Bilateral destruction of neocortical and perirhinal projection targets of the acoustic thalamus does not disrupt auditory fear conditioning
The present study examined whether complete bilateral destruction of auditory cortex would interfere with auditory fear conditioning in rats. Complete destruction of auditory cortex required lesions of temporal neocortical and perirhinal periallocortical areas. Fear conditioning was assessed by meas...
Gespeichert in:
| Veröffentlicht in: | Neuroscience letters 1992-08, Vol.142 (2), p.228-232 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 232 |
|---|---|
| container_issue | 2 |
| container_start_page | 228 |
| container_title | Neuroscience letters |
| container_volume | 142 |
| creator | Romanski, Lizabeth M. LeDoux, Joseph E. |
| description | The present study examined whether complete bilateral destruction of auditory cortex would interfere with auditory fear conditioning in rats. Complete destruction of auditory cortex required lesions of temporal neocortical and perirhinal periallocortical areas. Fear conditioning was assessed by measuring freezing and arterial pressure responses elicited by an acoustic stimulus after pairing with footshock. Animals with complete bilateral lesions of auditory cortex showed conditioned arterial pressure and freezing responses comparable to those of unoperated controls. In contrast, bialteral destruction of the acoustic thalamus interfered with the conditioning of both responses. These results demonstrate that the auditory cortex is not required for the conditioning of fear responses to simple acoustic stimuli and add to the growing body of evidence that fear conditioning can be mediated by subcortical (amygdaloid) projections of the acoustic thalamus. |
| doi_str_mv | 10.1016/0304-3940(92)90379-L |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73379293</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>030439409290379L</els_id><sourcerecordid>16360619</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-aa85d4de2cfbdc770ce6689f252fc1c7997904ee0670f6af8afb79e4c37c8fb53</originalsourceid><addsrcrecordid>eNqFkcFuFSEUhonR1Gv1DTRhYRpdTAWGgWFjYptWm9zEja4JFw4tzVy4AmPSZ_ClZZybutMVOTnff-DwIfSaknNKqPhAesK7XnHyTrH3ivRSddsnaENHyTqpJHuKNo_Ic_SilHtCyEAHfoJOKB84Y3SDfl2EyVTIZsIOSs2zrSFFnDyOkGzKNdjWMtHhA-SQ70Js5SGne1jBavIt1LIE6h1gY9NcWqYVZjL7uWCXoOCYKnah5PlQsZldqCk_YA8mY5tiK9ukEG9fomfeTAVeHc9T9P366tvll2779fPN5adtZ7kYa2fMODjugFm_c1ZKYkGIUXk2MG-plUpJRTgAEZJ4Yfxo_E4q4LaXdvS7oT9FZ-vctsePuW2t96FYmCbTdp6Lln37S6b6_4JU9IIIqhrIV9DmVEoGrw857E1-0JToRZZeTOjFhFZM_5Glty325jh_3u3B_Q2tdlr_7bFvStPgs4k2lEds4FIwudz-ccWgfdrPAFkXGyBacCE3Tdql8O93_AYTR7TT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16360619</pqid></control><display><type>article</type><title>Bilateral destruction of neocortical and perirhinal projection targets of the acoustic thalamus does not disrupt auditory fear conditioning</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Romanski, Lizabeth M. ; LeDoux, Joseph E.</creator><creatorcontrib>Romanski, Lizabeth M. ; LeDoux, Joseph E.</creatorcontrib><description>The present study examined whether complete bilateral destruction of auditory cortex would interfere with auditory fear conditioning in rats. Complete destruction of auditory cortex required lesions of temporal neocortical and perirhinal periallocortical areas. Fear conditioning was assessed by measuring freezing and arterial pressure responses elicited by an acoustic stimulus after pairing with footshock. Animals with complete bilateral lesions of auditory cortex showed conditioned arterial pressure and freezing responses comparable to those of unoperated controls. In contrast, bialteral destruction of the acoustic thalamus interfered with the conditioning of both responses. These results demonstrate that the auditory cortex is not required for the conditioning of fear responses to simple acoustic stimuli and add to the growing body of evidence that fear conditioning can be mediated by subcortical (amygdaloid) projections of the acoustic thalamus.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(92)90379-L</identifier><identifier>PMID: 1454221</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acoustic Stimulation ; Amygdala ; Anatomical correlates of behavior ; Animals ; Auditory ; Auditory cortex ; Auditory Cortex - physiology ; Auditory Pathways - physiology ; Behavior, Animal - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Blood Pressure - physiology ; Classical conditioning ; Conditioning, Classical - physiology ; Cortico-amygdala ; Electroshock ; Fear - physiology ; Fear conditioning ; Fundamental and applied biological sciences. Psychology ; Male ; Medial geniculate ; Perirhinal cortex ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Temporal Lobe - physiology ; Thalamoamygdala ; Thalamus - physiology</subject><ispartof>Neuroscience letters, 1992-08, Vol.142 (2), p.228-232</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-aa85d4de2cfbdc770ce6689f252fc1c7997904ee0670f6af8afb79e4c37c8fb53</citedby><cites>FETCH-LOGICAL-c468t-aa85d4de2cfbdc770ce6689f252fc1c7997904ee0670f6af8afb79e4c37c8fb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(92)90379-L$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5476279$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1454221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romanski, Lizabeth M.</creatorcontrib><creatorcontrib>LeDoux, Joseph E.</creatorcontrib><title>Bilateral destruction of neocortical and perirhinal projection targets of the acoustic thalamus does not disrupt auditory fear conditioning</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The present study examined whether complete bilateral destruction of auditory cortex would interfere with auditory fear conditioning in rats. Complete destruction of auditory cortex required lesions of temporal neocortical and perirhinal periallocortical areas. Fear conditioning was assessed by measuring freezing and arterial pressure responses elicited by an acoustic stimulus after pairing with footshock. Animals with complete bilateral lesions of auditory cortex showed conditioned arterial pressure and freezing responses comparable to those of unoperated controls. In contrast, bialteral destruction of the acoustic thalamus interfered with the conditioning of both responses. These results demonstrate that the auditory cortex is not required for the conditioning of fear responses to simple acoustic stimuli and add to the growing body of evidence that fear conditioning can be mediated by subcortical (amygdaloid) projections of the acoustic thalamus.</description><subject>Acoustic Stimulation</subject><subject>Amygdala</subject><subject>Anatomical correlates of behavior</subject><subject>Animals</subject><subject>Auditory</subject><subject>Auditory cortex</subject><subject>Auditory Cortex - physiology</subject><subject>Auditory Pathways - physiology</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - physiology</subject><subject>Classical conditioning</subject><subject>Conditioning, Classical - physiology</subject><subject>Cortico-amygdala</subject><subject>Electroshock</subject><subject>Fear - physiology</subject><subject>Fear conditioning</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medial geniculate</subject><subject>Perirhinal cortex</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Temporal Lobe - physiology</subject><subject>Thalamoamygdala</subject><subject>Thalamus - physiology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFuFSEUhonR1Gv1DTRhYRpdTAWGgWFjYptWm9zEja4JFw4tzVy4AmPSZ_ClZZybutMVOTnff-DwIfSaknNKqPhAesK7XnHyTrH3ivRSddsnaENHyTqpJHuKNo_Ic_SilHtCyEAHfoJOKB84Y3SDfl2EyVTIZsIOSs2zrSFFnDyOkGzKNdjWMtHhA-SQ70Js5SGne1jBavIt1LIE6h1gY9NcWqYVZjL7uWCXoOCYKnah5PlQsZldqCk_YA8mY5tiK9ukEG9fomfeTAVeHc9T9P366tvll2779fPN5adtZ7kYa2fMODjugFm_c1ZKYkGIUXk2MG-plUpJRTgAEZJ4Yfxo_E4q4LaXdvS7oT9FZ-vctsePuW2t96FYmCbTdp6Lln37S6b6_4JU9IIIqhrIV9DmVEoGrw857E1-0JToRZZeTOjFhFZM_5Glty325jh_3u3B_Q2tdlr_7bFvStPgs4k2lEds4FIwudz-ccWgfdrPAFkXGyBacCE3Tdql8O93_AYTR7TT</recordid><startdate>19920817</startdate><enddate>19920817</enddate><creator>Romanski, Lizabeth M.</creator><creator>LeDoux, Joseph E.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920817</creationdate><title>Bilateral destruction of neocortical and perirhinal projection targets of the acoustic thalamus does not disrupt auditory fear conditioning</title><author>Romanski, Lizabeth M. ; LeDoux, Joseph E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-aa85d4de2cfbdc770ce6689f252fc1c7997904ee0670f6af8afb79e4c37c8fb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acoustic Stimulation</topic><topic>Amygdala</topic><topic>Anatomical correlates of behavior</topic><topic>Animals</topic><topic>Auditory</topic><topic>Auditory cortex</topic><topic>Auditory Cortex - physiology</topic><topic>Auditory Pathways - physiology</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - physiology</topic><topic>Classical conditioning</topic><topic>Conditioning, Classical - physiology</topic><topic>Cortico-amygdala</topic><topic>Electroshock</topic><topic>Fear - physiology</topic><topic>Fear conditioning</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medial geniculate</topic><topic>Perirhinal cortex</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Temporal Lobe - physiology</topic><topic>Thalamoamygdala</topic><topic>Thalamus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romanski, Lizabeth M.</creatorcontrib><creatorcontrib>LeDoux, Joseph E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romanski, Lizabeth M.</au><au>LeDoux, Joseph E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bilateral destruction of neocortical and perirhinal projection targets of the acoustic thalamus does not disrupt auditory fear conditioning</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1992-08-17</date><risdate>1992</risdate><volume>142</volume><issue>2</issue><spage>228</spage><epage>232</epage><pages>228-232</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The present study examined whether complete bilateral destruction of auditory cortex would interfere with auditory fear conditioning in rats. Complete destruction of auditory cortex required lesions of temporal neocortical and perirhinal periallocortical areas. Fear conditioning was assessed by measuring freezing and arterial pressure responses elicited by an acoustic stimulus after pairing with footshock. Animals with complete bilateral lesions of auditory cortex showed conditioned arterial pressure and freezing responses comparable to those of unoperated controls. In contrast, bialteral destruction of the acoustic thalamus interfered with the conditioning of both responses. These results demonstrate that the auditory cortex is not required for the conditioning of fear responses to simple acoustic stimuli and add to the growing body of evidence that fear conditioning can be mediated by subcortical (amygdaloid) projections of the acoustic thalamus.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1454221</pmid><doi>10.1016/0304-3940(92)90379-L</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1992-08, Vol.142 (2), p.228-232 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73379293 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acoustic Stimulation Amygdala Anatomical correlates of behavior Animals Auditory Auditory cortex Auditory Cortex - physiology Auditory Pathways - physiology Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences Blood Pressure - physiology Classical conditioning Conditioning, Classical - physiology Cortico-amygdala Electroshock Fear - physiology Fear conditioning Fundamental and applied biological sciences. Psychology Male Medial geniculate Perirhinal cortex Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Temporal Lobe - physiology Thalamoamygdala Thalamus - physiology |
| title | Bilateral destruction of neocortical and perirhinal projection targets of the acoustic thalamus does not disrupt auditory fear conditioning |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T13%3A55%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bilateral%20destruction%20of%20neocortical%20and%20perirhinal%20projection%20targets%20of%20the%20acoustic%20thalamus%20does%20not%20disrupt%20auditory%20fear%20conditioning&rft.jtitle=Neuroscience%20letters&rft.au=Romanski,%20Lizabeth%20M.&rft.date=1992-08-17&rft.volume=142&rft.issue=2&rft.spage=228&rft.epage=232&rft.pages=228-232&rft.issn=0304-3940&rft.eissn=1872-7972&rft.coden=NELED5&rft_id=info:doi/10.1016/0304-3940(92)90379-L&rft_dat=%3Cproquest_cross%3E16360619%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16360619&rft_id=info:pmid/1454221&rft_els_id=030439409290379L&rfr_iscdi=true |