Beneficial effects of Waon therapy on patients with chronic heart failure: Results of a prospective multicenter study

Summary Background We conducted a prospective multicenter case–control study to confirm the clinical efficacy and safety of Waon therapy on chronic heart failure (CHF). Methods Patients ( n = 188) with CHF were treated with standard therapy for at least 1 week, and then were randomized to Waon thera...

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Veröffentlicht in:Journal of cardiology 2008-10, Vol.52 (2), p.79-85
Hauptverfasser: Miyata, Masaaki, MD, FJCC, Kihara, Takashi, MD, Kubozono, Takuro, MD, Ikeda, Yoshiyuki, MD, Shinsato, Takuro, MD, Izumi, Toru, MD, FJCC, Matsuzaki, Masunori, MD, FJCC, Yamaguchi, Tetsu, MD, FJCC, Kasanuki, Hiroshi, MD, FJCC, Daida, Hiroyuki, MD, FJCC, Nagayama, Masatoshi, MD, Nishigami, Kazuhiro, MD, Hirata, Kumiko, MD, Kihara, Koichi, MD, Tei, Chuwa, MD, FJCC
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container_end_page 85
container_issue 2
container_start_page 79
container_title Journal of cardiology
container_volume 52
creator Miyata, Masaaki, MD, FJCC
Kihara, Takashi, MD
Kubozono, Takuro, MD
Ikeda, Yoshiyuki, MD
Shinsato, Takuro, MD
Izumi, Toru, MD, FJCC
Matsuzaki, Masunori, MD, FJCC
Yamaguchi, Tetsu, MD, FJCC
Kasanuki, Hiroshi, MD, FJCC
Daida, Hiroyuki, MD, FJCC
Nagayama, Masatoshi, MD
Nishigami, Kazuhiro, MD
Hirata, Kumiko, MD
Kihara, Koichi, MD
Tei, Chuwa, MD, FJCC
description Summary Background We conducted a prospective multicenter case–control study to confirm the clinical efficacy and safety of Waon therapy on chronic heart failure (CHF). Methods Patients ( n = 188) with CHF were treated with standard therapy for at least 1 week, and then were randomized to Waon therapy ( n = 112) or a control group ( n = 76). All patients continued conventional treatment for an additional 2 weeks. The Waon therapy group was treated daily with a far infrared-ray dry sauna at 60 °C for 15 min and then kept on bed rest with a blanket for 30 min for 2 weeks. Chest radiography, echocardiography, and plasma levels of brain natriuretic peptide (BNP) were measured before and 2 weeks after treatment. Results NYHA functional class significantly decreased after 2 weeks of treatment in both groups. Chest radiography also showed a significant decrease of the cardiothoracic ratio in both groups (Waon therapy: 57.2 ± 8.0% to 55.2 ± 8.0%, p < 0.0001; control: 57.0 ± 7.7% to 56.0 ± 7.1%, p < 0.05). Echocardiography demonstrated that left ventricular diastolic dimension (LVDd), left atrial dimension (LAD), and ejection fraction (EF) significantly improved in the Waon therapy group (LVDd: 60.6 ± 7.6 to 59.1 ± 8.4 mm, p < 0.0001; LAD: 45.4 ± 9.3 mm to 44.1 ± 9.4 mm, p < 0.05; EF: 31.6 ± 10.4% to 34.6 ± 10.6%, p < 0.0001), but not in the control group (LVDd: 58.4 ± 10.3 mm to 57.9 ± 10.4 mm; LAD: 46.3 ± 9.7 mm to 46.2 ± 10.1 mm; EF: 36.6 ± 14.1% to 37.3 ± 14.0%). The plasma concentration of BNP significantly decreased with Waon therapy, but not in the control group (Waon: 542 ± 508 pg/ml to 394 ± 410 pg/ml, p < 0.001; control: 440 ± 377 pg/ml to 358 ± 382 pg/ml). Conclusion Waon therapy is safe, improves clinical symptoms and cardiac function, and decreases cardiac size in CHF patients. Waon therapy is an innovative and promising therapy for patients with CHF.
doi_str_mv 10.1016/j.jjcc.2008.07.009
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Methods Patients ( n = 188) with CHF were treated with standard therapy for at least 1 week, and then were randomized to Waon therapy ( n = 112) or a control group ( n = 76). All patients continued conventional treatment for an additional 2 weeks. The Waon therapy group was treated daily with a far infrared-ray dry sauna at 60 °C for 15 min and then kept on bed rest with a blanket for 30 min for 2 weeks. Chest radiography, echocardiography, and plasma levels of brain natriuretic peptide (BNP) were measured before and 2 weeks after treatment. Results NYHA functional class significantly decreased after 2 weeks of treatment in both groups. Chest radiography also showed a significant decrease of the cardiothoracic ratio in both groups (Waon therapy: 57.2 ± 8.0% to 55.2 ± 8.0%, p < 0.0001; control: 57.0 ± 7.7% to 56.0 ± 7.1%, p < 0.05). Echocardiography demonstrated that left ventricular diastolic dimension (LVDd), left atrial dimension (LAD), and ejection fraction (EF) significantly improved in the Waon therapy group (LVDd: 60.6 ± 7.6 to 59.1 ± 8.4 mm, p < 0.0001; LAD: 45.4 ± 9.3 mm to 44.1 ± 9.4 mm, p < 0.05; EF: 31.6 ± 10.4% to 34.6 ± 10.6%, p < 0.0001), but not in the control group (LVDd: 58.4 ± 10.3 mm to 57.9 ± 10.4 mm; LAD: 46.3 ± 9.7 mm to 46.2 ± 10.1 mm; EF: 36.6 ± 14.1% to 37.3 ± 14.0%). The plasma concentration of BNP significantly decreased with Waon therapy, but not in the control group (Waon: 542 ± 508 pg/ml to 394 ± 410 pg/ml, p < 0.001; control: 440 ± 377 pg/ml to 358 ± 382 pg/ml). Conclusion Waon therapy is safe, improves clinical symptoms and cardiac function, and decreases cardiac size in CHF patients. Waon therapy is an innovative and promising therapy for patients with CHF.]]></description><identifier>ISSN: 0914-5087</identifier><identifier>EISSN: 1876-4738</identifier><identifier>DOI: 10.1016/j.jjcc.2008.07.009</identifier><identifier>PMID: 18922381</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Brain ; Cardiovascular ; Case-Control Studies ; Chronic Disease ; Echocardiography ; Female ; Heart failure ; Heart Failure - therapy ; Humans ; Hyperthermia, Induced - methods ; Male ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Natriuretic peptides ; Non-pharmacological therapy ; Prospective Studies ; Radiography, Thoracic ; Treatment ; Waon therapy</subject><ispartof>Journal of cardiology, 2008-10, Vol.52 (2), p.79-85</ispartof><rights>Japanese College of Cardiology</rights><rights>2008 Japanese College of Cardiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-3187f7c0251cce425ec015321e88108a04f4a70a39df0c2aba8ed81dcb4ad1543</citedby><cites>FETCH-LOGICAL-c507t-3187f7c0251cce425ec015321e88108a04f4a70a39df0c2aba8ed81dcb4ad1543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0914508708002001$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18922381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyata, Masaaki, MD, FJCC</creatorcontrib><creatorcontrib>Kihara, Takashi, MD</creatorcontrib><creatorcontrib>Kubozono, Takuro, MD</creatorcontrib><creatorcontrib>Ikeda, Yoshiyuki, MD</creatorcontrib><creatorcontrib>Shinsato, Takuro, MD</creatorcontrib><creatorcontrib>Izumi, Toru, MD, FJCC</creatorcontrib><creatorcontrib>Matsuzaki, Masunori, MD, FJCC</creatorcontrib><creatorcontrib>Yamaguchi, Tetsu, MD, FJCC</creatorcontrib><creatorcontrib>Kasanuki, Hiroshi, MD, FJCC</creatorcontrib><creatorcontrib>Daida, Hiroyuki, MD, FJCC</creatorcontrib><creatorcontrib>Nagayama, Masatoshi, MD</creatorcontrib><creatorcontrib>Nishigami, Kazuhiro, MD</creatorcontrib><creatorcontrib>Hirata, Kumiko, MD</creatorcontrib><creatorcontrib>Kihara, Koichi, MD</creatorcontrib><creatorcontrib>Tei, Chuwa, MD, FJCC</creatorcontrib><title>Beneficial effects of Waon therapy on patients with chronic heart failure: Results of a prospective multicenter study</title><title>Journal of cardiology</title><addtitle>J Cardiol</addtitle><description><![CDATA[Summary Background We conducted a prospective multicenter case–control study to confirm the clinical efficacy and safety of Waon therapy on chronic heart failure (CHF). Methods Patients ( n = 188) with CHF were treated with standard therapy for at least 1 week, and then were randomized to Waon therapy ( n = 112) or a control group ( n = 76). All patients continued conventional treatment for an additional 2 weeks. The Waon therapy group was treated daily with a far infrared-ray dry sauna at 60 °C for 15 min and then kept on bed rest with a blanket for 30 min for 2 weeks. Chest radiography, echocardiography, and plasma levels of brain natriuretic peptide (BNP) were measured before and 2 weeks after treatment. Results NYHA functional class significantly decreased after 2 weeks of treatment in both groups. Chest radiography also showed a significant decrease of the cardiothoracic ratio in both groups (Waon therapy: 57.2 ± 8.0% to 55.2 ± 8.0%, p < 0.0001; control: 57.0 ± 7.7% to 56.0 ± 7.1%, p < 0.05). Echocardiography demonstrated that left ventricular diastolic dimension (LVDd), left atrial dimension (LAD), and ejection fraction (EF) significantly improved in the Waon therapy group (LVDd: 60.6 ± 7.6 to 59.1 ± 8.4 mm, p < 0.0001; LAD: 45.4 ± 9.3 mm to 44.1 ± 9.4 mm, p < 0.05; EF: 31.6 ± 10.4% to 34.6 ± 10.6%, p < 0.0001), but not in the control group (LVDd: 58.4 ± 10.3 mm to 57.9 ± 10.4 mm; LAD: 46.3 ± 9.7 mm to 46.2 ± 10.1 mm; EF: 36.6 ± 14.1% to 37.3 ± 14.0%). The plasma concentration of BNP significantly decreased with Waon therapy, but not in the control group (Waon: 542 ± 508 pg/ml to 394 ± 410 pg/ml, p < 0.001; control: 440 ± 377 pg/ml to 358 ± 382 pg/ml). Conclusion Waon therapy is safe, improves clinical symptoms and cardiac function, and decreases cardiac size in CHF patients. Waon therapy is an innovative and promising therapy for patients with CHF.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain</subject><subject>Cardiovascular</subject><subject>Case-Control Studies</subject><subject>Chronic Disease</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart failure</subject><subject>Heart Failure - therapy</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Natriuretic peptides</subject><subject>Non-pharmacological therapy</subject><subject>Prospective Studies</subject><subject>Radiography, Thoracic</subject><subject>Treatment</subject><subject>Waon therapy</subject><issn>0914-5087</issn><issn>1876-4738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2r1DAQhoMonj2rf8ALyZ1XrZM03aQigh6OH3BA8AMvQ3Y6YVO7bU3aI_vvTdkFwQuvEpJ5H2aeYeyZgFKA2L3syq5DLCWAKUGXAM0DthFG7wqlK_OQbaARqqjB6Ct2nVIHsIPG7B6zK2EaKSsjNmx5RwP5gMH1nLwnnBMfPf_hxoHPB4puOvF8ndwcaMh_v8N84HiI4xCQH8jFmXsX-iXSK_6F0tKf845PcUxTxoV74sf8HDDnKfI0L-3pCXvkXZ_o6eXcsu_vb7_dfCzuPn_4dPP2rsAa9FxUeRivEWQtEEnJmhBEXUlBxggwDpRXToOrmtYDSrd3hlojWtwr14paVVv24szN3fxaKM32GBJS37uBxiVZXVVaKZ2ZWybPlZj7TpG8nWI4uniyAuxq23Z2tW1X2xa0zbZz6PkFv-yP1P6NXPTmgtfnAspD3geKNmH2iNSGmN3Ydgz_57_5J459yOJd_5NOlLpxiUPWZ4VN0oL9uu57XTcYgMwR1R8FFqdW</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Miyata, Masaaki, MD, FJCC</creator><creator>Kihara, Takashi, MD</creator><creator>Kubozono, Takuro, MD</creator><creator>Ikeda, Yoshiyuki, MD</creator><creator>Shinsato, Takuro, MD</creator><creator>Izumi, Toru, MD, FJCC</creator><creator>Matsuzaki, Masunori, MD, FJCC</creator><creator>Yamaguchi, Tetsu, MD, FJCC</creator><creator>Kasanuki, Hiroshi, MD, FJCC</creator><creator>Daida, Hiroyuki, MD, FJCC</creator><creator>Nagayama, Masatoshi, MD</creator><creator>Nishigami, Kazuhiro, MD</creator><creator>Hirata, Kumiko, MD</creator><creator>Kihara, Koichi, MD</creator><creator>Tei, Chuwa, MD, FJCC</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Beneficial effects of Waon therapy on patients with chronic heart failure: Results of a prospective multicenter study</title><author>Miyata, Masaaki, MD, FJCC ; 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Methods Patients ( n = 188) with CHF were treated with standard therapy for at least 1 week, and then were randomized to Waon therapy ( n = 112) or a control group ( n = 76). All patients continued conventional treatment for an additional 2 weeks. The Waon therapy group was treated daily with a far infrared-ray dry sauna at 60 °C for 15 min and then kept on bed rest with a blanket for 30 min for 2 weeks. Chest radiography, echocardiography, and plasma levels of brain natriuretic peptide (BNP) were measured before and 2 weeks after treatment. Results NYHA functional class significantly decreased after 2 weeks of treatment in both groups. Chest radiography also showed a significant decrease of the cardiothoracic ratio in both groups (Waon therapy: 57.2 ± 8.0% to 55.2 ± 8.0%, p < 0.0001; control: 57.0 ± 7.7% to 56.0 ± 7.1%, p < 0.05). Echocardiography demonstrated that left ventricular diastolic dimension (LVDd), left atrial dimension (LAD), and ejection fraction (EF) significantly improved in the Waon therapy group (LVDd: 60.6 ± 7.6 to 59.1 ± 8.4 mm, p < 0.0001; LAD: 45.4 ± 9.3 mm to 44.1 ± 9.4 mm, p < 0.05; EF: 31.6 ± 10.4% to 34.6 ± 10.6%, p < 0.0001), but not in the control group (LVDd: 58.4 ± 10.3 mm to 57.9 ± 10.4 mm; LAD: 46.3 ± 9.7 mm to 46.2 ± 10.1 mm; EF: 36.6 ± 14.1% to 37.3 ± 14.0%). The plasma concentration of BNP significantly decreased with Waon therapy, but not in the control group (Waon: 542 ± 508 pg/ml to 394 ± 410 pg/ml, p < 0.001; control: 440 ± 377 pg/ml to 358 ± 382 pg/ml). Conclusion Waon therapy is safe, improves clinical symptoms and cardiac function, and decreases cardiac size in CHF patients. Waon therapy is an innovative and promising therapy for patients with CHF.]]></abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>18922381</pmid><doi>10.1016/j.jjcc.2008.07.009</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Brain
Cardiovascular
Case-Control Studies
Chronic Disease
Echocardiography
Female
Heart failure
Heart Failure - therapy
Humans
Hyperthermia, Induced - methods
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Natriuretic peptides
Non-pharmacological therapy
Prospective Studies
Radiography, Thoracic
Treatment
Waon therapy
title Beneficial effects of Waon therapy on patients with chronic heart failure: Results of a prospective multicenter study
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