Collagen V and vascular injury promote lung architectural changes in systemic sclerosis

Background: Systemic sclerosis (SSc) is a multisystem disorder characterized by inflammation, fibrosis and vascular damage. The aim of this study was to evaluate the interactions between basement membrane disruption, endothelial injury and collagen V deposition on the vascular wall, as well as thei...

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Veröffentlicht in:	The clinical respiratory journal 2009-07, Vol.3 (3), p.135-142
Hauptverfasser:	Parra, Edwin Roger, Aguiar Jr, Armando Costa, Teodoro, Walcy Rosolia, De Souza, Romy, Yoshinari, Natalino Hajime, Capelozzi, Vera Luiza
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Apoptosis Basement Membrane - pathology Collagen - metabolism Collagen - ultrastructure collagen V electron microscopy endothelial apoptosis Endothelial Cells - metabolism Endothelial Cells - pathology Female Fluorescent Antibody Technique Humans Immunoenzyme Techniques In Situ Nick-End Labeling Lung - pathology Lung - physiopathology Male Middle Aged pulmonary function tests Respiratory Function Tests Scleroderma, Systemic - pathology Scleroderma, Systemic - physiopathology systemic sclerosis
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