Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents

Novel matrix metalloproteinase (MMP) inhibitor radiotracers, ( S)-3-methyl-2-(2′,3′,4′-methoxybiphenyl-4-sulfonylamino)-butyric acid [ 11C]methyl ester ( 1a– c), ( S)-3-methyl-2-(2′,3′,4′-fluorobiphenyl-4-sulfonylamino)-butyric acid [ 11C]methyl ester ( 1d– f), and ( S)-3-methyl-2-(4′-nitrobiphenyl-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-07, Vol.13 (13), p.2217-2222
Hauptverfasser:	Fei, Xiangshu, Zheng, Qi-Huang, Liu, Xuan, Wang, Ji-Quan, Sun, Hui Bin, Mock, Bruce H., Stone, K.Lee, Miller, Kathy D., Sledge, George W., Hutchins, Gary D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biphenyl Compounds - chemical synthesis Biphenyl Compounds - pharmacology Chromatography, Thin Layer Contrast media. Radiopharmaceuticals Indicators and Reagents Isotope Labeling Magnetic Resonance Spectroscopy Mass Spectrometry Matrix Metalloproteinase 13 Matrix Metalloproteinase Inhibitors Medical sciences Molecular Conformation Neoplasms - diagnostic imaging Pharmacology. Drug treatments Protease Inhibitors - chemical synthesis Radiopharmaceuticals - chemical synthesis Sulfonamides - chemical synthesis Sulfonamides - pharmacology Tomography, Emission-Computed
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Novel matrix metalloproteinase (MMP) inhibitor radiotracers, ( S)-3-methyl-2-(2′,3′,4′-methoxybiphenyl-4-sulfonylamino)-butyric acid [ 11C]methyl ester ( 1a– c), ( S)-3-methyl-2-(2′,3′,4′-fluorobiphenyl-4-sulfonylamino)-butyric acid [ 11C]methyl ester ( 1d– f), and ( S)-3-methyl-2-(4′-nitrobiphenyl-4-sulfonylamino)-butyric acid [ 11C]methyl ester ( 1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as new potential positron emission tomography (PET) cancer imaging agents. Graphic
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(03)00382-2