Rheumatic fever-associated Streptococcus pyogenes isolates aggregate collagen

Acute rheumatic fever is a serious autoimmune sequel of Streptococcus pyogenes infection. This study shows that serotype M3 and M18 S. pyogenes isolated during outbreaks of rheumatic fever have the unique capability to bind and aggregate human basement membrane collagen type IV. M3 protein is identi...

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Veröffentlicht in:	The Journal of clinical investigation 2003-06, Vol.111 (12), p.1905-1912
Hauptverfasser:	Dinkla, Katrin, Rohde, Manfred, Jansen, Wouter T M, Kaplan, Edward L, Chhatwal, Gursharan S, Talay, Susanne R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial Autoantibodies - blood Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Base Sequence Biomedical research Carrier Proteins - genetics Carrier Proteins - immunology Case-Control Studies Collagen Type IV - immunology Collagen Type IV - ultrastructure DNA, Bacterial - genetics Female Humans Immunization In Vitro Techniques Mice Mice, Inbred BALB C Microscopy, Electron, Scanning Recombinant Proteins - genetics Recombinant Proteins - immunology Rheumatic Fever - immunology Rheumatic Fever - microbiology Streptococcus pyogenes - genetics Streptococcus pyogenes - immunology Streptococcus pyogenes - pathogenicity
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