the viral HR2 region. Treatment-emergent resistance to ENF has been mapped to residues within HR1, an...

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Veröffentlicht in:	Biochemistry (Easton) 2008-06, Vol.47 (25), p.6662-6670
Hauptverfasser:	Bai, Xuefang, Wilson, Karen L, Seedorff, Jennifer E, Ahrens, Douglas, Green, Justin, Davison, Donna K, Jin, Lei, Stanfield-Oakley, Sherry A, Mosier, Sarah M, Melby, Thomas E, Cammack, Nick, Wang, Zhongmin, Greenberg, Michael L, Dwyer, John J
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Circular Dichroism Crystallography, X-Ray Drug Resistance, Viral - genetics HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - genetics HIV Envelope Protein gp41 - pharmacology HIV Fusion Inhibitors - pharmacology HIV-1 - drug effects HIV-1 - genetics Humans Hydrogen Bonding Inhibitory Concentration 50 Models, Molecular Mutation Peptide Fragments - pharmacology Polymorphism, Genetic Protein Structure, Secondary Protein Structure, Tertiary
Online-Zugang:	Volltext
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