Pathways by Which Reconstituted High-Density Lipoprotein Mobilizes Free Cholesterol From Whole Body and From Macrophages

OBJECTIVE—Reconstituted high-density lipoprotein (rHDL) is of interest as a potential novel therapy for atherosclerosis because of its ability to promote free cholesterol (FC) mobilization after intravenous administration. We performed studies to identify the underlying molecular mechanisms by which...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2010-03, Vol.30 (3), p.526-532
Hauptverfasser:	Cuchel, Marina, Lund-Katz, Sissel, de la Llera-Moya, Margarita, Millar, John S, Chang, David, Fuki, Ilia, Rothblat, George H, Phillips, Michael C, Rader, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis (general aspects, experimental research) ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Sub-Family G, Member 1 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Blood and lymphatic vessels Blood coagulation. Blood cells Cardiology. Vascular system Cells, Cultured Cholesterol - metabolism Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fundamental and applied biological sciences. Psychology Injections, Intravenous Lipoproteins - genetics Lipoproteins - metabolism Lipoproteins, HDL - administration & dosage Lipoproteins, HDL - pharmacology Macrophages - cytology Macrophages - metabolism Medical sciences Mice Mice, Knockout Models, Animal Molecular and cellular biology Platelet Scavenger Receptors, Class B - genetics Scavenger Receptors, Class B - metabolism Signal Transduction - physiology
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