MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo

Aurora A kinase is a serine/threonine protein kinase responsible for regulating several mitotic processes including centrosome separation, spindle assembly, and chromosome segregation. Small molecule inhibitors of Aurora A kinase are being pursued as novel anticancer agents, some of which have enter...

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Veröffentlicht in:	Molecular cancer research 2010-03, Vol.8 (3), p.373-384
Hauptverfasser:	Huck, Jessica J, Zhang, Mengkun, McDonald, Alice, Bowman, Doug, Hoar, Kara M, Stringer, Bradley, Ecsedy, Jeffery, Manfredi, Mark G, Hyer, Marc L
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Aurora Kinase A Aurora Kinases Benzazepines - pharmacology Benzazepines - therapeutic use beta-Galactosidase - drug effects beta-Galactosidase - metabolism Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Cell Line, Tumor Cell Size - drug effects Cellular Senescence - drug effects Cellular Senescence - physiology Cyclin-Dependent Kinase Inhibitor p21 - drug effects Cyclin-Dependent Kinase Inhibitor p21 - metabolism Drug Administration Schedule Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Female Humans Mice Mice, Nude Neoplasms, Experimental - drug therapy Neoplasms, Experimental - enzymology Neoplasms, Experimental - physiopathology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Retinoblastoma Protein - drug effects Retinoblastoma Protein - metabolism Transplantation, Heterologous Tumor Suppressor Protein p53 - drug effects Tumor Suppressor Protein p53 - metabolism
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