Role of L-type calcium channels in pacing-induced short-term and long-term cardiac memory in canine heart

We tested the hypothesis that ICa,L is important to the development of cardiac memory. The effects of L-type Ca2+ channel blockade and beta-blockade were tested on acutely anesthetized and on chronically instrumented, conscious dogs. Short-term memory (STM) was induced by 2 hours of ventricular paci...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-06, Vol.107 (22), p.2844-2849
Hauptverfasser:	PLOTNIKOV, Alexei N, HANGANG YU, ROSEN, Michael R, GELLER, J. Christoph, GAINULLIN, Ravil Z, CHANDRA, Parag, PATBERG, Kornelis W, FRIEZEMA, Steven, DANILO, Peter JR, COHEN, Ira S, FEINMARK, Steven J
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals Anti-Arrhythmia Agents - pharmacology Biological and medical sciences Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - physiology Cardiac Pacing, Artificial Cells, Cultured Dogs Electrocardiography - drug effects Electrophysiologic Techniques, Cardiac Female Fundamental and applied biological sciences. Psychology Heart Heart - drug effects Heart - physiology Heart Conduction System - physiology Heart Ventricles - drug effects In Vitro Techniques Male Microelectrodes Myocytes, Cardiac - drug effects Myocytes, Cardiac - physiology Nifedipine - pharmacology Patch-Clamp Techniques Propranolol - pharmacology Ventricular Function Vertebrates: cardiovascular system
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