Protein translocation across the endoplasmic reticulum membrane in cold-adapted organisms

Secretory proteins enter the secretory pathway by translocation across the membrane of the endoplasmic reticulum (ER) via a channel formed primarily by the Sec61 protein. Protein translocation is highly temperature dependent in mesophilic organisms. We asked whether the protein translocation machine...

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Veröffentlicht in:	Journal of cell science 2003-07, Vol.116 (Pt 14), p.2875-2883
Hauptverfasser:	Römisch, Karin, Collie, Nicola, Soto, Nelyn, Logue, James, Lindsay, Margaret, Scheper, Wiep, Cheng, Chi-Hing C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cold Temperature Cryptococcus - metabolism DNA, Complementary - metabolism Endoplasmic Reticulum - metabolism Fishes Fungal Proteins - chemistry Intracellular Membranes - metabolism Lipids - chemistry Liver - metabolism Membrane Proteins - chemistry Membrane Proteins - physiology Membrane Transport Proteins Microscopy, Electron Microsomes - metabolism Microsomes, Liver - chemistry Models, Biological Molecular Sequence Data Protein Processing, Post-Translational Protein Structure, Tertiary Protein Transport RNA - chemistry Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins SEC Translocation Channels Sequence Homology, Amino Acid Temperature
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