Glycemic Load, Carbohydrate Intake, and Risk of Colorectal Cancer in Women: A Prospective Cohort Study
Mounting evidence suggests that high circulating levels of insulin might be associated with increased colorectal cancer risk. The glycemic effects of diets high in refined starch may increase colorectal cancer risk by affecting insulin and/or insulin-like growth factor-I levels. We examined the asso...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 2003-06, Vol.95 (12), p.914-916 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | Terry, Paul D. Jain, Meera Miller, Anthony B. Howe, Geoffrey R. Rohan, Thomas E. |
| description | Mounting evidence suggests that high circulating levels of insulin might be associated with increased colorectal cancer risk. The glycemic effects of diets high in refined starch may increase colorectal cancer risk by affecting insulin and/or insulin-like growth factor-I levels. We examined the association between dietary intake and colorectal cancer risk in a cohort of 49 124 women participating in a randomized, controlled trial of screening for breast cancer in Canada. Linkages to Canadian mortality and cancer databases yielded data on mortality and cancer incidence up to December 31, 2000. During an average 16.5 years of follow-up, we observed 616 incident cases of colorectal cancer (436 colon cancers, 180 rectal cancers). Rate ratios for colorectal cancer for the highest versus the lowest quintile level were 1.05 (95% confidence interval [CI] = 0.73 to 1.53; Ptrend = .94) for glycemic load, 1.01 (95% CI = 0.68 to 1.51; Ptrend = .66) for total carbohydrates, and 1.03 (95% CI = 0.73 to 1.44; Ptrend = .71) for total sugar. Our data do not support the hypothesis that diets high in glycemic load, carbohydrates, or sugar increase colorectal cancer risk. |
| doi_str_mv | 10.1093/jnci/95.12.914 |
| format | Article |
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The glycemic effects of diets high in refined starch may increase colorectal cancer risk by affecting insulin and/or insulin-like growth factor-I levels. We examined the association between dietary intake and colorectal cancer risk in a cohort of 49 124 women participating in a randomized, controlled trial of screening for breast cancer in Canada. Linkages to Canadian mortality and cancer databases yielded data on mortality and cancer incidence up to December 31, 2000. During an average 16.5 years of follow-up, we observed 616 incident cases of colorectal cancer (436 colon cancers, 180 rectal cancers). Rate ratios for colorectal cancer for the highest versus the lowest quintile level were 1.05 (95% confidence interval [CI] = 0.73 to 1.53; Ptrend = .94) for glycemic load, 1.01 (95% CI = 0.68 to 1.51; Ptrend = .66) for total carbohydrates, and 1.03 (95% CI = 0.73 to 1.44; Ptrend = .71) for total sugar. Our data do not support the hypothesis that diets high in glycemic load, carbohydrates, or sugar increase colorectal cancer risk.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/95.12.914</identifier><identifier>PMID: 12813175</identifier><identifier>CODEN: JNCIEQ</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Biological and medical sciences ; Breast Neoplasms - prevention & control ; Canada ; Colorectal cancer ; Colorectal Neoplasms - etiology ; Diet ; Dietary Carbohydrates - administration & dosage ; Feeding Behavior ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Health risk assessment ; Humans ; Hyperglycemia - complications ; Hyperglycemia - etiology ; Mass Screening ; Medical sciences ; Middle Aged ; Odds Ratio ; Prospective Studies ; Randomized Controlled Trials as Topic ; Risk Assessment ; Risk Factors ; Stomach. Duodenum. 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The glycemic effects of diets high in refined starch may increase colorectal cancer risk by affecting insulin and/or insulin-like growth factor-I levels. We examined the association between dietary intake and colorectal cancer risk in a cohort of 49 124 women participating in a randomized, controlled trial of screening for breast cancer in Canada. Linkages to Canadian mortality and cancer databases yielded data on mortality and cancer incidence up to December 31, 2000. During an average 16.5 years of follow-up, we observed 616 incident cases of colorectal cancer (436 colon cancers, 180 rectal cancers). Rate ratios for colorectal cancer for the highest versus the lowest quintile level were 1.05 (95% confidence interval [CI] = 0.73 to 1.53; Ptrend = .94) for glycemic load, 1.01 (95% CI = 0.68 to 1.51; Ptrend = .66) for total carbohydrates, and 1.03 (95% CI = 0.73 to 1.44; Ptrend = .71) for total sugar. Our data do not support the hypothesis that diets high in glycemic load, carbohydrates, or sugar increase colorectal cancer risk.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - prevention & control</subject><subject>Canada</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - etiology</subject><subject>Diet</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hyperglycemia - complications</subject><subject>Hyperglycemia - etiology</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Prospective Studies</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Biological and medical sciences Breast Neoplasms - prevention & control Canada Colorectal cancer Colorectal Neoplasms - etiology Diet Dietary Carbohydrates - administration & dosage Feeding Behavior Female Gastroenterology. Liver. Pancreas. Abdomen Health risk assessment Humans Hyperglycemia - complications Hyperglycemia - etiology Mass Screening Medical sciences Middle Aged Odds Ratio Prospective Studies Randomized Controlled Trials as Topic Risk Assessment Risk Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Studies Tumors Women |
| title | Glycemic Load, Carbohydrate Intake, and Risk of Colorectal Cancer in Women: A Prospective Cohort Study |
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