Thymidylate Synthase But Not Excision Repair Cross-Complementation Group 1 Tumor Expression Predicts Outcome in Patients With Malignant Pleural Mesothelioma Treated With Pemetrexed-Based Chemotherapy

The relationship between thymidylate synthase (TS) expression and outcome in patients with malignant pleural mesothelioma (MPM) treated with pemetrexed (P) was retrospectively evaluated. Sixty histologically confirmed patients with MPM previously treated with P and platinum (45 of 60) or as single a...

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Veröffentlicht in:	Journal of clinical oncology 2010-03, Vol.28 (9), p.1534-1539
Hauptverfasser:	RIGHI, Luisella, PAPOTTI, Mauro G, CEPPI, Paolo, BILLE, Andrea, BACILLO, Elisa, MOLINARO, Luca, RUFFINI, Enrico, SCAGLIOTTI, Giorgio V, SELVAGGI, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antimetabolites, Antineoplastic - therapeutic use Biological and medical sciences Biomarkers - metabolism DNA Helicases - biosynthesis Female Gene Expression Regulation, Neoplastic Glutamates - therapeutic use Guanine - analogs & derivatives Guanine - therapeutic use Humans Male Medical sciences Mesothelioma - drug therapy Mesothelioma - metabolism Middle Aged Pemetrexed Pleural Neoplasms - drug therapy Pleural Neoplasms - metabolism Pneumology Predictive Value of Tests Prognosis Retrospective Studies Thymidylate Synthase - antagonists & inhibitors Thymidylate Synthase - biosynthesis Treatment Outcome Tumors Tumors of the respiratory system and mediastinum
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