Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes
In African traditional medicine, water decoction made from the dry seeds of Hunteria umbellata (K. Schum) Hallier f. is highly valued in the management of diabetes mellitus. In the present study, the antihyperglycaemic activity of the seed aqueous extract of Hunteria umbellate (K. Schum) Hallier f....
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| creator | Adeneye, Adejuwon Adewale Adeyemi, Olufunmilayo Olaide |
| description | In African traditional medicine, water decoction made from the dry seeds of
Hunteria umbellata (K. Schum) Hallier f. is highly valued in the management of diabetes mellitus.
In the present study, the antihyperglycaemic activity of the seed aqueous extract of
Hunteria umbellate (K. Schum) Hallier f. (
HU) was investigated in alloxan-induced, high fructose- and dexamethasone-induced hyperglycaemic rats.
Alloxan-induced, dexamethasone-induced and high fructose-induced hyperglycaemic rats were treated with single, daily oral administration of 1
mg/kg of glibenclamide, 50
mg/kg, 100
mg/kg and 200
mg/kg of
HU in Groups III, IV, V and VI, for 14 days, 21 days and 8 weeks, respectively. The effects of these drugs on FBG, free plasma insulin levels, HbA
1c, serum TG and TC, and insulin resistance indices were investigated.
Data generated in the current study showed that glibenclamide and graded oral doses of
HU caused significant dose related (
p
<
0.05, |
| doi_str_mv | 10.1016/j.jep.2009.08.037 |
| format | Article |
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Hunteria umbellata (K. Schum) Hallier f. is highly valued in the management of diabetes mellitus.
In the present study, the antihyperglycaemic activity of the seed aqueous extract of
Hunteria umbellate (K. Schum) Hallier f. (
HU) was investigated in alloxan-induced, high fructose- and dexamethasone-induced hyperglycaemic rats.
Alloxan-induced, dexamethasone-induced and high fructose-induced hyperglycaemic rats were treated with single, daily oral administration of 1
mg/kg of glibenclamide, 50
mg/kg, 100
mg/kg and 200
mg/kg of
HU in Groups III, IV, V and VI, for 14 days, 21 days and 8 weeks, respectively. The effects of these drugs on FBG, free plasma insulin levels, HbA
1c, serum TG and TC, and insulin resistance indices were investigated.
Data generated in the current study showed that glibenclamide and graded oral doses of
HU caused significant dose related (
p
<
0.05, <0.01 and <0.001) reductions in FBG when compared to the values obtained for the model control (Group II) rats. Similarly, daily oral administration of 66.7
g/kg fructose to rats for 8 weeks was associated with significant (
p
<
0.001) hyperglycaemia, elevations in plasma HbA
1c, free insulin, fasting insulin resistance indices, serum TG, and cholesterol. However, concomitant oral treatments with 1
mg/kg of glibenclamide, 50
mg/kg, 100
mg/kg, and 200
mg/kg of
HU extract significantly and dose dependently (
p
<
0.05, <0.01 and <0.001) attenuated development of hyperglycaemia, decreased levels of plasma HbA
1c, free insulin, and serum triglyceride and cholesterol, in the Groups III, IV, V and VI rats, respectively, when compared to fructose-induced hyperglycaemic (Group II) rats. Similar effect was also recorded in the dexamethasone-induced hyperglycaemic rats.
Results of this study suggest that the hypoglycaemic and antihyperlipidaemic effects of
HU are mediated via enhanced peripheral glucose uptake and improvements in hyperinsulinaemia.]]></description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2009.08.037</identifier><identifier>PMID: 19723575</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>animal models ; Animals ; Antihyperglycaemia ; Antihyperlipidaemia ; Apocynaceae ; Biological and medical sciences ; blood chemistry ; blood glucose ; Blood Glucose - metabolism ; cholesterol ; Cholesterol - blood ; diabetes mellitus ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes. Impaired glucose tolerance ; dosage ; dose response ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Experimental diabetes ; Fasting insulin indices ; fructose ; Fructose - administration & dosage ; Fructose - adverse effects ; General pharmacology ; Glyburide - administration & dosage ; Glyburide - pharmacology ; Glyburide - therapeutic use ; Glycated Hemoglobin A - metabolism ; glycemic effect ; hemoglobin ; Hunteria ; Hunteria umbellata ; Hunteria umbellata (K. Schum) Hallier f ; hyperglycemia ; Hyperglycemia - chemically induced ; Hyperglycemia - prevention & control ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; insulin ; Insulin - blood ; insulin resistance ; lipemic effect ; Male ; mechanism of action ; Medical sciences ; medicinal plants ; medicinal properties ; oral administration ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; plant extracts ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Random Allocation ; Rats ; Seeds ; triacylglycerols ; Triglycerides - blood</subject><ispartof>Journal of ethnopharmacology, 2009-11, Vol.126 (2), p.238-243</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-94c6acfc2e723792825c0996dc4927131cbbc1da591df9b8379c0e3a31b86cb53</citedby><cites>FETCH-LOGICAL-c406t-94c6acfc2e723792825c0996dc4927131cbbc1da591df9b8379c0e3a31b86cb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874109005327$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22154860$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19723575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adeneye, Adejuwon Adewale</creatorcontrib><creatorcontrib>Adeyemi, Olufunmilayo Olaide</creatorcontrib><title>Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description><![CDATA[In African traditional medicine, water decoction made from the dry seeds of
Hunteria umbellata (K. Schum) Hallier f. is highly valued in the management of diabetes mellitus.
In the present study, the antihyperglycaemic activity of the seed aqueous extract of
Hunteria umbellate (K. Schum) Hallier f. (
HU) was investigated in alloxan-induced, high fructose- and dexamethasone-induced hyperglycaemic rats.
Alloxan-induced, dexamethasone-induced and high fructose-induced hyperglycaemic rats were treated with single, daily oral administration of 1
mg/kg of glibenclamide, 50
mg/kg, 100
mg/kg and 200
mg/kg of
HU in Groups III, IV, V and VI, for 14 days, 21 days and 8 weeks, respectively. The effects of these drugs on FBG, free plasma insulin levels, HbA
1c, serum TG and TC, and insulin resistance indices were investigated.
Data generated in the current study showed that glibenclamide and graded oral doses of
HU caused significant dose related (
p
<
0.05, <0.01 and <0.001) reductions in FBG when compared to the values obtained for the model control (Group II) rats. Similarly, daily oral administration of 66.7
g/kg fructose to rats for 8 weeks was associated with significant (
p
<
0.001) hyperglycaemia, elevations in plasma HbA
1c, free insulin, fasting insulin resistance indices, serum TG, and cholesterol. However, concomitant oral treatments with 1
mg/kg of glibenclamide, 50
mg/kg, 100
mg/kg, and 200
mg/kg of
HU extract significantly and dose dependently (
p
<
0.05, <0.01 and <0.001) attenuated development of hyperglycaemia, decreased levels of plasma HbA
1c, free insulin, and serum triglyceride and cholesterol, in the Groups III, IV, V and VI rats, respectively, when compared to fructose-induced hyperglycaemic (Group II) rats. Similar effect was also recorded in the dexamethasone-induced hyperglycaemic rats.
Results of this study suggest that the hypoglycaemic and antihyperlipidaemic effects of
HU are mediated via enhanced peripheral glucose uptake and improvements in hyperinsulinaemia.]]></description><subject>animal models</subject><subject>Animals</subject><subject>Antihyperglycaemia</subject><subject>Antihyperlipidaemia</subject><subject>Apocynaceae</subject><subject>Biological and medical sciences</subject><subject>blood chemistry</subject><subject>blood glucose</subject><subject>Blood Glucose - metabolism</subject><subject>cholesterol</subject><subject>Cholesterol - blood</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>dosage</subject><subject>dose response</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Therapy, Combination</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Experimental diabetes</subject><subject>Fasting insulin indices</subject><subject>fructose</subject><subject>Fructose - administration & dosage</subject><subject>Fructose - adverse effects</subject><subject>General pharmacology</subject><subject>Glyburide - administration & dosage</subject><subject>Glyburide - pharmacology</subject><subject>Glyburide - therapeutic use</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>glycemic effect</subject><subject>hemoglobin</subject><subject>Hunteria</subject><subject>Hunteria umbellata</subject><subject>Hunteria umbellata (K. Schum) Hallier f</subject><subject>hyperglycemia</subject><subject>Hyperglycemia - chemically induced</subject><subject>Hyperglycemia - prevention & control</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>insulin</subject><subject>Insulin - blood</subject><subject>insulin resistance</subject><subject>lipemic effect</subject><subject>Male</subject><subject>mechanism of action</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>oral administration</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>plant extracts</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Seeds</subject><subject>triacylglycerols</subject><subject>Triglycerides - blood</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtv1DAUhS0EotPCD2AD3qDCYoLtPByLFaoog6jEonRt3dzcdDzKY7CdEbPmj-NoRrBj5cj5zvHRx9grKTIpZPVhl-1onykhTCbqTOT6CVvJWqu1LnX-lK3STb2udSEv2GUIOyGEloV4zi6k0Sovdbliv29nH7fkOR2gnyG6aeRTx2GMbnvck3_sjwg0OOSA0R1cPC6_N_MYyTvg89BQ30ME_u5bxu9xOw_v-Qb63qXKLuOBqOX0K_qU5m5Mn6nTDTRG6HnroKFI4QV71kEf6OX5vGIPt59_3GzWd9-_fL35dLfGQlRxbQqsADtUlMZro2pVojCmarEwSstcYtOgbKE0su1MUycGBeWQy6ausCnzK3Z96t376edMIdrBBVz2jzTNweo8RYpKLaQ8keinEDx1dp9Wgz9aKeyi3u5sUm8X9VbUNolOmdfn9rkZqP2XOLtOwNszAAGh7zyM6MJfTilZFnUlEvfmxHUwWXj0iXm4V0Lm6V2jpa4S8fFEULJ1SKptQEcjUus8YbTt5P4z9A8I3Kv2</recordid><startdate>20091112</startdate><enddate>20091112</enddate><creator>Adeneye, Adejuwon Adewale</creator><creator>Adeyemi, Olufunmilayo Olaide</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091112</creationdate><title>Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes</title><author>Adeneye, Adejuwon Adewale ; Adeyemi, Olufunmilayo Olaide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-94c6acfc2e723792825c0996dc4927131cbbc1da591df9b8379c0e3a31b86cb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>animal models</topic><topic>Animals</topic><topic>Antihyperglycaemia</topic><topic>Antihyperlipidaemia</topic><topic>Apocynaceae</topic><topic>Biological and medical sciences</topic><topic>blood chemistry</topic><topic>blood glucose</topic><topic>Blood Glucose - metabolism</topic><topic>cholesterol</topic><topic>Cholesterol - blood</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>dosage</topic><topic>dose response</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Therapy, Combination</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Experimental diabetes</topic><topic>Fasting insulin indices</topic><topic>fructose</topic><topic>Fructose - administration & dosage</topic><topic>Fructose - adverse effects</topic><topic>General pharmacology</topic><topic>Glyburide - administration & dosage</topic><topic>Glyburide - pharmacology</topic><topic>Glyburide - therapeutic use</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>glycemic effect</topic><topic>hemoglobin</topic><topic>Hunteria</topic><topic>Hunteria umbellata</topic><topic>Hunteria umbellata (K. Schum) Hallier f</topic><topic>hyperglycemia</topic><topic>Hyperglycemia - chemically induced</topic><topic>Hyperglycemia - prevention & control</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>insulin</topic><topic>Insulin - blood</topic><topic>insulin resistance</topic><topic>lipemic effect</topic><topic>Male</topic><topic>mechanism of action</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>oral administration</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>plant extracts</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Seeds</topic><topic>triacylglycerols</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adeneye, Adejuwon Adewale</creatorcontrib><creatorcontrib>Adeyemi, Olufunmilayo Olaide</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adeneye, Adejuwon Adewale</au><au>Adeyemi, Olufunmilayo Olaide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2009-11-12</date><risdate>2009</risdate><volume>126</volume><issue>2</issue><spage>238</spage><epage>243</epage><pages>238-243</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract><![CDATA[In African traditional medicine, water decoction made from the dry seeds of
Hunteria umbellata (K. Schum) Hallier f. is highly valued in the management of diabetes mellitus.
In the present study, the antihyperglycaemic activity of the seed aqueous extract of
Hunteria umbellate (K. Schum) Hallier f. (
HU) was investigated in alloxan-induced, high fructose- and dexamethasone-induced hyperglycaemic rats.
Alloxan-induced, dexamethasone-induced and high fructose-induced hyperglycaemic rats were treated with single, daily oral administration of 1
mg/kg of glibenclamide, 50
mg/kg, 100
mg/kg and 200
mg/kg of
HU in Groups III, IV, V and VI, for 14 days, 21 days and 8 weeks, respectively. The effects of these drugs on FBG, free plasma insulin levels, HbA
1c, serum TG and TC, and insulin resistance indices were investigated.
Data generated in the current study showed that glibenclamide and graded oral doses of
HU caused significant dose related (
p
<
0.05, <0.01 and <0.001) reductions in FBG when compared to the values obtained for the model control (Group II) rats. Similarly, daily oral administration of 66.7
g/kg fructose to rats for 8 weeks was associated with significant (
p
<
0.001) hyperglycaemia, elevations in plasma HbA
1c, free insulin, fasting insulin resistance indices, serum TG, and cholesterol. However, concomitant oral treatments with 1
mg/kg of glibenclamide, 50
mg/kg, 100
mg/kg, and 200
mg/kg of
HU extract significantly and dose dependently (
p
<
0.05, <0.01 and <0.001) attenuated development of hyperglycaemia, decreased levels of plasma HbA
1c, free insulin, and serum triglyceride and cholesterol, in the Groups III, IV, V and VI rats, respectively, when compared to fructose-induced hyperglycaemic (Group II) rats. Similar effect was also recorded in the dexamethasone-induced hyperglycaemic rats.
Results of this study suggest that the hypoglycaemic and antihyperlipidaemic effects of
HU are mediated via enhanced peripheral glucose uptake and improvements in hyperinsulinaemia.]]></abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19723575</pmid><doi>10.1016/j.jep.2009.08.037</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2009-11, Vol.126 (2), p.238-243 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733794625 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | animal models Animals Antihyperglycaemia Antihyperlipidaemia Apocynaceae Biological and medical sciences blood chemistry blood glucose Blood Glucose - metabolism cholesterol Cholesterol - blood diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes. Impaired glucose tolerance dosage dose response Dose-Response Relationship, Drug Drug Therapy, Combination Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Experimental diabetes Fasting insulin indices fructose Fructose - administration & dosage Fructose - adverse effects General pharmacology Glyburide - administration & dosage Glyburide - pharmacology Glyburide - therapeutic use Glycated Hemoglobin A - metabolism glycemic effect hemoglobin Hunteria Hunteria umbellata Hunteria umbellata (K. Schum) Hallier f hyperglycemia Hyperglycemia - chemically induced Hyperglycemia - prevention & control Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use insulin Insulin - blood insulin resistance lipemic effect Male mechanism of action Medical sciences medicinal plants medicinal properties oral administration Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy plant extracts Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Random Allocation Rats Seeds triacylglycerols Triglycerides - blood |
| title | Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes |
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