Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells

Abnormal proteolytic processing of amyloid precursor protein (APP) is thought to be central to the formation and deposition of beta amyloid peptide in Alzheimer's disease. A putative "secretase" activity normally releases an amino-terminal APP fragment by cleaving APP at residues with...

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Veröffentlicht in:	The Journal of biological chemistry 1992-12, Vol.267 (35), p.25602-25608
Hauptverfasser:	SAHASRABUDHE, S. R, SPRUYT, M. A, MUENKEL, H. A, BLUME, A. J, VITEK, M. P, JACOBSEN, J. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - isolation & purification Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases Animals Aspartic Acid Endopeptidases Biological and medical sciences Cell Line Cell Membrane - metabolism CHO Cells Cloning, Molecular Cricetinae Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Endopeptidases - metabolism Enkephalin, Methionine - genetics Epitopes - analysis Humans Kinetics Medical sciences Molecular Sequence Data Molecular Weight Mutation Neurology Oligopeptides - immunology Peptide Mapping Plasmids Protein Processing, Post-Translational Restriction Mapping Substance P - genetics Transfection Tumor Cells, Cultured
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