PK–PD integration and modeling of marbofloxacin in sheep

The fluoroquinolone antimicrobial drug, marbofloxacin, was administered intravenously (IV) and intramuscularly (IM) to sheep at a dose rate of 2 mg kg −1 in a 2-period cross-over study. Using a tissue cage model of inflammation, the pharmacokinetic properties of marbofloxacin were established for se...

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Veröffentlicht in:	Research in veterinary science 2010-02, Vol.88 (1), p.134-141
Hauptverfasser:	Sidhu, P.K., Landoni, M.F., Aliabadi, F.S., Lees, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Antimicrobial agents Bacteria Cross-Over Studies Dosage selection Dose-Response Relationship, Drug Drug dosages Fluoroquinolones - administration & dosage Fluoroquinolones - pharmacokinetics Fluoroquinolones - therapeutic use Injections, Intramuscular - veterinary Injections, Intravenous - veterinary Laboratory animals Mannheimia haemolytica Mannheimia haemolytica - drug effects Marbofloxacin Metabolic Clearance Rate Microbial Sensitivity Tests Microbiology Pasteurellaceae Infections - drug therapy Pasteurellaceae Infections - veterinary Pharmacokinetic–pharmacodynamic integration PK–PD modeling Plasma Sheep Sheep - metabolism Sheep Diseases - drug therapy Sheep Diseases - microbiology Studies Veterinary medicine
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