Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide

Two forms of cyclooxygenase are known to be present in eukaryotic organisms: a cyclooxygenase (COX-1) first purified from ram seminal vesicles encoded by a 2.8-kilobase mRNA, and a newly discovered mitogen-inducible cyclooxygenase (COX-2) encoded by a 4-kilobase mRNA. Expression of these two forms o...

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Veröffentlicht in:	The Journal of biological chemistry 1992-12, Vol.267 (36), p.25934-25938
Hauptverfasser:	LEE, S. H, SOYOOLA, E, CHANMUGAM, P, HART, S, SUN, W, HUA ZHONG, LIOU, S, SIMMONS, D, HWANG, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Aspirin - pharmacology Base Sequence Biological and medical sciences Blotting, Western Cycloheximide - pharmacology Dactinomycin - pharmacology Dexamethasone - pharmacology Dinoprostone - metabolism Enzyme Induction Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Glyceraldehyde-3-Phosphate Dehydrogenases - biosynthesis Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Isoenzymes - biosynthesis Isoenzymes - genetics Isoenzymes - isolation & purification Kinetics Lipopolysaccharides - pharmacology Macrophages, Alveolar - drug effects Macrophages, Alveolar - enzymology Mitogens - pharmacology Molecular Sequence Data Oligodeoxyribonucleotides Oligonucleotides, Antisense Oxidoreductases Polymerase Chain Reaction - methods Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - isolation & purification Protein Biosynthesis Rats Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic
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