Preclinical Models of Restenosis and Their Application in the Evaluation of Drug-Eluting Stent Systems
Coronary arterial disease (CAD) is the leading cause of death in the United States, the European Union, and Canada. Percutaneous coronary intervention (PCI) has revolutionized the treatment of CAD, and it is the advent of drug-eluting stent (DES) systems that has effectively allayed much of the chal...
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| Veröffentlicht in: | Veterinary Pathology 2010, Vol.47 (1), p.58-76 |
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| creator | Perkins, L.E. Leigh |
| description | Coronary arterial disease (CAD) is the leading cause of death in the United States, the European Union, and Canada. Percutaneous coronary intervention (PCI) has revolutionized the treatment of CAD, and it is the advent of drug-eluting stent (DES) systems that has effectively allayed much of the challenge of restenosis that has plagued the success of PCI through its 30-year history. However, DES systems have not been a panacea: There yet remain the challenges associated with interventions involving bare metallic stents as well as newly arisen concerns related to the application of DES systems. To effectively address these novel and ongoing issues, animal models are relied on both to project the safety and efficacy of endovascular devices and to provide insight into the pathophysiology underlying the vascular response to injury and mechanisms of restenosis. In this review, preclinical models of restenosis are presented, and their application and limitation in the evaluation of device-based interventional technologies for the treatment of CAD are discussed. |
| doi_str_mv | 10.1177/0300985809352978 |
| format | Article |
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| ispartof | Veterinary Pathology, 2010, Vol.47 (1), p.58-76 |
| issn | 0300-9858 1544-2217 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | animal disease models Animals coronary artery disease Coronary Disease - therapy Coronary Restenosis - prevention & control Coronary Restenosis - therapy coronary vessels Disease Models, Animal Dogs drug delivery systems Drug-Eluting Stents - adverse effects endovascular stents equipment performance in-stent restenosis literature reviews medical equipment medical treatment Mice pathophysiology percutaneous coranary intervention Primates Rabbits Rats Sheep Swine transdermal application vascular diseases |
| title | Preclinical Models of Restenosis and Their Application in the Evaluation of Drug-Eluting Stent Systems |
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