Influence of dl-Methionine and Other Substances on the Nephrotoxic Action of dl-Serine
dl -SERINE introduced either by stomach tube or by intraperitoneal injection causes severe kidney damage in young rats 1,2 . In view of the probable interaction of serine and methionine in the rat 3,4 , the influence of methionine on the serine effect was studied. Male rats weighing approximately 10...
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| Veröffentlicht in: | Nature (London) 1947-02, Vol.159 (4033), p.236-236 |
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| creator | WACHSTEIN, MAX |
| description | dl
-SERINE introduced either by stomach tube or by intraperitoneal injection causes severe kidney damage in young rats
1,2
. In view of the probable interaction of serine and methionine in the rat
3,4
, the influence of methionine on the serine effect was studied. Male rats weighing approximately 100 gm. were given 100 mgm.
dl
-serine by stomach tube and killed 24 hours later. Litter mates received the same amount of serine, and in addition
dl
-methionine in amounts varying from 100 to 600 mgm. subcutaneously in several injections preceding and following the administration of serine. 24 rats given serine alone showed extensive renal necrosis localized in the region of the corticomedullary junction (see Fig. 1). Of 39 animals given methionine in addition, 30 showed no lesions or only minute lesions (see Fig. 2). Only in two rats was no protective effect seen. |
| doi_str_mv | 10.1038/159236a0 |
| format | Article |
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-SERINE introduced either by stomach tube or by intraperitoneal injection causes severe kidney damage in young rats
1,2
. In view of the probable interaction of serine and methionine in the rat
3,4
, the influence of methionine on the serine effect was studied. Male rats weighing approximately 100 gm. were given 100 mgm.
dl
-serine by stomach tube and killed 24 hours later. Litter mates received the same amount of serine, and in addition
dl
-methionine in amounts varying from 100 to 600 mgm. subcutaneously in several injections preceding and following the administration of serine. 24 rats given serine alone showed extensive renal necrosis localized in the region of the corticomedullary junction (see Fig. 1). Of 39 animals given methionine in addition, 30 showed no lesions or only minute lesions (see Fig. 2). Only in two rats was no protective effect seen.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/159236a0</identifier><identifier>PMID: 20285663</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acids ; Dietary Proteins ; Humanities and Social Sciences ; Kidney - pathology ; letter ; Methionine - pharmacology ; multidisciplinary ; Old Medline ; Science ; Science (multidisciplinary) ; Serine - toxicity</subject><ispartof>Nature (London), 1947-02, Vol.159 (4033), p.236-236</ispartof><rights>Springer Nature Limited 1947</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-7798da272b0d82288a62f2b20bb4efedec73ee4f2405defac8eed699091b9c543</citedby><cites>FETCH-LOGICAL-c350t-7798da272b0d82288a62f2b20bb4efedec73ee4f2405defac8eed699091b9c543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/159236a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/159236a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20285663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WACHSTEIN, MAX</creatorcontrib><title>Influence of dl-Methionine and Other Substances on the Nephrotoxic Action of dl-Serine</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>dl
-SERINE introduced either by stomach tube or by intraperitoneal injection causes severe kidney damage in young rats
1,2
. In view of the probable interaction of serine and methionine in the rat
3,4
, the influence of methionine on the serine effect was studied. Male rats weighing approximately 100 gm. were given 100 mgm.
dl
-serine by stomach tube and killed 24 hours later. Litter mates received the same amount of serine, and in addition
dl
-methionine in amounts varying from 100 to 600 mgm. subcutaneously in several injections preceding and following the administration of serine. 24 rats given serine alone showed extensive renal necrosis localized in the region of the corticomedullary junction (see Fig. 1). Of 39 animals given methionine in addition, 30 showed no lesions or only minute lesions (see Fig. 2). Only in two rats was no protective effect seen.</description><subject>Amino Acids</subject><subject>Dietary Proteins</subject><subject>Humanities and Social Sciences</subject><subject>Kidney - pathology</subject><subject>letter</subject><subject>Methionine - pharmacology</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Serine - toxicity</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1947</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE9LAzEUxIMotlbBTyC5qYfVbLKbZI9F_AfVHqpel2zyYrdsk5rsgn57I61ePA28-c3AG4ROc3KVEyav87KijCuyh8Z5IXhWcCn20ZgQKjMiGR-hoxhXhJAyF8UhGtFklJyzMXp7dLYbwGnA3mLTZU_QL1vvWgdYOYPn_RICXgxN7FWCIvYOpxN-hs0y-N5_thpPdZ8Su_wCQsoeowOruggnO52g17vbl5uHbDa_f7yZzjLNStJnQlTSKCpoQ4ykVErFqaUNJU1TgAUDWjCAwtKClAas0hLA8KoiVd5UuizYBJ1vezfBfwwQ-3rdRg1dpxz4IdaCMSGoSDJBF1tSBx9jAFtvQrtW4avOSf0zYv07YkLPdqVDswbzB_6uloDLLRCT5d4h1Cs_BJce_V_2DcAReWQ</recordid><startdate>19470215</startdate><enddate>19470215</enddate><creator>WACHSTEIN, MAX</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19470215</creationdate><title>Influence of dl-Methionine and Other Substances on the Nephrotoxic Action of dl-Serine</title><author>WACHSTEIN, MAX</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-7798da272b0d82288a62f2b20bb4efedec73ee4f2405defac8eed699091b9c543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1947</creationdate><topic>Amino Acids</topic><topic>Dietary Proteins</topic><topic>Humanities and Social Sciences</topic><topic>Kidney - pathology</topic><topic>letter</topic><topic>Methionine - pharmacology</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Serine - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WACHSTEIN, MAX</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WACHSTEIN, MAX</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of dl-Methionine and Other Substances on the Nephrotoxic Action of dl-Serine</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1947-02-15</date><risdate>1947</risdate><volume>159</volume><issue>4033</issue><spage>236</spage><epage>236</epage><pages>236-236</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>dl
-SERINE introduced either by stomach tube or by intraperitoneal injection causes severe kidney damage in young rats
1,2
. In view of the probable interaction of serine and methionine in the rat
3,4
, the influence of methionine on the serine effect was studied. Male rats weighing approximately 100 gm. were given 100 mgm.
dl
-serine by stomach tube and killed 24 hours later. Litter mates received the same amount of serine, and in addition
dl
-methionine in amounts varying from 100 to 600 mgm. subcutaneously in several injections preceding and following the administration of serine. 24 rats given serine alone showed extensive renal necrosis localized in the region of the corticomedullary junction (see Fig. 1). Of 39 animals given methionine in addition, 30 showed no lesions or only minute lesions (see Fig. 2). Only in two rats was no protective effect seen.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20285663</pmid><doi>10.1038/159236a0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Amino Acids Dietary Proteins Humanities and Social Sciences Kidney - pathology letter Methionine - pharmacology multidisciplinary Old Medline Science Science (multidisciplinary) Serine - toxicity |
| title | Influence of dl-Methionine and Other Substances on the Nephrotoxic Action of dl-Serine |
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