A structural informatics approach to mine kinase knowledge bases

In this paper, we describe a combination of structural informatics approaches developed to mine data extracted from existing structure knowledge bases (Protein Data Bank and the GVK database) with a focus on kinase ATP-binding site data. In contrast to existing systems that retrieve and analyze prot...

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Veröffentlicht in:	Drug discovery today 2010-03, Vol.15 (5), p.203-209
Hauptverfasser:	Brooijmans, Natasja, Mobilio, Dominick, Walker, Gary, Nilakantan, Ramaswamy, Denny, Rajiah A., Feyfant, Eric, Diller, David, Bikker, Jack, Humblet, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Crystallography, X-Ray Humans Informatics - methods Informatics - trends Knowledge Bases Molecular Structure Protein Kinases - chemistry Protein Kinases - genetics Structure-Activity Relationship
Online-Zugang:	Volltext
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