Association of Interleukin-18 Gene Polymorphisms with Hepatitis B Virus Clearance
The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-γ-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nuc...
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| Veröffentlicht in: | Digestive diseases and sciences 2010-04, Vol.55 (4), p.1113-1119 |
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| creator | Cheong, Jae Youn Cho, Sung Won Oh, Bermseok Kimm, Kuchan Lee, Kee Myung Shin, Sung Jae Lee, Jung A Park, Byung Lae Cheong, Hyun Sub Shin, Hyoung Doo Cho, Bo Young Kim, Jin Hong |
| description | The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-γ-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean subjects were enrolled in the study and divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions −667G>T, −148G>C, +8925C>G, and +13925A>C. We observed that the subjects bearing the IL-18 −148C allele [odds ratio (OR), 0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; P = 0.01) were significantly associated with HBV clearance in a recessive model. This study indicates that the −148C, +8925G, and +13925C alleles of the IL-18 gene are likely associated with HBV clearance in a Korean population. |
| doi_str_mv | 10.1007/s10620-009-0819-z |
| format | Article |
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Interleukin-18 (IL-18) was originally discovered as an interferon-γ-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean subjects were enrolled in the study and divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions −667G>T, −148G>C, +8925C>G, and +13925A>C. We observed that the subjects bearing the IL-18 −148C allele [odds ratio (OR), 0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; P = 0.01) were significantly associated with HBV clearance in a recessive model. This study indicates that the −148C, +8925G, and +13925C alleles of the IL-18 gene are likely associated with HBV clearance in a Korean population.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-009-0819-z</identifier><identifier>PMID: 19466545</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Adult ; Aged ; Alleles ; Analysis ; B cells ; Biochemistry ; Biological and medical sciences ; Biological response modifiers ; Carrier State - immunology ; Chromosome Mapping ; Confidence Intervals ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Genes ; Genes, Recessive ; Genetic aspects ; Genotype ; Haplotypes - genetics ; Health aspects ; Hepatitis B ; Hepatitis B - genetics ; Hepatitis B - immunology ; Hepatitis B virus ; Hepatology ; Human viral diseases ; Humans ; Immune response ; Immunogenetic Phenomena ; Infection ; Infectious diseases ; Interferon ; Interleukin-18 - genetics ; Interleukins ; Linkage Disequilibrium - genetics ; Linkage Disequilibrium - immunology ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Odds Ratio ; Oncology ; Original Article ; Polymorphism, Single Nucleotide - genetics ; Prospective Studies ; Remission, Spontaneous ; Republic of Korea ; Single nucleotide polymorphisms ; T-Lymphocytes, Cytotoxic - immunology ; Transplant Surgery ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Viral diseases ; Viral hepatitis ; Young Adult</subject><ispartof>Digestive diseases and sciences, 2010-04, Vol.55 (4), p.1113-1119</ispartof><rights>Springer Science+Business Media, LLC 2009</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Springer</rights><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-ec12eb2cddc19b75cbca40cd0f557c274b7055bcec85ba6834bc62e501a852ac3</citedby><cites>FETCH-LOGICAL-c491t-ec12eb2cddc19b75cbca40cd0f557c274b7055bcec85ba6834bc62e501a852ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-009-0819-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-009-0819-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22598140$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19466545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheong, Jae Youn</creatorcontrib><creatorcontrib>Cho, Sung Won</creatorcontrib><creatorcontrib>Oh, Bermseok</creatorcontrib><creatorcontrib>Kimm, Kuchan</creatorcontrib><creatorcontrib>Lee, Kee Myung</creatorcontrib><creatorcontrib>Shin, Sung Jae</creatorcontrib><creatorcontrib>Lee, Jung A</creatorcontrib><creatorcontrib>Park, Byung Lae</creatorcontrib><creatorcontrib>Cheong, Hyun Sub</creatorcontrib><creatorcontrib>Shin, Hyoung Doo</creatorcontrib><creatorcontrib>Cho, Bo Young</creatorcontrib><creatorcontrib>Kim, Jin Hong</creatorcontrib><title>Association of Interleukin-18 Gene Polymorphisms with Hepatitis B Virus Clearance</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-γ-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean subjects were enrolled in the study and divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions −667G>T, −148G>C, +8925C>G, and +13925A>C. We observed that the subjects bearing the IL-18 −148C allele [odds ratio (OR), 0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; P = 0.01) were significantly associated with HBV clearance in a recessive model. This study indicates that the −148C, +8925G, and +13925C alleles of the IL-18 gene are likely associated with HBV clearance in a Korean population.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Analysis</subject><subject>B cells</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biological response modifiers</subject><subject>Carrier State - immunology</subject><subject>Chromosome Mapping</subject><subject>Confidence Intervals</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Genes</subject><subject>Genes, Recessive</subject><subject>Genetic aspects</subject><subject>Genotype</subject><subject>Haplotypes - genetics</subject><subject>Health aspects</subject><subject>Hepatitis B</subject><subject>Hepatitis B - genetics</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B virus</subject><subject>Hepatology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunogenetic Phenomena</subject><subject>Infection</subject><subject>Infectious diseases</subject><subject>Interferon</subject><subject>Interleukin-18 - genetics</subject><subject>Interleukins</subject><subject>Linkage Disequilibrium - genetics</subject><subject>Linkage Disequilibrium - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Prospective Studies</subject><subject>Remission, Spontaneous</subject><subject>Republic of Korea</subject><subject>Single nucleotide polymorphisms</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Transplant Surgery</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Young Adult</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ks1u1DAUhS0EotOBB2ADEQixSvH1T5wsh1FpK1UCBGVrOc7N1CWJp3Yi1D49jjKiAiHkhS3f7xxf-5iQF0BPgFL1PgItGM0prXJaQpXfPyIrkIrnTBblY7KiUKQ1QHFEjmO8oQlUUDwlR1CJopBCrsiXTYzeOjM6P2S-zS6GEUOH0w835FBmZzhg9tl3d70P-2sX-5j9dON1do77JBldzD5k312YYrbt0AQzWHxGnrSmi_j8MK_J1cfTb9vz_PLT2cV2c5lbUcGYowWGNbNNY6GqlbS1NYLahrZSKsuUqBWVsrZoS1mbouSitgVDScGUkhnL1-Td4rsP_nbCOOreRYtdZwb0U9SKc1UKmpRr8vov8sZPYUjNaQaCC66AJejNAu1Mh9oNrR-DsbOl3qR6xTmvZquTf1BpNNg76wdsXdr_QwCLwAYfY8BW74PrTbjTQPUcol5C1CkbPYeo75Pm5aHfqe6xeVAcUkvA2wNgojVdO7-7i785xmRVgqCJYwsXU2nYYXi4-P9Of7WIWuO12YVkfPWVUeAUSkjfR_FfKvi73Q</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Cheong, Jae Youn</creator><creator>Cho, Sung Won</creator><creator>Oh, Bermseok</creator><creator>Kimm, Kuchan</creator><creator>Lee, Kee Myung</creator><creator>Shin, Sung Jae</creator><creator>Lee, Jung A</creator><creator>Park, Byung Lae</creator><creator>Cheong, Hyun Sub</creator><creator>Shin, Hyoung Doo</creator><creator>Cho, Bo Young</creator><creator>Kim, Jin Hong</creator><general>Boston : Springer US</general><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20100401</creationdate><title>Association of Interleukin-18 Gene Polymorphisms with Hepatitis B Virus Clearance</title><author>Cheong, Jae Youn ; Cho, Sung Won ; Oh, Bermseok ; Kimm, Kuchan ; Lee, Kee Myung ; Shin, Sung Jae ; Lee, Jung A ; Park, Byung Lae ; Cheong, Hyun Sub ; Shin, Hyoung Doo ; Cho, Bo Young ; Kim, Jin Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-ec12eb2cddc19b75cbca40cd0f557c274b7055bcec85ba6834bc62e501a852ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Analysis</topic><topic>B cells</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biological response modifiers</topic><topic>Carrier State - immunology</topic><topic>Chromosome Mapping</topic><topic>Confidence Intervals</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology</topic><topic>Genes</topic><topic>Genes, Recessive</topic><topic>Genetic aspects</topic><topic>Genotype</topic><topic>Haplotypes - genetics</topic><topic>Health aspects</topic><topic>Hepatitis B</topic><topic>Hepatitis B - genetics</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis B virus</topic><topic>Hepatology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunogenetic Phenomena</topic><topic>Infection</topic><topic>Infectious diseases</topic><topic>Interferon</topic><topic>Interleukin-18 - genetics</topic><topic>Interleukins</topic><topic>Linkage Disequilibrium - genetics</topic><topic>Linkage Disequilibrium - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Prospective Studies</topic><topic>Remission, Spontaneous</topic><topic>Republic of Korea</topic><topic>Single nucleotide polymorphisms</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Transplant Surgery</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheong, Jae Youn</creatorcontrib><creatorcontrib>Cho, Sung Won</creatorcontrib><creatorcontrib>Oh, Bermseok</creatorcontrib><creatorcontrib>Kimm, Kuchan</creatorcontrib><creatorcontrib>Lee, Kee Myung</creatorcontrib><creatorcontrib>Shin, Sung Jae</creatorcontrib><creatorcontrib>Lee, Jung A</creatorcontrib><creatorcontrib>Park, Byung Lae</creatorcontrib><creatorcontrib>Cheong, Hyun Sub</creatorcontrib><creatorcontrib>Shin, Hyoung Doo</creatorcontrib><creatorcontrib>Cho, Bo Young</creatorcontrib><creatorcontrib>Kim, Jin Hong</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheong, Jae Youn</au><au>Cho, Sung Won</au><au>Oh, Bermseok</au><au>Kimm, Kuchan</au><au>Lee, Kee Myung</au><au>Shin, Sung Jae</au><au>Lee, Jung A</au><au>Park, Byung Lae</au><au>Cheong, Hyun Sub</au><au>Shin, Hyoung Doo</au><au>Cho, Bo Young</au><au>Kim, Jin Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Interleukin-18 Gene Polymorphisms with Hepatitis B Virus Clearance</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>55</volume><issue>4</issue><spage>1113</spage><epage>1119</epage><pages>1113-1119</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-γ-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean subjects were enrolled in the study and divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions −667G>T, −148G>C, +8925C>G, and +13925A>C. We observed that the subjects bearing the IL-18 −148C allele [odds ratio (OR), 0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; P = 0.01) were significantly associated with HBV clearance in a recessive model. This study indicates that the −148C, +8925G, and +13925C alleles of the IL-18 gene are likely associated with HBV clearance in a Korean population.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>19466545</pmid><doi>10.1007/s10620-009-0819-z</doi><tpages>7</tpages></addata></record> |
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| ispartof | Digestive diseases and sciences, 2010-04, Vol.55 (4), p.1113-1119 |
| issn | 0163-2116 1573-2568 |
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| subjects | Adult Aged Alleles Analysis B cells Biochemistry Biological and medical sciences Biological response modifiers Carrier State - immunology Chromosome Mapping Confidence Intervals Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology Genes Genes, Recessive Genetic aspects Genotype Haplotypes - genetics Health aspects Hepatitis B Hepatitis B - genetics Hepatitis B - immunology Hepatitis B virus Hepatology Human viral diseases Humans Immune response Immunogenetic Phenomena Infection Infectious diseases Interferon Interleukin-18 - genetics Interleukins Linkage Disequilibrium - genetics Linkage Disequilibrium - immunology Male Medical sciences Medicine Medicine & Public Health Middle Aged Odds Ratio Oncology Original Article Polymorphism, Single Nucleotide - genetics Prospective Studies Remission, Spontaneous Republic of Korea Single nucleotide polymorphisms T-Lymphocytes, Cytotoxic - immunology Transplant Surgery Vertebrates: anatomy and physiology, studies on body, several organs or systems Viral diseases Viral hepatitis Young Adult |
| title | Association of Interleukin-18 Gene Polymorphisms with Hepatitis B Virus Clearance |
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