Strain Echocardiography and Wall Motion Score Index Predicts Final Infarct Size in Patients With Non―ST-Segment―Elevation Myocardial Infarction

Infarct size is a strong predictor of mortality and major adverse cardiovascular events after myocardial infarction. Acute reperfusion therapy limits infarct size and improves survival, but its use has been confined to patients with ST-segment-elevation myocardial infarction. The purpose of this stu...

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Veröffentlicht in:Circulation. Cardiovascular imaging 2010-03, Vol.3 (2), p.187-194
Hauptverfasser: EEK, Christian, GRENNE, Bjørnar, BRUNVAND, Harald, AAKHUS, Svend, ENDRESEN, Knut, HOL, Per K, SMITH, Hans-Jørgen, SMISETH, Otto A, EDVARDSEN, Thor, SKULSTAD, Helge
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container_end_page 194
container_issue 2
container_start_page 187
container_title Circulation. Cardiovascular imaging
container_volume 3
creator EEK, Christian
GRENNE, Bjørnar
BRUNVAND, Harald
AAKHUS, Svend
ENDRESEN, Knut
HOL, Per K
SMITH, Hans-Jørgen
SMISETH, Otto A
EDVARDSEN, Thor
SKULSTAD, Helge
description Infarct size is a strong predictor of mortality and major adverse cardiovascular events after myocardial infarction. Acute reperfusion therapy limits infarct size and improves survival, but its use has been confined to patients with ST-segment-elevation myocardial infarction. The purpose of this study was to assess the relationship between echocardiographic parameters of left ventricular (LV) systolic function obtained before revascularization and final infarct size in patients with non-ST-segment-elevation myocardial infarction, as well as the ability of these parameters to identify patients with substantial infarction. Sixty-one patients with non-ST-segment-elevation myocardial infarction were examined by echocardiography immediately before revascularization, 2.1+/-0.6 days after hospitalization. LV systolic function was assessed by ejection fraction, wall motion score index, and circumferential, longitudinal, and radial strain in a 16-segment LV model. Global strain represents average segmental strain values. Infarct size was assessed after 9+/-3 months by late-enhancement MRI, as a percentage of total LV myocardial volume. A good correlation was found between infarct size and wall motion score index (r=0.74, P1.30 accurately identified patients with substantial infarction (> or =12% of myocardium, n=13; area under the receiver operator curve, 0.95 and 0.92, respectively). Echocardiographic parameters of LV systolic function correlate to infarct size in patients with non-ST-segment-elevation myocardial infarction. Global longitudinal strain and wall motion score index are both excellent parameters to identify patients with substantial myocardial infarction, who may benefit from urgent reperfusion therapy.
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Acute reperfusion therapy limits infarct size and improves survival, but its use has been confined to patients with ST-segment-elevation myocardial infarction. The purpose of this study was to assess the relationship between echocardiographic parameters of left ventricular (LV) systolic function obtained before revascularization and final infarct size in patients with non-ST-segment-elevation myocardial infarction, as well as the ability of these parameters to identify patients with substantial infarction. Sixty-one patients with non-ST-segment-elevation myocardial infarction were examined by echocardiography immediately before revascularization, 2.1+/-0.6 days after hospitalization. LV systolic function was assessed by ejection fraction, wall motion score index, and circumferential, longitudinal, and radial strain in a 16-segment LV model. Global strain represents average segmental strain values. 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source MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals
subjects Biological and medical sciences
Cardiology. Vascular system
Cardiovascular system
Chi-Square Distribution
Coronary Angiography
Coronary heart disease
Echocardiography, Stress - methods
Female
Heart
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - drug therapy
Myocardial Infarction - physiopathology
Predictive Value of Tests
Prospective Studies
Regression Analysis
Reproducibility of Results
Risk Factors
ROC Curve
Systole
Ultrasonic investigative techniques
title Strain Echocardiography and Wall Motion Score Index Predicts Final Infarct Size in Patients With Non―ST-Segment―Elevation Myocardial Infarction
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