A telomerase-dependent conditionally replicating adenovirus for selective treatment of cancer

The catalytic component of human telomerase reverse transcriptase (hTERT) is not expressed in most primary somatic human cells, whereas the majority of cancer cells reactivate telomerase by transcriptional up-regulation of hTERT. Several studies demonstrated that the hTERT promoter can be used to re...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-06, Vol.63 (12), p.3181-3188
Hauptverfasser:	WIRTH, Thomas, ZENDER, Lars, SCHULTE, Bernd, MUNDT, Bettina, PLENTZ, Ruben, RUDOLPH, Karl Lenhard, MANNS, Michael, KUBICKA, Stefan, KÜHNEL, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenovirus Adenovirus E1A Proteins - genetics Adenoviruses, Human - physiology Animals Biological and medical sciences Biological Therapy Carcinoma, Hepatocellular - secondary DNA-Binding Proteins Gene Expression Regulation, Neoplastic Gene Expression Regulation, Viral Genes, Reporter Green Fluorescent Proteins HeLa Cells - virology Hepatocytes - virology Humans Immunotherapy, Active Liver Neoplasms - pathology Luminescent Proteins - genetics Male Medical sciences Mice Mice, Nude Neoplasm Proteins - physiology Other treatments Promoter Regions, Genetic Recombinant Fusion Proteins - biosynthesis Specific Pathogen-Free Organisms TATA Box Telomerase - genetics Telomerase - physiology Transcription, Genetic Treatment. General aspects Tumor Cells, Cultured - virology Tumors Viral Vaccines - therapeutic use Virus Replication - physiology Xenograft Model Antitumor Assays
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