Epidemiological study of hepatitis A, B and C in the largest Afro-Brazilian isolated community
This study was conducted to estimate the prevalence and molecular epidemiological features of viral hepatitis A, B and C in the Kalunga population, which represents the largest Afro-Brazilian isolated community. Among 878 individuals studied, the overall prevalence of anti-hepatitis A virus antibodi...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 2009-09, Vol.103 (9), p.899-905 |
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| creator | Matos, Márcia A.D. Reis, Nádia Rúbia S. Kozlowski, Aline G. Teles, Sheila A. Motta-Castro, Ana Rita C. Mello, Francisco C.A. Gomes, Selma A. Martins, Regina M.B. |
| description | This study was conducted to estimate the prevalence and molecular epidemiological features of viral hepatitis A, B and C in the
Kalunga population, which represents the largest Afro-Brazilian isolated community. Among 878 individuals studied, the overall prevalence of anti-hepatitis A virus antibodies was 80.9%, with a significant rise from 44.8% to near 100% between the first and fourth decade of life. Rates for hepatitis B surface antigen (HBsAg) and antibody to hepatitis B core antigen (anti-HBc) of 1.8% and 35.4%, respectively, were found. Increasing age, male gender, illiteracy and history of multiple sexual partners were associated with hepatitis B virus (HBV) infection. An occult HBV infection rate of 1.7% (5/295) was found among anti-HBc-positive individuals. HBV genotype A (subtype Aa) was dominant in this community. Only 5/878 individuals (0.6%) were positive for anti-hepatitis C virus (HCV). HCV RNA was detected in three of them, who were infected with genotype 1 (subtype 1a). These findings point out high, intermediate and low endemicity for hepatitis A, B and C, respectively, in the
Kalunga community in Brazil. Circulation of HBV genotype A (subtype Aa) in this Afro-Brazilian isolated community indicates the introduction of this virus during the slave trade from Africa to Brazil. |
| doi_str_mv | 10.1016/j.trstmh.2009.01.013 |
| format | Article |
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Kalunga population, which represents the largest Afro-Brazilian isolated community. Among 878 individuals studied, the overall prevalence of anti-hepatitis A virus antibodies was 80.9%, with a significant rise from 44.8% to near 100% between the first and fourth decade of life. Rates for hepatitis B surface antigen (HBsAg) and antibody to hepatitis B core antigen (anti-HBc) of 1.8% and 35.4%, respectively, were found. Increasing age, male gender, illiteracy and history of multiple sexual partners were associated with hepatitis B virus (HBV) infection. An occult HBV infection rate of 1.7% (5/295) was found among anti-HBc-positive individuals. HBV genotype A (subtype Aa) was dominant in this community. Only 5/878 individuals (0.6%) were positive for anti-hepatitis C virus (HCV). HCV RNA was detected in three of them, who were infected with genotype 1 (subtype 1a). These findings point out high, intermediate and low endemicity for hepatitis A, B and C, respectively, in the
Kalunga community in Brazil. Circulation of HBV genotype A (subtype Aa) in this Afro-Brazilian isolated community indicates the introduction of this virus during the slave trade from Africa to Brazil.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1016/j.trstmh.2009.01.013</identifier><identifier>PMID: 19217131</identifier><identifier>CODEN: TRSTAZ</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Africa - ethnology ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Brazil ; Brazil - epidemiology ; Child ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; Female ; General aspects ; Genotype ; Hepatitis A - epidemiology ; Hepatitis A - ethnology ; Hepatitis A - immunology ; Hepatitis A virus ; Hepatitis Antibodies - blood ; Hepatitis B - epidemiology ; Hepatitis B - ethnology ; Hepatitis B - immunology ; Hepatitis B Core Antigens - immunology ; Hepatitis B Surface Antigens - blood ; Hepatitis B virus ; Hepatitis C - epidemiology ; Hepatitis C - ethnology ; Hepatitis C - immunology ; Hepatitis C virus ; Human viral diseases ; Humans ; Infant ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Prevalence ; Viral diseases ; Viral hepatitis ; Young Adult</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 2009-09, Vol.103 (9), p.899-905</ispartof><rights>2009 Royal Society of Tropical Medicine and Hygiene</rights><rights>Royal Society of Tropical Medicine and Hygiene 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-42b15511ceec591a828e1356ff311debd138f096a358dcb9d92cbf017502ea563</citedby><cites>FETCH-LOGICAL-c500t-42b15511ceec591a828e1356ff311debd138f096a358dcb9d92cbf017502ea563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21980428$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19217131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matos, Márcia A.D.</creatorcontrib><creatorcontrib>Reis, Nádia Rúbia S.</creatorcontrib><creatorcontrib>Kozlowski, Aline G.</creatorcontrib><creatorcontrib>Teles, Sheila A.</creatorcontrib><creatorcontrib>Motta-Castro, Ana Rita C.</creatorcontrib><creatorcontrib>Mello, Francisco C.A.</creatorcontrib><creatorcontrib>Gomes, Selma A.</creatorcontrib><creatorcontrib>Martins, Regina M.B.</creatorcontrib><title>Epidemiological study of hepatitis A, B and C in the largest Afro-Brazilian isolated community</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>This study was conducted to estimate the prevalence and molecular epidemiological features of viral hepatitis A, B and C in the
Kalunga population, which represents the largest Afro-Brazilian isolated community. Among 878 individuals studied, the overall prevalence of anti-hepatitis A virus antibodies was 80.9%, with a significant rise from 44.8% to near 100% between the first and fourth decade of life. Rates for hepatitis B surface antigen (HBsAg) and antibody to hepatitis B core antigen (anti-HBc) of 1.8% and 35.4%, respectively, were found. Increasing age, male gender, illiteracy and history of multiple sexual partners were associated with hepatitis B virus (HBV) infection. An occult HBV infection rate of 1.7% (5/295) was found among anti-HBc-positive individuals. HBV genotype A (subtype Aa) was dominant in this community. Only 5/878 individuals (0.6%) were positive for anti-hepatitis C virus (HCV). HCV RNA was detected in three of them, who were infected with genotype 1 (subtype 1a). These findings point out high, intermediate and low endemicity for hepatitis A, B and C, respectively, in the
Kalunga community in Brazil. Circulation of HBV genotype A (subtype Aa) in this Afro-Brazilian isolated community indicates the introduction of this virus during the slave trade from Africa to Brazil.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Africa - ethnology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Brazil - epidemiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>General aspects</subject><subject>Genotype</subject><subject>Hepatitis A - epidemiology</subject><subject>Hepatitis A - ethnology</subject><subject>Hepatitis A - immunology</subject><subject>Hepatitis A virus</subject><subject>Hepatitis Antibodies - blood</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - ethnology</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B Core Antigens - immunology</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis B virus</subject><subject>Hepatitis C - epidemiology</subject><subject>Hepatitis C - ethnology</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Young Adult</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVGL1DAUhYso7rj6D0Tyor7Y2dxk0qYvC7PD6ggrCqus-GDIJLc7GdumJqk4_no7dFjfFuHAffnOPZd7suw50DlQKM528xRiardzRmk1pzCKP8hmIEuZc0H5w2xGKRd5xSg_yZ7EuKOUCRDV4-wEKgYlcJhl3y97Z7F1vvG3zuiGxDTYPfE12WKvk0sukuUbckF0Z8mKuI6kLZJGh1uMiSzr4POLoP-4xumOuOgbndAS49t26FzaP80e1bqJ-Ow4T7Mvby8_r9b51cd371fLq9wISlO-YBsQAsAgGlGBlkwicFHUNQewuLHAZU2rQnMhrdlUtmJmU1MoBWWoRcFPs9fT3j74n8N4mmpdNNg0ukM_RFVyXkqxADmSr-4lGQBbFLIcwcUEmuBjDFirPrhWh70Cqg4NqJ2aGlCHBhSFUXy0vTjuHzYt2n-m48tH4OUR0HF8eB10Z1y84xhUki7Y4dCzifND_7_R-eRwMeHvO48OP1RR8lKo9ddv6pO8KT_crK_V9cifTzyOzfxyGFQ0DjuD1gU0SVnv7g_8C6MNxDM</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Matos, Márcia A.D.</creator><creator>Reis, Nádia Rúbia S.</creator><creator>Kozlowski, Aline G.</creator><creator>Teles, Sheila A.</creator><creator>Motta-Castro, Ana Rita C.</creator><creator>Mello, Francisco C.A.</creator><creator>Gomes, Selma A.</creator><creator>Martins, Regina M.B.</creator><general>Elsevier Ltd</general><general>Royal Society of Tropical Medicine and Hygiene</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Epidemiological study of hepatitis A, B and C in the largest Afro-Brazilian isolated community</title><author>Matos, Márcia A.D. ; Reis, Nádia Rúbia S. ; Kozlowski, Aline G. ; Teles, Sheila A. ; Motta-Castro, Ana Rita C. ; Mello, Francisco C.A. ; Gomes, Selma A. ; Martins, Regina M.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-42b15511ceec591a828e1356ff311debd138f096a358dcb9d92cbf017502ea563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Africa - ethnology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Brazil</topic><topic>Brazil - epidemiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>General aspects</topic><topic>Genotype</topic><topic>Hepatitis A - epidemiology</topic><topic>Hepatitis A - ethnology</topic><topic>Hepatitis A - immunology</topic><topic>Hepatitis A virus</topic><topic>Hepatitis Antibodies - blood</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - ethnology</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis B Core Antigens - immunology</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Hepatitis B virus</topic><topic>Hepatitis C - epidemiology</topic><topic>Hepatitis C - ethnology</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matos, Márcia A.D.</creatorcontrib><creatorcontrib>Reis, Nádia Rúbia S.</creatorcontrib><creatorcontrib>Kozlowski, Aline G.</creatorcontrib><creatorcontrib>Teles, Sheila A.</creatorcontrib><creatorcontrib>Motta-Castro, Ana Rita C.</creatorcontrib><creatorcontrib>Mello, Francisco C.A.</creatorcontrib><creatorcontrib>Gomes, Selma A.</creatorcontrib><creatorcontrib>Martins, Regina M.B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matos, Márcia A.D.</au><au>Reis, Nádia Rúbia S.</au><au>Kozlowski, Aline G.</au><au>Teles, Sheila A.</au><au>Motta-Castro, Ana Rita C.</au><au>Mello, Francisco C.A.</au><au>Gomes, Selma A.</au><au>Martins, Regina M.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiological study of hepatitis A, B and C in the largest Afro-Brazilian isolated community</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><stitle>Trans R Soc Trop Med Hyg</stitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>103</volume><issue>9</issue><spage>899</spage><epage>905</epage><pages>899-905</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><coden>TRSTAZ</coden><abstract>This study was conducted to estimate the prevalence and molecular epidemiological features of viral hepatitis A, B and C in the
Kalunga population, which represents the largest Afro-Brazilian isolated community. Among 878 individuals studied, the overall prevalence of anti-hepatitis A virus antibodies was 80.9%, with a significant rise from 44.8% to near 100% between the first and fourth decade of life. Rates for hepatitis B surface antigen (HBsAg) and antibody to hepatitis B core antigen (anti-HBc) of 1.8% and 35.4%, respectively, were found. Increasing age, male gender, illiteracy and history of multiple sexual partners were associated with hepatitis B virus (HBV) infection. An occult HBV infection rate of 1.7% (5/295) was found among anti-HBc-positive individuals. HBV genotype A (subtype Aa) was dominant in this community. Only 5/878 individuals (0.6%) were positive for anti-hepatitis C virus (HCV). HCV RNA was detected in three of them, who were infected with genotype 1 (subtype 1a). These findings point out high, intermediate and low endemicity for hepatitis A, B and C, respectively, in the
Kalunga community in Brazil. Circulation of HBV genotype A (subtype Aa) in this Afro-Brazilian isolated community indicates the introduction of this virus during the slave trade from Africa to Brazil.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>19217131</pmid><doi>10.1016/j.trstmh.2009.01.013</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Africa - ethnology Aged Aged, 80 and over Biological and medical sciences Brazil Brazil - epidemiology Child Child, Preschool Enzyme-Linked Immunosorbent Assay Female General aspects Genotype Hepatitis A - epidemiology Hepatitis A - ethnology Hepatitis A - immunology Hepatitis A virus Hepatitis Antibodies - blood Hepatitis B - epidemiology Hepatitis B - ethnology Hepatitis B - immunology Hepatitis B Core Antigens - immunology Hepatitis B Surface Antigens - blood Hepatitis B virus Hepatitis C - epidemiology Hepatitis C - ethnology Hepatitis C - immunology Hepatitis C virus Human viral diseases Humans Infant Infectious diseases Male Medical sciences Middle Aged Prevalence Viral diseases Viral hepatitis Young Adult |
| title | Epidemiological study of hepatitis A, B and C in the largest Afro-Brazilian isolated community |
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