Inhibition of CYP3A by Erythromycin: In Vitro-In Vivo Correlation in Rats

The prediction of in vivo drug-drug interactions from in vitro enzyme inhibition parameters remains challenging, particularly when time-dependent inhibition occurs. This study was designed to examine the accuracy of in vitro-derived parameters for the prediction of inhibition of CYP3A by erythromyci...

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Veröffentlicht in:	Drug metabolism and disposition 2010-01, Vol.38 (1), p.61-72
Hauptverfasser:	Zhang, Xin, Galinsky, Raymond E., Kimura, Robert E., Quinney, Sara K., Jones, David R., Hall, Stephen D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Area Under Curve Aryl Hydrocarbon Hydroxylases - genetics Biocatalysis - drug effects Biological and medical sciences Computer Simulation Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 Enzyme System - drug effects Cytochrome P-450 Enzyme System - metabolism Drug Interactions - physiology Erythromycin - administration & dosage Erythromycin - metabolism Erythromycin - pharmacology Gene Expression - drug effects Gene Expression - genetics Kinetics Liver - drug effects Liver - enzymology Male Medical sciences Membrane Proteins - genetics Microsomes, Liver - drug effects Microsomes, Liver - enzymology Midazolam - analogs & derivatives Midazolam - blood Midazolam - metabolism Midazolam - pharmacokinetics Models, Biological Pharmacology. Drug treatments Rats Rats, Sprague-Dawley
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