Regulation of Hypoxia-Inducible Genes by PGC-1α

Atmospheric oxygen appeared approximately 2.3 billion years ago and sustains most complex life on earth. As mitochondria evolved to harness the energy in oxygen, systems developed to sense and respond to local oxygen concentrations and metabolic conditions. For more than a decade, research has focus...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2010-04, Vol.30 (4), p.662-666
Hauptverfasser:	Shoag, Jonathan, Arany, Zolt
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Vessels - metabolism Blood Vessels - physiopathology Cell Hypoxia Gene Expression Regulation Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Humans Hypoxia-Inducible Factor 1 - genetics Hypoxia-Inducible Factor 1 - metabolism Ischemia - genetics Ischemia - metabolism Ischemia - physiopathology Mice Mitochondria - metabolism Neovascularization, Physiologic - genetics Oxygen - metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Reactive Oxygen Species - metabolism Signal Transduction - genetics Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation
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