Improved Hydrophilic Interaction Chromatography LC/MS of Heparinoids Using a Chip with Postcolumn Makeup Flow

Heparan sulfate (HS) and heparin are linear, heterogeneous carbohydrates of the glycosaminoglycan (GAG) family that are modified by N-acetylation, N-sulfation, O-sulfation, and uronic acid epimerization. HS interacts with growth factors in the extracellular matrix, thereby modulating signaling pathw...

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Veröffentlicht in:	Analytical chemistry (Washington) 2010-01, Vol.82 (2), p.516-522
Hauptverfasser:	Staples, Gregory O, Naimy, Hicham, Yin, Hongfeng, Kileen, Kevin, Kraiczek, Karsten, Costello, Catherine E, Zaia, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Analytical chemistry Biochemistry Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Exact sciences and technology Fundamental and applied biological sciences. Psychology Glycomics - methods Heparan sulfate Heparin - chemistry Heparinoids - analysis Heparinoids - chemistry Heparitin Sulfate - chemistry Mass spectrometry Mass Spectrometry - methods Molecular and cellular biology Other chromatographic methods Spectrometric and optical methods
Online-Zugang:	Volltext
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