Familial Chronic Lymphocytic Leukemia in Norway and Denmark. Comments on Pleiotropy and Birth Order
Aim: To investigate the genetics of chronic lymphocytic leukemia (CLL). Materials and Methods: In 56 (7%) out of 800 CLL patients with concomitant malignant hematological disease, 51 families and 141 cases were ascertained. Result: 106 cases (75%) of CLL, 27 cases (19%) of nonCLL and 8 cases (6%) of...
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| Veröffentlicht in: | In vivo (Athens) 2010-01, Vol.24 (1), p.85-95 |
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| creator | Jønsson, Viggo Tjønnfjord, Geir E Johannesen, Tom B Ly, Bernt Olsen, Jørgen H Yuille, Martin |
| description | Aim: To investigate the genetics of chronic lymphocytic leukemia (CLL). Materials and Methods: In 56 (7%) out of 800 CLL patients
with concomitant malignant hematological disease, 51 families and 141 cases were ascertained. Result: 106 cases (75%) of CLL,
27 cases (19%) of nonCLL and 8 cases (6%) of myeloproliferative disorders. Paternal disease was transmitted primarily to the
youngest sons in the sibship while maternal disease was transmitted equally to all sibs, demonstrated by means of matrix conjugation
and confirmed with Cox regression on parity and birth order (maternal-offspring combination: relative risk (RR), 95% confidence
interval (CI)=1.47 (0.89 - 2.43), p=0.12, compared with paternal-offspring combination: RR=3.25, 95% CI=(1.57-6.72), p |
| format | Article |
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with concomitant malignant hematological disease, 51 families and 141 cases were ascertained. Result: 106 cases (75%) of CLL,
27 cases (19%) of nonCLL and 8 cases (6%) of myeloproliferative disorders. Paternal disease was transmitted primarily to the
youngest sons in the sibship while maternal disease was transmitted equally to all sibs, demonstrated by means of matrix conjugation
and confirmed with Cox regression on parity and birth order (maternal-offspring combination: relative risk (RR), 95% confidence
interval (CI)=1.47 (0.89 - 2.43), p=0.12, compared with paternal-offspring combination: RR=3.25, 95% CI=(1.57-6.72), p<0.001).
The B-cell expression in familial and sporadic CLL was indistinguishable. Conclusion: Parental genomic imprinting is pointed
out as one possible mechanism behind this non-Mendelian genomic output.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>PMID: 20133982</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Birth Order ; Cohort Studies ; Denmark - epidemiology ; Family Health ; Fathers ; Female ; Genetic Predisposition to Disease ; Genomic Imprinting ; Humans ; Inheritance Patterns ; Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell - genetics ; Male ; Mothers ; Myeloproliferative Disorders - epidemiology ; Myeloproliferative Disorders - genetics ; Norway - epidemiology ; Pedigree ; Polymorphism, Genetic ; Risk</subject><ispartof>In vivo (Athens), 2010-01, Vol.24 (1), p.85-95</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20133982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jønsson, Viggo</creatorcontrib><creatorcontrib>Tjønnfjord, Geir E</creatorcontrib><creatorcontrib>Johannesen, Tom B</creatorcontrib><creatorcontrib>Ly, Bernt</creatorcontrib><creatorcontrib>Olsen, Jørgen H</creatorcontrib><creatorcontrib>Yuille, Martin</creatorcontrib><title>Familial Chronic Lymphocytic Leukemia in Norway and Denmark. Comments on Pleiotropy and Birth Order</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>Aim: To investigate the genetics of chronic lymphocytic leukemia (CLL). Materials and Methods: In 56 (7%) out of 800 CLL patients
with concomitant malignant hematological disease, 51 families and 141 cases were ascertained. Result: 106 cases (75%) of CLL,
27 cases (19%) of nonCLL and 8 cases (6%) of myeloproliferative disorders. Paternal disease was transmitted primarily to the
youngest sons in the sibship while maternal disease was transmitted equally to all sibs, demonstrated by means of matrix conjugation
and confirmed with Cox regression on parity and birth order (maternal-offspring combination: relative risk (RR), 95% confidence
interval (CI)=1.47 (0.89 - 2.43), p=0.12, compared with paternal-offspring combination: RR=3.25, 95% CI=(1.57-6.72), p<0.001).
The B-cell expression in familial and sporadic CLL was indistinguishable. Conclusion: Parental genomic imprinting is pointed
out as one possible mechanism behind this non-Mendelian genomic output.</description><subject>Birth Order</subject><subject>Cohort Studies</subject><subject>Denmark - epidemiology</subject><subject>Family Health</subject><subject>Fathers</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genomic Imprinting</subject><subject>Humans</subject><subject>Inheritance Patterns</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</subject><subject>Male</subject><subject>Mothers</subject><subject>Myeloproliferative Disorders - epidemiology</subject><subject>Myeloproliferative Disorders - genetics</subject><subject>Norway - epidemiology</subject><subject>Pedigree</subject><subject>Polymorphism, Genetic</subject><subject>Risk</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10F1LwzAUBuAgipvTvyABL7yq5KNp0kutToXhvFDwLmRtauOSpiato__eyubVObw8HHjPEZhjnuOEszQ_BnNEmEgEwx8zcBbjF0IZR4icghlBmNJckDkol8oZa5SFRRN8a0q4Gl3X-HLs_3Y9bLUzCpoWvviwUyNUbQXvdetU2N7Awjun2z5C38JXq43vg-_25s6EvoHrUOlwDk5qZaO-OMwFeF8-vBVPyWr9-FzcrpKGUNEnteAiVYpmpeB8k2pCtFYKbRSrKM0EQ4xjRvNU1UyLUvGUsynEvBZVWmY5oQtwvb_bBf896NhLZ2KprVWt9kOUnFKBKMJikpcHOWycrmQXzFRolP9_mcDVHjTms9mZoGV0ytqJU2l-SCqxFIz-AvZLa8o</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Jønsson, Viggo</creator><creator>Tjønnfjord, Geir E</creator><creator>Johannesen, Tom B</creator><creator>Ly, Bernt</creator><creator>Olsen, Jørgen H</creator><creator>Yuille, Martin</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Familial Chronic Lymphocytic Leukemia in Norway and Denmark. Comments on Pleiotropy and Birth Order</title><author>Jønsson, Viggo ; Tjønnfjord, Geir E ; Johannesen, Tom B ; Ly, Bernt ; Olsen, Jørgen H ; Yuille, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-f8784aa36c877b4e22eeaa0ba5d3368505715394af5e8ca747585017f8d4c6923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Birth Order</topic><topic>Cohort Studies</topic><topic>Denmark - epidemiology</topic><topic>Family Health</topic><topic>Fathers</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genomic Imprinting</topic><topic>Humans</topic><topic>Inheritance Patterns</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</topic><topic>Male</topic><topic>Mothers</topic><topic>Myeloproliferative Disorders - epidemiology</topic><topic>Myeloproliferative Disorders - genetics</topic><topic>Norway - epidemiology</topic><topic>Pedigree</topic><topic>Polymorphism, Genetic</topic><topic>Risk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jønsson, Viggo</creatorcontrib><creatorcontrib>Tjønnfjord, Geir E</creatorcontrib><creatorcontrib>Johannesen, Tom B</creatorcontrib><creatorcontrib>Ly, Bernt</creatorcontrib><creatorcontrib>Olsen, Jørgen H</creatorcontrib><creatorcontrib>Yuille, Martin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jønsson, Viggo</au><au>Tjønnfjord, Geir E</au><au>Johannesen, Tom B</au><au>Ly, Bernt</au><au>Olsen, Jørgen H</au><au>Yuille, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Familial Chronic Lymphocytic Leukemia in Norway and Denmark. Comments on Pleiotropy and Birth Order</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>24</volume><issue>1</issue><spage>85</spage><epage>95</epage><pages>85-95</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>Aim: To investigate the genetics of chronic lymphocytic leukemia (CLL). Materials and Methods: In 56 (7%) out of 800 CLL patients
with concomitant malignant hematological disease, 51 families and 141 cases were ascertained. Result: 106 cases (75%) of CLL,
27 cases (19%) of nonCLL and 8 cases (6%) of myeloproliferative disorders. Paternal disease was transmitted primarily to the
youngest sons in the sibship while maternal disease was transmitted equally to all sibs, demonstrated by means of matrix conjugation
and confirmed with Cox regression on parity and birth order (maternal-offspring combination: relative risk (RR), 95% confidence
interval (CI)=1.47 (0.89 - 2.43), p=0.12, compared with paternal-offspring combination: RR=3.25, 95% CI=(1.57-6.72), p<0.001).
The B-cell expression in familial and sporadic CLL was indistinguishable. Conclusion: Parental genomic imprinting is pointed
out as one possible mechanism behind this non-Mendelian genomic output.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>20133982</pmid><tpages>11</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Birth Order Cohort Studies Denmark - epidemiology Family Health Fathers Female Genetic Predisposition to Disease Genomic Imprinting Humans Inheritance Patterns Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Male Mothers Myeloproliferative Disorders - epidemiology Myeloproliferative Disorders - genetics Norway - epidemiology Pedigree Polymorphism, Genetic Risk |
| title | Familial Chronic Lymphocytic Leukemia in Norway and Denmark. Comments on Pleiotropy and Birth Order |
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