Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice

Melanin-concentrating hormone (MCH), which is a neuropeptide expressed in the hypothalamus of the brain, is involved in regulating feeding behavior and energy homeostasis via the MCH 1 receptor in rodents. It is widely considered that MCH 1 receptor antagonists are worthy of development for medical...

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Veröffentlicht in:	European journal of pharmacology 2009-12, Vol.624 (1), p.77-83
Hauptverfasser:	Ito, Masahiko, Ishihara, Akane, Gomori, Akira, Egashira, Shinichiro, Matsushita, Hiroko, Mashiko, Satoshi, Ito, Junko, Ito, Makoto, Nakase, Kazuho, Haga, Yuji, Iwaasa, Hisashi, Suzuki, Takao, Ohtake, Norikazu, Moriya, Minoru, Sato, Nagaaki, MacNeil, Douglas J., Takenaga, Norihiro, Tokita, Shigeru, Kanatani, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Feed Animals Anti-Obesity Agents - pharmacology Anti-Obesity Agents - therapeutic use Biological and medical sciences Diet Dose-Response Relationship, Drug Medical sciences Melanin-concentrating hormone 1-receptor Antagonist Metabolic diseases Mice Obesity Obesity - chemically induced Obesity - drug therapy Obesity - metabolism Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Receptor occupancy Receptors, Pituitary Hormone - antagonists & inhibitors Receptors, Pituitary Hormone - metabolism Weight Gain - drug effects Weight Gain - physiology
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