Comparative assessment of inoculum effects on the antimicrobial activity of amoxycillin-clavulanate and piperacillin-tazobactam with extended-spectrum β-lactamase-producing and extended-spectrum β-lactamase-non-producing Escherichia coli isolates

A significant inoculum-size effect has been observed with piperacillin-tazobactam, and has been associated with β-lactamase production in extended-spectrum β-lactamase (ESBL) producers. This association has not been previously studied in the case of amoxycillin-clavulanate. Piperacillin-tazobactam a...

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Veröffentlicht in:	Clinical microbiology and infection 2010-02, Vol.16 (2), p.132-136
Hauptverfasser:	López-Cerero, L., Picón, E., Morillo, C., Hernández, J.R., Docobo, F., Pachón, J., Rodríguez-Bañ, J., Pascual, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amoxicillin-Potassium Clavulanate Combination - pharmacology Amoxycillin-clavulanate Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents beta-Lactamases - biosynthesis Biological and medical sciences Colony Count, Microbial Escherichia coli - drug effects Escherichia coli - enzymology Escherichia coli - isolation & purification Escherichia coli Infections Escherichia coli Proteins - biosynthesis extended-spectrum β-lactamase Humans Infectious diseases inoculum effect Medical sciences Microbial Sensitivity Tests - methods Microbial Viability Penicillanic Acid - analogs & derivatives Penicillanic Acid - pharmacology Pharmacology. Drug treatments Piperacillin - pharmacology piperacillin-tazobactam Time Factors
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