Childhood peripheral neuropathy with autoantibodies to myelin glycoprotein P0
The serum of a 4-year-old child with severe hypertrophic peripheral neuropathy contained high-titer polyclonal antibodies, mainly of IgG class, reacting with the 30-kd P0 glycoprotein of peripheral nerve. This was demonstrated by indirect immunofluorescence, immunoblot analysis of myelin proteins, a...
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| Veröffentlicht in: | Annals of neurology 1992-11, Vol.32 (5), p.700-702 |
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| container_title | Annals of neurology |
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| creator | Ben Jelloun-Dellagi, S Dellagi, K Burger, D Ben Younes-Chennoufi, A Hentati, F F Steck, A Ben Hamida, M |
| description | The serum of a 4-year-old child with severe hypertrophic peripheral neuropathy contained high-titer polyclonal antibodies, mainly of IgG class, reacting with the 30-kd P0 glycoprotein of peripheral nerve. This was demonstrated by indirect immunofluorescence, immunoblot analysis of myelin proteins, and enzyme-linked immunosorbent assay with purified P0 glycoprotein. The antibodies did not react with myelin-associated glycoprotein, sulfated glycuronic acid-containing paragloboside (SGPG and SGLPG), or other peripheral nerve glycolipids or gangliosides. To our knowledge this is the first report of strong antibody activity specifically directed against P0. This antibody may play a causative role in the pathogenesis of the peripheral neuropathy in this patient. |
| format | Article |
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This was demonstrated by indirect immunofluorescence, immunoblot analysis of myelin proteins, and enzyme-linked immunosorbent assay with purified P0 glycoprotein. The antibodies did not react with myelin-associated glycoprotein, sulfated glycuronic acid-containing paragloboside (SGPG and SGLPG), or other peripheral nerve glycolipids or gangliosides. To our knowledge this is the first report of strong antibody activity specifically directed against P0. This antibody may play a causative role in the pathogenesis of the peripheral neuropathy in this patient.</description><identifier>ISSN: 0364-5134</identifier><identifier>PMID: 1280408</identifier><language>eng</language><publisher>United States</publisher><subject>Autoantibodies - analysis ; Cell Adhesion Molecules, Neuronal - immunology ; Child, Preschool ; Demyelinating Diseases - immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Fluorescent Antibody Technique ; Humans ; Immunoglobulin G - immunology ; Immunoglobulin M - immunology ; Myelin P0 Protein ; Myelin Proteins - immunology</subject><ispartof>Annals of neurology, 1992-11, Vol.32 (5), p.700-702</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1280408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ben Jelloun-Dellagi, S</creatorcontrib><creatorcontrib>Dellagi, K</creatorcontrib><creatorcontrib>Burger, D</creatorcontrib><creatorcontrib>Ben Younes-Chennoufi, A</creatorcontrib><creatorcontrib>Hentati, F F</creatorcontrib><creatorcontrib>Steck, A</creatorcontrib><creatorcontrib>Ben Hamida, M</creatorcontrib><title>Childhood peripheral neuropathy with autoantibodies to myelin glycoprotein P0</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>The serum of a 4-year-old child with severe hypertrophic peripheral neuropathy contained high-titer polyclonal antibodies, mainly of IgG class, reacting with the 30-kd P0 glycoprotein of peripheral nerve. This was demonstrated by indirect immunofluorescence, immunoblot analysis of myelin proteins, and enzyme-linked immunosorbent assay with purified P0 glycoprotein. The antibodies did not react with myelin-associated glycoprotein, sulfated glycuronic acid-containing paragloboside (SGPG and SGLPG), or other peripheral nerve glycolipids or gangliosides. To our knowledge this is the first report of strong antibody activity specifically directed against P0. This antibody may play a causative role in the pathogenesis of the peripheral neuropathy in this patient.</description><subject>Autoantibodies - analysis</subject><subject>Cell Adhesion Molecules, Neuronal - immunology</subject><subject>Child, Preschool</subject><subject>Demyelinating Diseases - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin M - immunology</subject><subject>Myelin P0 Protein</subject><subject>Myelin Proteins - immunology</subject><issn>0364-5134</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj01LxDAYhHNQ1nX1Jwg5eSuk--ajPUrxC3bRw95L2r6xkbSpSYr031uwcxkGHmaYK7JnIHkmcuA35DbGb8ZYKXO2I7v8WDDOij05V711Xe99RycMduoxaEdHnIOfdOoX-mtTT_WcvB6TbXxnMdLk6bCgsyP9ckvrp-ATruGT3ZFro13E-80P5PLyfKnestPH63v1dMomAUV2BNUxg6uMyLFFkKoRkoNgDXBmWuC5khKMaWXTrVBZiiY3jHOpAZQycCCP_7Xr8s-MMdWDjS06p0f0c6zVipVKyBV82MC5GbCrp2AHHZZ6uw9_kPxWwA</recordid><startdate>199211</startdate><enddate>199211</enddate><creator>Ben Jelloun-Dellagi, S</creator><creator>Dellagi, K</creator><creator>Burger, D</creator><creator>Ben Younes-Chennoufi, A</creator><creator>Hentati, F F</creator><creator>Steck, A</creator><creator>Ben Hamida, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199211</creationdate><title>Childhood peripheral neuropathy with autoantibodies to myelin glycoprotein P0</title><author>Ben Jelloun-Dellagi, S ; Dellagi, K ; Burger, D ; Ben Younes-Chennoufi, A ; Hentati, F F ; Steck, A ; Ben Hamida, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p538-237d0feeeef51ece367b564350b340fc3417663ffc6bdeef995b1f0446a3377f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Autoantibodies - analysis</topic><topic>Cell Adhesion Molecules, Neuronal - immunology</topic><topic>Child, Preschool</topic><topic>Demyelinating Diseases - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin M - immunology</topic><topic>Myelin P0 Protein</topic><topic>Myelin Proteins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ben Jelloun-Dellagi, S</creatorcontrib><creatorcontrib>Dellagi, K</creatorcontrib><creatorcontrib>Burger, D</creatorcontrib><creatorcontrib>Ben Younes-Chennoufi, A</creatorcontrib><creatorcontrib>Hentati, F F</creatorcontrib><creatorcontrib>Steck, A</creatorcontrib><creatorcontrib>Ben Hamida, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ben Jelloun-Dellagi, S</au><au>Dellagi, K</au><au>Burger, D</au><au>Ben Younes-Chennoufi, A</au><au>Hentati, F F</au><au>Steck, A</au><au>Ben Hamida, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Childhood peripheral neuropathy with autoantibodies to myelin glycoprotein P0</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1992-11</date><risdate>1992</risdate><volume>32</volume><issue>5</issue><spage>700</spage><epage>702</epage><pages>700-702</pages><issn>0364-5134</issn><abstract>The serum of a 4-year-old child with severe hypertrophic peripheral neuropathy contained high-titer polyclonal antibodies, mainly of IgG class, reacting with the 30-kd P0 glycoprotein of peripheral nerve. This was demonstrated by indirect immunofluorescence, immunoblot analysis of myelin proteins, and enzyme-linked immunosorbent assay with purified P0 glycoprotein. The antibodies did not react with myelin-associated glycoprotein, sulfated glycuronic acid-containing paragloboside (SGPG and SGLPG), or other peripheral nerve glycolipids or gangliosides. To our knowledge this is the first report of strong antibody activity specifically directed against P0. This antibody may play a causative role in the pathogenesis of the peripheral neuropathy in this patient.</abstract><cop>United States</cop><pmid>1280408</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Annals of neurology, 1992-11, Vol.32 (5), p.700-702 |
| issn | 0364-5134 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Autoantibodies - analysis Cell Adhesion Molecules, Neuronal - immunology Child, Preschool Demyelinating Diseases - immunology Enzyme-Linked Immunosorbent Assay Female Fluorescent Antibody Technique Humans Immunoglobulin G - immunology Immunoglobulin M - immunology Myelin P0 Protein Myelin Proteins - immunology |
| title | Childhood peripheral neuropathy with autoantibodies to myelin glycoprotein P0 |
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