In vivo dynamic optical coherence elastography using a ring actuator
We present a novel sample arm arrangement for dynamic optical coherence elastography based on excitation by a ring actuator. The actuator enables coincident excitation and imaging to be performed on a sample, facilitating in vivo operation. Sub-micrometer vibrations in the audio frequency range were...
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| Veröffentlicht in: | Optics express 2009-11, Vol.17 (24), p.21762-21772 |
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| container_issue | 24 |
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| container_title | Optics express |
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| creator | Kennedy, Brendan F Hillman, Timothy R McLaughlin, Robert A Quirk, Bryden C Sampson, David D |
| description | We present a novel sample arm arrangement for dynamic optical coherence elastography based on excitation by a ring actuator. The actuator enables coincident excitation and imaging to be performed on a sample, facilitating in vivo operation. Sub-micrometer vibrations in the audio frequency range were coupled to samples that were imaged using optical coherence tomography. The resulting vibration amplitude and microstrain maps are presented for bilayer silicone phantoms and multiple skin sites on a human subject. Contrast based on the differing elastic properties is shown, notably between the epidermis and dermis. The results constitute the first demonstration of a practical means of performing in vivo dynamic optical coherence elastography on a human subject. |
| doi_str_mv | 10.1364/oe.17.021762 |
| format | Article |
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| ispartof | Optics express, 2009-11, Vol.17 (24), p.21762-21772 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Algorithms Elasticity Imaging Techniques - instrumentation Elasticity Imaging Techniques - methods Equipment Design Humans Image Interpretation, Computer-Assisted - methods Interferometry - methods Male Phantoms, Imaging Scattering, Radiation Skin - pathology Tomography, Optical Coherence - methods |
| title | In vivo dynamic optical coherence elastography using a ring actuator |
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