SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion

The adaptor protein SETA/CIN85/Ruk is involved in regulating diverse signal transduction pathways, including the internalization of tyrosine kinase receptors via the Cbl ubiquitin ligases, and attenuating PI3K activity by interaction with its regulatory subunit. Here we present evidence for a new as...

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Veröffentlicht in:	Journal of cell science 2003-07, Vol.116 (Pt 14), p.2845-2855
Hauptverfasser:	Schmidt, Mirko H H, Chen, Baihua, Randazzo, Lisa M, Bogler, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adaptor Proteins, Signal Transducing Animals Astrocytes - metabolism Astrocytes - pathology Blotting, Western Calcium - metabolism Carrier Proteins - chemistry Carrier Proteins - metabolism Cell Adhesion Cell Line Cytoskeleton - metabolism Dimerization Electric Impedance Electrophysiology Focal Adhesion Kinase 1 Focal Adhesion Kinase 2 Focal Adhesion Protein-Tyrosine Kinases Glioma - pathology Humans Immunohistochemistry Microscopy, Confocal Microtubules - metabolism Mutation Neoplasm Proteins - chemistry Neoplasm Proteins - metabolism Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Precipitin Tests Protein Binding Protein Structure, Tertiary Protein-Tyrosine Kinases - metabolism Rats Signal Transduction Time Factors Transfection Tubulin - metabolism Ubiquitin - metabolism
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