Strain Echocardiography and Wall Motion Score Index Predicts Final Infarct Size in Patients With Non―ST-Segment―Elevation Myocardial Infarction
Infarct size is a strong predictor of mortality and major adverse cardiovascular events after myocardial infarction. Acute reperfusion therapy limits infarct size and improves survival, but its use has been confined to patients with ST-segment-elevation myocardial infarction. The purpose of this stu...
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| Veröffentlicht in: | Circulation. Cardiovascular imaging 2010-03, Vol.3 (2), p.187-194 |
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| creator | EEK, Christian GRENNE, Bjørnar BRUNVAND, Harald AAKHUS, Svend ENDRESEN, Knut HOL, Per K SMITH, Hans-Jørgen SMISETH, Otto A EDVARDSEN, Thor SKULSTAD, Helge |
| description | Infarct size is a strong predictor of mortality and major adverse cardiovascular events after myocardial infarction. Acute reperfusion therapy limits infarct size and improves survival, but its use has been confined to patients with ST-segment-elevation myocardial infarction. The purpose of this study was to assess the relationship between echocardiographic parameters of left ventricular (LV) systolic function obtained before revascularization and final infarct size in patients with non-ST-segment-elevation myocardial infarction, as well as the ability of these parameters to identify patients with substantial infarction.
Sixty-one patients with non-ST-segment-elevation myocardial infarction were examined by echocardiography immediately before revascularization, 2.1+/-0.6 days after hospitalization. LV systolic function was assessed by ejection fraction, wall motion score index, and circumferential, longitudinal, and radial strain in a 16-segment LV model. Global strain represents average segmental strain values. Infarct size was assessed after 9+/-3 months by late-enhancement MRI, as a percentage of total LV myocardial volume. A good correlation was found between infarct size and wall motion score index (r=0.74, P1.30 accurately identified patients with substantial infarction (> or =12% of myocardium, n=13; area under the receiver operator curve, 0.95 and 0.92, respectively).
Echocardiographic parameters of LV systolic function correlate to infarct size in patients with non-ST-segment-elevation myocardial infarction. Global longitudinal strain and wall motion score index are both excellent parameters to identify patients with substantial myocardial infarction, who may benefit from urgent reperfusion therapy. |
| doi_str_mv | 10.1161/CIRCIMAGING.109.910521 |
| format | Article |
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Sixty-one patients with non-ST-segment-elevation myocardial infarction were examined by echocardiography immediately before revascularization, 2.1+/-0.6 days after hospitalization. LV systolic function was assessed by ejection fraction, wall motion score index, and circumferential, longitudinal, and radial strain in a 16-segment LV model. Global strain represents average segmental strain values. Infarct size was assessed after 9+/-3 months by late-enhancement MRI, as a percentage of total LV myocardial volume. A good correlation was found between infarct size and wall motion score index (r=0.74, P<0.001) and global longitudinal strain (r=0.68, P<0.001). Global longitudinal strain >-13.8% and wall motion score index >1.30 accurately identified patients with substantial infarction (> or =12% of myocardium, n=13; area under the receiver operator curve, 0.95 and 0.92, respectively).
Echocardiographic parameters of LV systolic function correlate to infarct size in patients with non-ST-segment-elevation myocardial infarction. Global longitudinal strain and wall motion score index are both excellent parameters to identify patients with substantial myocardial infarction, who may benefit from urgent reperfusion therapy.</description><identifier>ISSN: 1941-9651</identifier><identifier>EISSN: 1942-0080</identifier><identifier>DOI: 10.1161/CIRCIMAGING.109.910521</identifier><identifier>PMID: 20075142</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular system ; Chi-Square Distribution ; Coronary Angiography ; Coronary heart disease ; Echocardiography, Stress - methods ; Female ; Heart ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - drug therapy ; Myocardial Infarction - physiopathology ; Predictive Value of Tests ; Prospective Studies ; Regression Analysis ; Reproducibility of Results ; Risk Factors ; ROC Curve ; Systole ; Ultrasonic investigative techniques</subject><ispartof>Circulation. Cardiovascular imaging, 2010-03, Vol.3 (2), p.187-194</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-179f5e8c1135d03bb7f4ecc4402d88942d9bbdafe52948859188041558535fc13</citedby><cites>FETCH-LOGICAL-c388t-179f5e8c1135d03bb7f4ecc4402d88942d9bbdafe52948859188041558535fc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,3689,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22656459$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20075142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EEK, Christian</creatorcontrib><creatorcontrib>GRENNE, Bjørnar</creatorcontrib><creatorcontrib>BRUNVAND, Harald</creatorcontrib><creatorcontrib>AAKHUS, Svend</creatorcontrib><creatorcontrib>ENDRESEN, Knut</creatorcontrib><creatorcontrib>HOL, Per K</creatorcontrib><creatorcontrib>SMITH, Hans-Jørgen</creatorcontrib><creatorcontrib>SMISETH, Otto A</creatorcontrib><creatorcontrib>EDVARDSEN, Thor</creatorcontrib><creatorcontrib>SKULSTAD, Helge</creatorcontrib><title>Strain Echocardiography and Wall Motion Score Index Predicts Final Infarct Size in Patients With Non―ST-Segment―Elevation Myocardial Infarction</title><title>Circulation. Cardiovascular imaging</title><addtitle>Circ Cardiovasc Imaging</addtitle><description>Infarct size is a strong predictor of mortality and major adverse cardiovascular events after myocardial infarction. Acute reperfusion therapy limits infarct size and improves survival, but its use has been confined to patients with ST-segment-elevation myocardial infarction. The purpose of this study was to assess the relationship between echocardiographic parameters of left ventricular (LV) systolic function obtained before revascularization and final infarct size in patients with non-ST-segment-elevation myocardial infarction, as well as the ability of these parameters to identify patients with substantial infarction.
Sixty-one patients with non-ST-segment-elevation myocardial infarction were examined by echocardiography immediately before revascularization, 2.1+/-0.6 days after hospitalization. LV systolic function was assessed by ejection fraction, wall motion score index, and circumferential, longitudinal, and radial strain in a 16-segment LV model. Global strain represents average segmental strain values. Infarct size was assessed after 9+/-3 months by late-enhancement MRI, as a percentage of total LV myocardial volume. A good correlation was found between infarct size and wall motion score index (r=0.74, P<0.001) and global longitudinal strain (r=0.68, P<0.001). Global longitudinal strain >-13.8% and wall motion score index >1.30 accurately identified patients with substantial infarction (> or =12% of myocardium, n=13; area under the receiver operator curve, 0.95 and 0.92, respectively).
Echocardiographic parameters of LV systolic function correlate to infarct size in patients with non-ST-segment-elevation myocardial infarction. Global longitudinal strain and wall motion score index are both excellent parameters to identify patients with substantial myocardial infarction, who may benefit from urgent reperfusion therapy.</description><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Chi-Square Distribution</subject><subject>Coronary Angiography</subject><subject>Coronary heart disease</subject><subject>Echocardiography, Stress - methods</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Regression Analysis</subject><subject>Reproducibility of Results</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Systole</subject><subject>Ultrasonic investigative techniques</subject><issn>1941-9651</issn><issn>1942-0080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkcFO3DAQhq2qCCjlFZAvVU9ZPHGc2Ee0WraRWEANFcfIsR3WVdbe2lnU7anvUPUF-yQYdlt68vifb_6R5kfoDMgEoITzaf15Wi8u5vX1fAJETAQQlsMbdAyiyDNCOHn7UkMmSgZH6F2MXwkpKWH8EB3lhFQMivwY_WrGIK3DM7X0SgZt_UOQ6-UWS6fxvRwGvPCj9Q43ygeDa6fNd3wbjLZqjPjSOjkksZdBjbixPwxOXrdytMal9r0dl_jauz8_fzd3WWMeVklOn9lgHuWL62K72_rqktT36KCXQzSn-_cEfbmc3U0_ZVc383p6cZUpyvmYQSV6ZrgCoEwT2nVVXxilioLkmvN0Bi26TsvesFwUnDMBnJMCGOOMsl4BPUEfd77r4L9tTBzblY3KDIN0xm9iW1FaAQf2TJY7UgUfYzB9uw52JcO2BdI-59H-l0fSRLvLIw2e7VdsupXR_8b-BpCAD3tARiWHPkinbHzl8pKVBRP0CS5el1M</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>EEK, Christian</creator><creator>GRENNE, Bjørnar</creator><creator>BRUNVAND, Harald</creator><creator>AAKHUS, Svend</creator><creator>ENDRESEN, Knut</creator><creator>HOL, Per K</creator><creator>SMITH, Hans-Jørgen</creator><creator>SMISETH, Otto A</creator><creator>EDVARDSEN, Thor</creator><creator>SKULSTAD, Helge</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>Strain Echocardiography and Wall Motion Score Index Predicts Final Infarct Size in Patients With Non―ST-Segment―Elevation Myocardial Infarction</title><author>EEK, Christian ; GRENNE, Bjørnar ; BRUNVAND, Harald ; AAKHUS, Svend ; ENDRESEN, Knut ; HOL, Per K ; SMITH, Hans-Jørgen ; SMISETH, Otto A ; EDVARDSEN, Thor ; SKULSTAD, Helge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-179f5e8c1135d03bb7f4ecc4402d88942d9bbdafe52948859188041558535fc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Chi-Square Distribution</topic><topic>Coronary Angiography</topic><topic>Coronary heart disease</topic><topic>Echocardiography, Stress - methods</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Regression Analysis</topic><topic>Reproducibility of Results</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Systole</topic><topic>Ultrasonic investigative techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EEK, Christian</creatorcontrib><creatorcontrib>GRENNE, Bjørnar</creatorcontrib><creatorcontrib>BRUNVAND, Harald</creatorcontrib><creatorcontrib>AAKHUS, Svend</creatorcontrib><creatorcontrib>ENDRESEN, Knut</creatorcontrib><creatorcontrib>HOL, Per K</creatorcontrib><creatorcontrib>SMITH, Hans-Jørgen</creatorcontrib><creatorcontrib>SMISETH, Otto A</creatorcontrib><creatorcontrib>EDVARDSEN, Thor</creatorcontrib><creatorcontrib>SKULSTAD, Helge</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation. Cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EEK, Christian</au><au>GRENNE, Bjørnar</au><au>BRUNVAND, Harald</au><au>AAKHUS, Svend</au><au>ENDRESEN, Knut</au><au>HOL, Per K</au><au>SMITH, Hans-Jørgen</au><au>SMISETH, Otto A</au><au>EDVARDSEN, Thor</au><au>SKULSTAD, Helge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Strain Echocardiography and Wall Motion Score Index Predicts Final Infarct Size in Patients With Non―ST-Segment―Elevation Myocardial Infarction</atitle><jtitle>Circulation. Cardiovascular imaging</jtitle><addtitle>Circ Cardiovasc Imaging</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>3</volume><issue>2</issue><spage>187</spage><epage>194</epage><pages>187-194</pages><issn>1941-9651</issn><eissn>1942-0080</eissn><abstract>Infarct size is a strong predictor of mortality and major adverse cardiovascular events after myocardial infarction. Acute reperfusion therapy limits infarct size and improves survival, but its use has been confined to patients with ST-segment-elevation myocardial infarction. The purpose of this study was to assess the relationship between echocardiographic parameters of left ventricular (LV) systolic function obtained before revascularization and final infarct size in patients with non-ST-segment-elevation myocardial infarction, as well as the ability of these parameters to identify patients with substantial infarction.
Sixty-one patients with non-ST-segment-elevation myocardial infarction were examined by echocardiography immediately before revascularization, 2.1+/-0.6 days after hospitalization. LV systolic function was assessed by ejection fraction, wall motion score index, and circumferential, longitudinal, and radial strain in a 16-segment LV model. Global strain represents average segmental strain values. Infarct size was assessed after 9+/-3 months by late-enhancement MRI, as a percentage of total LV myocardial volume. A good correlation was found between infarct size and wall motion score index (r=0.74, P<0.001) and global longitudinal strain (r=0.68, P<0.001). Global longitudinal strain >-13.8% and wall motion score index >1.30 accurately identified patients with substantial infarction (> or =12% of myocardium, n=13; area under the receiver operator curve, 0.95 and 0.92, respectively).
Echocardiographic parameters of LV systolic function correlate to infarct size in patients with non-ST-segment-elevation myocardial infarction. Global longitudinal strain and wall motion score index are both excellent parameters to identify patients with substantial myocardial infarction, who may benefit from urgent reperfusion therapy.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>20075142</pmid><doi>10.1161/CIRCIMAGING.109.910521</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1941-9651 |
| ispartof | Circulation. Cardiovascular imaging, 2010-03, Vol.3 (2), p.187-194 |
| issn | 1941-9651 1942-0080 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Cardiology. Vascular system Cardiovascular system Chi-Square Distribution Coronary Angiography Coronary heart disease Echocardiography, Stress - methods Female Heart Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Myocardial Infarction - diagnostic imaging Myocardial Infarction - drug therapy Myocardial Infarction - physiopathology Predictive Value of Tests Prospective Studies Regression Analysis Reproducibility of Results Risk Factors ROC Curve Systole Ultrasonic investigative techniques |
| title | Strain Echocardiography and Wall Motion Score Index Predicts Final Infarct Size in Patients With Non―ST-Segment―Elevation Myocardial Infarction |
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