Multichannel Intraluminal Impedance Measurement of Gastroesophageal Reflux in Patients with Different Stages of Morbid Obesity
Background Obesity is now one of the world’s major chronic diseases. The etiology of the severe comorbid conditions associated with morbid obesity is not fully understood, and in particular the relationship between gastroesophageal reflux and obesity. Methods Sixty-seven patients were enrolled in th...
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| Veröffentlicht in: | Obesity surgery 2009-11, Vol.19 (11), p.1522-1529 |
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| creator | Schneider, Juliane M.E. Brücher, Björn L.D.M. Küper, Markus Saemann, Kathrin Königsrainer, Alfred Schneider, Joachim H. |
| description | Background
Obesity is now one of the world’s major chronic diseases. The etiology of the severe comorbid conditions associated with morbid obesity is not fully understood, and in particular the relationship between gastroesophageal reflux and obesity.
Methods
Sixty-seven patients were enrolled in this prospective study. Patients and control individuals were divided into four subgroups according to their body mass index (BMI). Esophageal motility was assessed using a conventional water-perfused esophageal manometry catheter, and 24-h pH-metry was carried out using multichannel intraluminal impedance equipment.
Results
In the group with the highest BMI (>50), contraction amplitudes in the middle and distal esophagus were significantly higher in comparison both with the control group and groups with a lower BMI (
P
|
| doi_str_mv | 10.1007/s11695-008-9624-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733785551</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733785551</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-55c43da53db8e1235b6b34b74479a09322375fc7bc796361e1841fbaaca94a2a3</originalsourceid><addsrcrecordid>eNp9kUtrFTEYhoMo9lj9AW4kuLGb0dwml6VUWws9VLysQ5L5pidlLsckg3bjbzfDOVAQdBU-8rxvPvIg9JKSt5QQ9S5TKk3bEKIbI5lo5CO0oapORDD9GG2IkaTRhvET9CznO0IYlYw9RSdUS6G1kRv0e7sMJYadmyYY8NVUkhuWMU6uDuMeOjcFwFtweUkwwlTw3ONLl0uaIc_7nbuFSn6Bflh-4Tjhz67ESmX8M5Yd_hD7HtKa-loqmdfwdk4-dvjGQ47l_jl60rshw4vjeYq-X3z8dv6pub65vDp_f90EQXhp2jYI3rmWd14DZbz10nPhlRDKOGI4Y1y1fVA-KCO5pEC1oL13LjgjHHP8FL059O7T_GOBXOwYc4BhcBPMS7aKc6XbtqWVPPsvSTVXnFDOSEVf_4XezUuqX5dtXYgxrdTaRw9QSHPOCXq7T3F06d5SYleL9mDRVot2tWhlzbw6Fi9-hO4hcdRWAXYAcr2abiE9vPzv1j8I_Khu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223228771</pqid></control><display><type>article</type><title>Multichannel Intraluminal Impedance Measurement of Gastroesophageal Reflux in Patients with Different Stages of Morbid Obesity</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Schneider, Juliane M.E. ; Brücher, Björn L.D.M. ; Küper, Markus ; Saemann, Kathrin ; Königsrainer, Alfred ; Schneider, Joachim H.</creator><creatorcontrib>Schneider, Juliane M.E. ; Brücher, Björn L.D.M. ; Küper, Markus ; Saemann, Kathrin ; Königsrainer, Alfred ; Schneider, Joachim H.</creatorcontrib><description>Background
Obesity is now one of the world’s major chronic diseases. The etiology of the severe comorbid conditions associated with morbid obesity is not fully understood, and in particular the relationship between gastroesophageal reflux and obesity.
Methods
Sixty-seven patients were enrolled in this prospective study. Patients and control individuals were divided into four subgroups according to their body mass index (BMI). Esophageal motility was assessed using a conventional water-perfused esophageal manometry catheter, and 24-h pH-metry was carried out using multichannel intraluminal impedance equipment.
Results
In the group with the highest BMI (>50), contraction amplitudes in the middle and distal esophagus were significantly higher in comparison both with the control group and groups with a lower BMI (
P
< 0.05). Lower esophageal sphincter pressure was reduced in the majority of patients with morbid obesity and differed significantly from the control group (
P
< 0.001). Significant differences between the control group and the patient groups were also observed on 24-h pH-metry (
P
< 0.05). The 24-h impedance measurements distinguished between acid and nonacid status and between the upright and recumbent positions. The total number of reflux episodes differed significantly between the control and patient groups and between groups III and IV, with lower and higher BMI values (
P
< 0.008 and
P
< 0.05, respectively).
Conclusions
The impedance data obtained in this study confirm that patients with morbid obesity are at risk of developing gastroesophageal reflux disease. However, there is no evidence of a direct correlation between the severity of reflux and the extent of obesity.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-008-9624-6</identifier><identifier>PMID: 18648896</identifier><language>eng</language><publisher>New York: Springer New York</publisher><subject>Adult ; Body Mass Index ; Esophageal pH Monitoring ; Esophageal Spasm, Diffuse - physiopathology ; Esophageal Sphincter, Lower - physiopathology ; Female ; Gastroesophageal reflux ; Gastroesophageal Reflux - epidemiology ; Gastroesophageal Reflux - pathology ; Gastroesophageal Reflux - physiopathology ; Humans ; Male ; Manometry - methods ; Measurement ; Medicine ; Medicine & Public Health ; Middle Aged ; Obesity ; Obesity, Morbid - epidemiology ; Obesity, Morbid - pathology ; Obesity, Morbid - physiopathology ; Postprandial Period ; Posture ; Prevalence ; Prospective Studies ; Research Article ; Risk factors ; Severity of Illness Index ; Surgery ; Young Adult</subject><ispartof>Obesity surgery, 2009-11, Vol.19 (11), p.1522-1529</ispartof><rights>Springer Science + Business Media, LLC 2008</rights><rights>Springer Science + Business Media, LLC 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-55c43da53db8e1235b6b34b74479a09322375fc7bc796361e1841fbaaca94a2a3</citedby><cites>FETCH-LOGICAL-c403t-55c43da53db8e1235b6b34b74479a09322375fc7bc796361e1841fbaaca94a2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-008-9624-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-008-9624-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18648896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schneider, Juliane M.E.</creatorcontrib><creatorcontrib>Brücher, Björn L.D.M.</creatorcontrib><creatorcontrib>Küper, Markus</creatorcontrib><creatorcontrib>Saemann, Kathrin</creatorcontrib><creatorcontrib>Königsrainer, Alfred</creatorcontrib><creatorcontrib>Schneider, Joachim H.</creatorcontrib><title>Multichannel Intraluminal Impedance Measurement of Gastroesophageal Reflux in Patients with Different Stages of Morbid Obesity</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Obesity is now one of the world’s major chronic diseases. The etiology of the severe comorbid conditions associated with morbid obesity is not fully understood, and in particular the relationship between gastroesophageal reflux and obesity.
Methods
Sixty-seven patients were enrolled in this prospective study. Patients and control individuals were divided into four subgroups according to their body mass index (BMI). Esophageal motility was assessed using a conventional water-perfused esophageal manometry catheter, and 24-h pH-metry was carried out using multichannel intraluminal impedance equipment.
Results
In the group with the highest BMI (>50), contraction amplitudes in the middle and distal esophagus were significantly higher in comparison both with the control group and groups with a lower BMI (
P
< 0.05). Lower esophageal sphincter pressure was reduced in the majority of patients with morbid obesity and differed significantly from the control group (
P
< 0.001). Significant differences between the control group and the patient groups were also observed on 24-h pH-metry (
P
< 0.05). The 24-h impedance measurements distinguished between acid and nonacid status and between the upright and recumbent positions. The total number of reflux episodes differed significantly between the control and patient groups and between groups III and IV, with lower and higher BMI values (
P
< 0.008 and
P
< 0.05, respectively).
Conclusions
The impedance data obtained in this study confirm that patients with morbid obesity are at risk of developing gastroesophageal reflux disease. However, there is no evidence of a direct correlation between the severity of reflux and the extent of obesity.</description><subject>Adult</subject><subject>Body Mass Index</subject><subject>Esophageal pH Monitoring</subject><subject>Esophageal Spasm, Diffuse - physiopathology</subject><subject>Esophageal Sphincter, Lower - physiopathology</subject><subject>Female</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - epidemiology</subject><subject>Gastroesophageal Reflux - pathology</subject><subject>Gastroesophageal Reflux - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Manometry - methods</subject><subject>Measurement</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - epidemiology</subject><subject>Obesity, Morbid - pathology</subject><subject>Obesity, Morbid - physiopathology</subject><subject>Postprandial Period</subject><subject>Posture</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Research Article</subject><subject>Risk factors</subject><subject>Severity of Illness Index</subject><subject>Surgery</subject><subject>Young Adult</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtrFTEYhoMo9lj9AW4kuLGb0dwml6VUWws9VLysQ5L5pidlLsckg3bjbzfDOVAQdBU-8rxvPvIg9JKSt5QQ9S5TKk3bEKIbI5lo5CO0oapORDD9GG2IkaTRhvET9CznO0IYlYw9RSdUS6G1kRv0e7sMJYadmyYY8NVUkhuWMU6uDuMeOjcFwFtweUkwwlTw3ONLl0uaIc_7nbuFSn6Bflh-4Tjhz67ESmX8M5Yd_hD7HtKa-loqmdfwdk4-dvjGQ47l_jl60rshw4vjeYq-X3z8dv6pub65vDp_f90EQXhp2jYI3rmWd14DZbz10nPhlRDKOGI4Y1y1fVA-KCO5pEC1oL13LjgjHHP8FL059O7T_GOBXOwYc4BhcBPMS7aKc6XbtqWVPPsvSTVXnFDOSEVf_4XezUuqX5dtXYgxrdTaRw9QSHPOCXq7T3F06d5SYleL9mDRVot2tWhlzbw6Fi9-hO4hcdRWAXYAcr2abiE9vPzv1j8I_Khu</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Schneider, Juliane M.E.</creator><creator>Brücher, Björn L.D.M.</creator><creator>Küper, Markus</creator><creator>Saemann, Kathrin</creator><creator>Königsrainer, Alfred</creator><creator>Schneider, Joachim H.</creator><general>Springer New York</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Multichannel Intraluminal Impedance Measurement of Gastroesophageal Reflux in Patients with Different Stages of Morbid Obesity</title><author>Schneider, Juliane M.E. ; Brücher, Björn L.D.M. ; Küper, Markus ; Saemann, Kathrin ; Königsrainer, Alfred ; Schneider, Joachim H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-55c43da53db8e1235b6b34b74479a09322375fc7bc796361e1841fbaaca94a2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Body Mass Index</topic><topic>Esophageal pH Monitoring</topic><topic>Esophageal Spasm, Diffuse - physiopathology</topic><topic>Esophageal Sphincter, Lower - physiopathology</topic><topic>Female</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - epidemiology</topic><topic>Gastroesophageal Reflux - pathology</topic><topic>Gastroesophageal Reflux - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Manometry - methods</topic><topic>Measurement</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - epidemiology</topic><topic>Obesity, Morbid - pathology</topic><topic>Obesity, Morbid - physiopathology</topic><topic>Postprandial Period</topic><topic>Posture</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Research Article</topic><topic>Risk factors</topic><topic>Severity of Illness Index</topic><topic>Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schneider, Juliane M.E.</creatorcontrib><creatorcontrib>Brücher, Björn L.D.M.</creatorcontrib><creatorcontrib>Küper, Markus</creatorcontrib><creatorcontrib>Saemann, Kathrin</creatorcontrib><creatorcontrib>Königsrainer, Alfred</creatorcontrib><creatorcontrib>Schneider, Joachim H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schneider, Juliane M.E.</au><au>Brücher, Björn L.D.M.</au><au>Küper, Markus</au><au>Saemann, Kathrin</au><au>Königsrainer, Alfred</au><au>Schneider, Joachim H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multichannel Intraluminal Impedance Measurement of Gastroesophageal Reflux in Patients with Different Stages of Morbid Obesity</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>19</volume><issue>11</issue><spage>1522</spage><epage>1529</epage><pages>1522-1529</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
Obesity is now one of the world’s major chronic diseases. The etiology of the severe comorbid conditions associated with morbid obesity is not fully understood, and in particular the relationship between gastroesophageal reflux and obesity.
Methods
Sixty-seven patients were enrolled in this prospective study. Patients and control individuals were divided into four subgroups according to their body mass index (BMI). Esophageal motility was assessed using a conventional water-perfused esophageal manometry catheter, and 24-h pH-metry was carried out using multichannel intraluminal impedance equipment.
Results
In the group with the highest BMI (>50), contraction amplitudes in the middle and distal esophagus were significantly higher in comparison both with the control group and groups with a lower BMI (
P
< 0.05). Lower esophageal sphincter pressure was reduced in the majority of patients with morbid obesity and differed significantly from the control group (
P
< 0.001). Significant differences between the control group and the patient groups were also observed on 24-h pH-metry (
P
< 0.05). The 24-h impedance measurements distinguished between acid and nonacid status and between the upright and recumbent positions. The total number of reflux episodes differed significantly between the control and patient groups and between groups III and IV, with lower and higher BMI values (
P
< 0.008 and
P
< 0.05, respectively).
Conclusions
The impedance data obtained in this study confirm that patients with morbid obesity are at risk of developing gastroesophageal reflux disease. However, there is no evidence of a direct correlation between the severity of reflux and the extent of obesity.</abstract><cop>New York</cop><pub>Springer New York</pub><pmid>18648896</pmid><doi>10.1007/s11695-008-9624-6</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0960-8923 |
| ispartof | Obesity surgery, 2009-11, Vol.19 (11), p.1522-1529 |
| issn | 0960-8923 1708-0428 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Body Mass Index Esophageal pH Monitoring Esophageal Spasm, Diffuse - physiopathology Esophageal Sphincter, Lower - physiopathology Female Gastroesophageal reflux Gastroesophageal Reflux - epidemiology Gastroesophageal Reflux - pathology Gastroesophageal Reflux - physiopathology Humans Male Manometry - methods Measurement Medicine Medicine & Public Health Middle Aged Obesity Obesity, Morbid - epidemiology Obesity, Morbid - pathology Obesity, Morbid - physiopathology Postprandial Period Posture Prevalence Prospective Studies Research Article Risk factors Severity of Illness Index Surgery Young Adult |
| title | Multichannel Intraluminal Impedance Measurement of Gastroesophageal Reflux in Patients with Different Stages of Morbid Obesity |
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