Protective effect of methylprednisolone on warm ischemia-reperfusion injury in a cholestatic rat liver
Abstract Background Cholestasis has been identified as a risk factor for oxidative stress, and it potentially enhances after ischemic-reperfusion injury. The aim of this study was to evaluate the role of methylprednisolone on warm ischemia-reperfusion injury in the presence of cholestasis. Methods A...
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| Veröffentlicht in: | The American journal of surgery 2010-03, Vol.199 (3), p.377-381 |
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| creator | Subhas, Gokulakkrishna, M.D., M.R.C.S Gupta, Aditya, M.D Bakston, Daniel, M.D Silberberg, Boris, M.D Lobocki, Cathy, M.S Andrus, Lee, L.V.T Decker, Melissa, L.V.T Mittal, Vijay K., M.D., F.A.C.S Jacobs, Michael J., M.D., F.A.C.S |
| description | Abstract Background Cholestasis has been identified as a risk factor for oxidative stress, and it potentially enhances after ischemic-reperfusion injury. The aim of this study was to evaluate the role of methylprednisolone on warm ischemia-reperfusion injury in the presence of cholestasis. Methods A reversible cholestatic rat model was created. After 7 days, rats received 30 mg/kg of intravenous methylprednisolone 2 hours before ischemia, followed by 30 minutes of ischemia. Rats were euthanized 24 hours after ischemia. Serum aspartate aminotransferase and interleukin-6 were measured, and the liver was harvested for histology and myeloperoxidase estimation. Results Methylprednisolone had a protective effect, with a statistically significant decrease in aspartate aminotransferase ( P = .01) and a trend toward decreased levels of interleukin-6 ( P = .07). Histology showed a significant difference in architectural distortion ( P = .01), cytoplasmic vacuolation ( P = .01), and nodular hepatocellular necrosis ( P = .04). Conclusions Methylprednisolone attenuated the ischemic-reperfusion injury in the presence of cholestasis and can be considered for clinical use in the presence of cholestasis. |
| doi_str_mv | 10.1016/j.amjsurg.2009.09.012 |
| format | Article |
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The aim of this study was to evaluate the role of methylprednisolone on warm ischemia-reperfusion injury in the presence of cholestasis. Methods A reversible cholestatic rat model was created. After 7 days, rats received 30 mg/kg of intravenous methylprednisolone 2 hours before ischemia, followed by 30 minutes of ischemia. Rats were euthanized 24 hours after ischemia. Serum aspartate aminotransferase and interleukin-6 were measured, and the liver was harvested for histology and myeloperoxidase estimation. Results Methylprednisolone had a protective effect, with a statistically significant decrease in aspartate aminotransferase ( P = .01) and a trend toward decreased levels of interleukin-6 ( P = .07). Histology showed a significant difference in architectural distortion ( P = .01), cytoplasmic vacuolation ( P = .01), and nodular hepatocellular necrosis ( P = .04). Conclusions Methylprednisolone attenuated the ischemic-reperfusion injury in the presence of cholestasis and can be considered for clinical use in the presence of cholestasis.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2009.09.012</identifier><identifier>PMID: 20226914</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Aspartate aminotransferase ; Bile ; Biopsy ; Cholestasis ; Cholestasis, Intrahepatic - complications ; Cytokines ; Distortion ; Enzymes ; Gallbladder diseases ; Gastroenterology ; Glucocorticoids - therapeutic use ; Hepatology ; Histology ; Injuries ; Interleukin 6 ; Interleukins ; Intravenous administration ; Ischemia ; Ischemia-reperfusion injury ; Laboratories ; Liver ; Liver resection ; Male ; Methylprednisolone ; Methylprednisolone - therapeutic use ; Neutrophils ; Oxidative stress ; Peroxidase ; Rats ; Rats, Sprague-Dawley ; Reperfusion ; Reperfusion Injury - complications ; Reperfusion Injury - prevention & control ; Risk factors ; Rodents ; Statistical analysis ; Surgery ; Warm Ischemia</subject><ispartof>The American journal of surgery, 2010-03, Vol.199 (3), p.377-381</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>Copyright (c) 2010 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 1, 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-753551761651713276a3fc35d45181199841918e9ea95e28ca3d2ad5ad6918c43</citedby><cites>FETCH-LOGICAL-c447t-753551761651713276a3fc35d45181199841918e9ea95e28ca3d2ad5ad6918c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1925902933?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978,64366,64368,64370,72220</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20226914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Subhas, Gokulakkrishna, M.D., M.R.C.S</creatorcontrib><creatorcontrib>Gupta, Aditya, M.D</creatorcontrib><creatorcontrib>Bakston, Daniel, M.D</creatorcontrib><creatorcontrib>Silberberg, Boris, M.D</creatorcontrib><creatorcontrib>Lobocki, Cathy, M.S</creatorcontrib><creatorcontrib>Andrus, Lee, L.V.T</creatorcontrib><creatorcontrib>Decker, Melissa, L.V.T</creatorcontrib><creatorcontrib>Mittal, Vijay K., M.D., F.A.C.S</creatorcontrib><creatorcontrib>Jacobs, Michael J., M.D., F.A.C.S</creatorcontrib><title>Protective effect of methylprednisolone on warm ischemia-reperfusion injury in a cholestatic rat liver</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Cholestasis has been identified as a risk factor for oxidative stress, and it potentially enhances after ischemic-reperfusion injury. The aim of this study was to evaluate the role of methylprednisolone on warm ischemia-reperfusion injury in the presence of cholestasis. Methods A reversible cholestatic rat model was created. After 7 days, rats received 30 mg/kg of intravenous methylprednisolone 2 hours before ischemia, followed by 30 minutes of ischemia. Rats were euthanized 24 hours after ischemia. Serum aspartate aminotransferase and interleukin-6 were measured, and the liver was harvested for histology and myeloperoxidase estimation. Results Methylprednisolone had a protective effect, with a statistically significant decrease in aspartate aminotransferase ( P = .01) and a trend toward decreased levels of interleukin-6 ( P = .07). Histology showed a significant difference in architectural distortion ( P = .01), cytoplasmic vacuolation ( P = .01), and nodular hepatocellular necrosis ( P = .04). Conclusions Methylprednisolone attenuated the ischemic-reperfusion injury in the presence of cholestasis and can be considered for clinical use in the presence of cholestasis.</description><subject>Animals</subject><subject>Aspartate aminotransferase</subject><subject>Bile</subject><subject>Biopsy</subject><subject>Cholestasis</subject><subject>Cholestasis, Intrahepatic - complications</subject><subject>Cytokines</subject><subject>Distortion</subject><subject>Enzymes</subject><subject>Gallbladder diseases</subject><subject>Gastroenterology</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Hepatology</subject><subject>Histology</subject><subject>Injuries</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Intravenous administration</subject><subject>Ischemia</subject><subject>Ischemia-reperfusion injury</subject><subject>Laboratories</subject><subject>Liver</subject><subject>Liver resection</subject><subject>Male</subject><subject>Methylprednisolone</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Neutrophils</subject><subject>Oxidative stress</subject><subject>Peroxidase</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reperfusion</subject><subject>Reperfusion Injury - complications</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Warm Ischemia</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFUt-L1DAQDnLirad_gkfgHnzqmkmaNnlRjsNfcKCgPoeYTm9T02ZN2pP9703ZVeFehCEzId98mZlvCHkBbAsMmlfD1o5DXtLdljOmt6sBf0Q2oFpdgVLijGwYY7zSDbBz8jTnoVwBavGEnHPGeaOh3pD-c4ozutnfI8W-LxGNPR1x3h3CPmE3-RxDnJDGif6yaaQ-ux2O3lYJ95j6Jfvy4qdhSYfiqKVuFwPm2c7e0WRnGgp1ekYe9zZkfH7yF-Tbu7dfbz5Ut5_ef7y5vq1cXbdz1UohJbQNNOUEwdvGit4J2dUSFIDWqgYNCjVaLZErZ0XHbSdtV7pRrhYX5OWRd5_iz6WUYcZSMIZgJ4xLNq0QrVJMqIK8eoAc4pKmUpwBzaVmXAtRUPKIcinmnLA3--RHmw4GmFl1MIM56WBWHcxqwEve5Yl9-T5i9zfrz-AL4M0RgGUa9x6Tyc7j5LDzqYhguuj_-8XrBwwu-Mk7G37gAfO_bkzmhpkv6zKsu8A0Y62spfgNM8Kwhw</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Subhas, Gokulakkrishna, M.D., M.R.C.S</creator><creator>Gupta, Aditya, M.D</creator><creator>Bakston, Daniel, M.D</creator><creator>Silberberg, Boris, M.D</creator><creator>Lobocki, Cathy, M.S</creator><creator>Andrus, Lee, L.V.T</creator><creator>Decker, Melissa, L.V.T</creator><creator>Mittal, Vijay K., M.D., F.A.C.S</creator><creator>Jacobs, Michael J., M.D., F.A.C.S</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>Protective effect of methylprednisolone on warm ischemia-reperfusion injury in a cholestatic rat liver</title><author>Subhas, Gokulakkrishna, M.D., M.R.C.S ; Gupta, Aditya, M.D ; Bakston, Daniel, M.D ; Silberberg, Boris, M.D ; Lobocki, Cathy, M.S ; Andrus, Lee, L.V.T ; Decker, Melissa, L.V.T ; Mittal, Vijay K., M.D., F.A.C.S ; Jacobs, Michael J., M.D., F.A.C.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-753551761651713276a3fc35d45181199841918e9ea95e28ca3d2ad5ad6918c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Aspartate aminotransferase</topic><topic>Bile</topic><topic>Biopsy</topic><topic>Cholestasis</topic><topic>Cholestasis, Intrahepatic - complications</topic><topic>Cytokines</topic><topic>Distortion</topic><topic>Enzymes</topic><topic>Gallbladder diseases</topic><topic>Gastroenterology</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Hepatology</topic><topic>Histology</topic><topic>Injuries</topic><topic>Interleukin 6</topic><topic>Interleukins</topic><topic>Intravenous administration</topic><topic>Ischemia</topic><topic>Ischemia-reperfusion injury</topic><topic>Laboratories</topic><topic>Liver</topic><topic>Liver resection</topic><topic>Male</topic><topic>Methylprednisolone</topic><topic>Methylprednisolone - therapeutic use</topic><topic>Neutrophils</topic><topic>Oxidative stress</topic><topic>Peroxidase</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reperfusion</topic><topic>Reperfusion Injury - complications</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Risk factors</topic><topic>Rodents</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Warm Ischemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Subhas, Gokulakkrishna, M.D., M.R.C.S</creatorcontrib><creatorcontrib>Gupta, Aditya, M.D</creatorcontrib><creatorcontrib>Bakston, Daniel, M.D</creatorcontrib><creatorcontrib>Silberberg, Boris, M.D</creatorcontrib><creatorcontrib>Lobocki, Cathy, M.S</creatorcontrib><creatorcontrib>Andrus, Lee, L.V.T</creatorcontrib><creatorcontrib>Decker, Melissa, L.V.T</creatorcontrib><creatorcontrib>Mittal, Vijay K., M.D., F.A.C.S</creatorcontrib><creatorcontrib>Jacobs, Michael J., M.D., F.A.C.S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Subhas, Gokulakkrishna, M.D., M.R.C.S</au><au>Gupta, Aditya, M.D</au><au>Bakston, Daniel, M.D</au><au>Silberberg, Boris, M.D</au><au>Lobocki, Cathy, M.S</au><au>Andrus, Lee, L.V.T</au><au>Decker, Melissa, L.V.T</au><au>Mittal, Vijay K., M.D., F.A.C.S</au><au>Jacobs, Michael J., M.D., F.A.C.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of methylprednisolone on warm ischemia-reperfusion injury in a cholestatic rat liver</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>199</volume><issue>3</issue><spage>377</spage><epage>381</epage><pages>377-381</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Abstract Background Cholestasis has been identified as a risk factor for oxidative stress, and it potentially enhances after ischemic-reperfusion injury. The aim of this study was to evaluate the role of methylprednisolone on warm ischemia-reperfusion injury in the presence of cholestasis. Methods A reversible cholestatic rat model was created. After 7 days, rats received 30 mg/kg of intravenous methylprednisolone 2 hours before ischemia, followed by 30 minutes of ischemia. Rats were euthanized 24 hours after ischemia. Serum aspartate aminotransferase and interleukin-6 were measured, and the liver was harvested for histology and myeloperoxidase estimation. Results Methylprednisolone had a protective effect, with a statistically significant decrease in aspartate aminotransferase ( P = .01) and a trend toward decreased levels of interleukin-6 ( P = .07). Histology showed a significant difference in architectural distortion ( P = .01), cytoplasmic vacuolation ( P = .01), and nodular hepatocellular necrosis ( P = .04). Conclusions Methylprednisolone attenuated the ischemic-reperfusion injury in the presence of cholestasis and can be considered for clinical use in the presence of cholestasis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20226914</pmid><doi>10.1016/j.amjsurg.2009.09.012</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Aspartate aminotransferase Bile Biopsy Cholestasis Cholestasis, Intrahepatic - complications Cytokines Distortion Enzymes Gallbladder diseases Gastroenterology Glucocorticoids - therapeutic use Hepatology Histology Injuries Interleukin 6 Interleukins Intravenous administration Ischemia Ischemia-reperfusion injury Laboratories Liver Liver resection Male Methylprednisolone Methylprednisolone - therapeutic use Neutrophils Oxidative stress Peroxidase Rats Rats, Sprague-Dawley Reperfusion Reperfusion Injury - complications Reperfusion Injury - prevention & control Risk factors Rodents Statistical analysis Surgery Warm Ischemia |
| title | Protective effect of methylprednisolone on warm ischemia-reperfusion injury in a cholestatic rat liver |
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