Reduction of advanced liver fibrosis by short‐term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats

There is no effective therapy for advanced liver fibrosis. Angiotensin type 1 (AT1) receptor blockers attenuate liver fibrogenesis, yet their efficacy in reversing advanced fibrosis is unknown. We investigated whether the specific delivery of an AT1 receptor blocker to activated hepatic stellate cel...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2010-03, Vol.51 (3), p.942-952
Hauptverfasser:	Moreno, Montserrat, Gonzalo, Teresa, Kok, Robbert J., Sancho‐Bru, Pau, van Beuge, Marike, Swart, Josine, Prakash, Jai, Temming, Kai, Fondevila, Constantino, Beljaars, Leonie, Lacombe, Marie, van der Hoeven, Paul, Arroyo, Vicente, Poelstra, Klaas, Brenner, David A., Ginès, Pere, Bataller, Ramón
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers - administration & dosage Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Bile Biological and medical sciences Cells, Cultured Disease Progression Drug Delivery Systems Gastroenterology. Liver. Pancreas. Abdomen Gene expression Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - pathology Liver Liver Cirrhosis - drug therapy Liver Cirrhosis - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Losartan - administration & dosage Losartan - pharmacology Male Medical sciences Other diseases. Semiology Rats Rats, Wistar Rodents Time Factors
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