cPSA and fPSA elimination in African-American men
In all, 22 African-American males undergoing radical prostatectomy for prostate adenocarcinoma had serum drawn for tPSA, cPSA, and total protein concentrations prior to, during, and after operation to determine the respective elimination rates. African-American cPSA was found to fit best a simple fi...
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| Veröffentlicht in: | Prostate cancer and prostatic diseases 2003-06, Vol.6 (2), p.163-168 |
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| creator | Martin, B J Cheli, C Davis, R Ward, M Kokatnur, M Mercante, D Lifsey, D Rayford, W |
| description | In all, 22 African-American males undergoing radical prostatectomy for prostate adenocarcinoma had serum drawn for tPSA, cPSA, and total protein concentrations prior to, during, and after operation to determine the respective elimination rates. African-American cPSA was found to fit best a simple first-order exponential elimination kinetic, with a half-life of 44.6 h. fPSA followed a two-compartment elimination with an
α
-phase elimination of 0.50 h and a
β
-phase half-life of 4.2 h. Our results suggest higher rates of elimination for both cPSA and fPSA in an African-American male population with respect to Caucasians and may account for differences in PSA values between races. |
| doi_str_mv | 10.1038/sj.pcan.4500649 |
| format | Article |
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α
-phase elimination of 0.50 h and a
β
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α
-phase elimination of 0.50 h and a
β
-phase half-life of 4.2 h. Our results suggest higher rates of elimination for both cPSA and fPSA in an African-American male population with respect to Caucasians and may account for differences in PSA values between races.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - ethnology</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>African American men</subject><subject>African Americans</subject><subject>Aged</subject><subject>Beta phase</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cancer surgery</subject><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Diseases</subject><subject>European Continental Ancestry Group</subject><subject>Half-life</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Measurement</subject><subject>Medical examination</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Prostate-specific antigen</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostate-Specific Antigen - pharmacokinetics</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - ethnology</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Reference Values</subject><subject>Urological surgery</subject><issn>1365-7852</issn><issn>1476-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1v1DAQhi0EoqVw5oYikHrL1t8fx6iiBakSSMDZ8jrj1qvEWezkwL_HYVdaiqh88MjzzDszfhF6S_CGYKavym6z9y5tuMBYcvMMnROuZCsk1s9rzKRolRb0DL0qZYcxNsTgl-iMUI0lU-ocEf_1W9e41DdhDWCIY0xujlNqYmq6kGOVb7sR_gTNCOk1ehHcUODN8b5AP24-fr_-1N59uf183d21nms1t5L3PtQBDO-53FKjJWfYuRB0LxQw6WAruJMqkF4yI7AAzKnXIEIQhDnNLtDlQXefp58LlNmOsXgYBpdgWopVjCltuKjgh3_A3bTkVGezVNY8kQrzSr1_kqIGK4UFP0nduwFsTGGas_NrX9sRbSilgqzU5j9UPT2M0U8JQqzvjwou_yp4ADfMD2UalvWby2Pw6gD6PJWSIdh9jqPLvyzBdjXclp1dDbdHw2vFu-Nay3aE_sQfHa4APgClptI95NPeT2n-BisrsWY</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Martin, B J</creator><creator>Cheli, C</creator><creator>Davis, R</creator><creator>Ward, M</creator><creator>Kokatnur, M</creator><creator>Mercante, D</creator><creator>Lifsey, D</creator><creator>Rayford, W</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>cPSA and fPSA elimination in African-American men</title><author>Martin, B J ; Cheli, C ; Davis, R ; Ward, M ; Kokatnur, M ; Mercante, D ; Lifsey, D ; Rayford, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-64dcf13694d46b2986430aaff8d57e36aeb54a67f1d639505e042c8e5ff513a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - ethnology</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>African American men</topic><topic>African Americans</topic><topic>Aged</topic><topic>Beta phase</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cancer surgery</topic><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Diseases</topic><topic>European Continental Ancestry Group</topic><topic>Half-life</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Measurement</topic><topic>Medical examination</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Prostate</topic><topic>Prostate cancer</topic><topic>Prostate-specific antigen</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostate-Specific Antigen - pharmacokinetics</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - ethnology</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Reference Values</topic><topic>Urological surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, B J</creatorcontrib><creatorcontrib>Cheli, C</creatorcontrib><creatorcontrib>Davis, R</creatorcontrib><creatorcontrib>Ward, M</creatorcontrib><creatorcontrib>Kokatnur, M</creatorcontrib><creatorcontrib>Mercante, D</creatorcontrib><creatorcontrib>Lifsey, D</creatorcontrib><creatorcontrib>Rayford, W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Prostate cancer and prostatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, B J</au><au>Cheli, C</au><au>Davis, R</au><au>Ward, M</au><au>Kokatnur, M</au><au>Mercante, D</au><au>Lifsey, D</au><au>Rayford, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>cPSA and fPSA elimination in African-American men</atitle><jtitle>Prostate cancer and prostatic diseases</jtitle><stitle>Prostate Cancer Prostatic Dis</stitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>6</volume><issue>2</issue><spage>163</spage><epage>168</epage><pages>163-168</pages><issn>1365-7852</issn><eissn>1476-5608</eissn><abstract>In all, 22 African-American males undergoing radical prostatectomy for prostate adenocarcinoma had serum drawn for tPSA, cPSA, and total protein concentrations prior to, during, and after operation to determine the respective elimination rates. African-American cPSA was found to fit best a simple first-order exponential elimination kinetic, with a half-life of 44.6 h. fPSA followed a two-compartment elimination with an
α
-phase elimination of 0.50 h and a
β
-phase half-life of 4.2 h. Our results suggest higher rates of elimination for both cPSA and fPSA in an African-American male population with respect to Caucasians and may account for differences in PSA values between races.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>12806377</pmid><doi>10.1038/sj.pcan.4500649</doi><tpages>6</tpages></addata></record> |
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| ispartof | Prostate cancer and prostatic diseases, 2003-06, Vol.6 (2), p.163-168 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Adenocarcinoma Adenocarcinoma - ethnology Adenocarcinoma - pathology Adult African American men African Americans Aged Beta phase Biomedical and Life Sciences Biomedicine Cancer Research Cancer surgery Care and treatment Diagnosis Diseases European Continental Ancestry Group Half-life Health aspects Humans Male Measurement Medical examination Men Middle Aged Prostate Prostate cancer Prostate-specific antigen Prostate-Specific Antigen - blood Prostate-Specific Antigen - pharmacokinetics Prostatectomy Prostatic Neoplasms - ethnology Prostatic Neoplasms - pathology Reference Values Urological surgery |
| title | cPSA and fPSA elimination in African-American men |
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