Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth–inhibitory activity

The retinoid 4-oxo- N -(4-hydroxyphenyl)retinamide (4-oxo-4-HPR), a metabolite of fenretinide (4-HPR) present in plasma of 4-HPR–treated patients, is very effective in inducing growth inhibition and apoptosis in several cancer cell lines. 4-Oxo-4-HPR and 4-HPR have different mechanisms of action bec...

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Veröffentlicht in:	Molecular cancer therapeutics 2009-12, Vol.8 (12), p.3360-3368
Hauptverfasser:	Appierto, Valentina, Tiberio, Paola, Cavadini, Elena, Casalini, Patrizia, Cappelletti, Graziella, Formelli, Franca
Format:	Artikel
Sprache:	eng
Schlagworte:	4-oxo-fenretinide Actins - genetics Antimitotic Agents - pharmacology Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Cycle - drug effects Cell Line, Tumor Female Fenretinide - analogs & derivatives Fenretinide - pharmacology Gene Expression Regulation, Neoplastic - drug effects Growth Inhibitors - pharmacology Humans Kinesin - genetics Microfilament Proteins - genetics Microscopy, Fluorescence Microtubule-Associated Proteins - genetics Microtubules - drug effects Microtubules - metabolism mitosis Mitotic Index Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Polymers - metabolism retinoids Retinoids - pharmacology Reverse Transcriptase Polymerase Chain Reaction spindle Spindle Apparatus - drug effects Tankyrases - genetics tubulin Tubulin - metabolism
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